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what is 'anti-ro (ss-a) antibodies'? Definition for Anti-Ro (SS-A) antibodies antibodies against certain collagen vascular diseases Anti-Ro (SS-A) antibodies is also known as: Anti Ro/SS A antibodies, Anti Ro/SSA Antibody, Anti-Ro (SS-A) antibody, Anti-SS-A, Anti-SSA (Ro) antibody, SS-A, Sjogren Syndrome A antibodies, anti-Ro antibody, anti-Ro titers Anti-Ro (SS-A) antibodies is a medical procedure used for such diagnoses as: Sjogren's Syndrome, arthritis and rheumatoid arthritis. related diagnosis for 'anti-ro (ss-a) antibodies' 1 - 5 of 6 diagnosis Sjogren's Syndrome multisystem auto immune disease that also affects tear and salivary glands Anti-Ro (SS-A) antibodies and Sjogren's Syndrome arthritis chronic autoimmune disorder affecting joints and other body tissues Anti-Ro (SS-A) antibodies and arthritis rheumatoid arthritis chronic autoimmune disorder affecting joints and other body tissues Anti-Ro (SS-A) antibodies and rheumatoid arthritis polymyositis inflammation of muscles Anti-Ro (SS-A) antibodies and polymyositis systemic lupus erythematosis multisystem connective tissue autoimmune disease Anti-Ro (SS-A) antibodies and systemic lupus erythematosis dermatomyositis connective tissue disorder involving muscles and skin Anti-Ro (SS-A) antibodies and dermatomyositis for more please login, login is free (click to login) related procedure for 'anti-ro (ss-a) antibodies'/associated diagnoses 1 - 5 of 131 procedures Anti-single stranded DNA antibodies (anti-ssDNA) Anti-Ro (SS-A) antibodies and Anti-single stranded DNA antibodies (anti-ssDNA) Complete Blood Count Anti-Ro (SS-A) antibodies and Complete Blood Count Erythrocyte Sedimentation Rate (ESR) Anti-Ro (SS-A) antibodies and Erythrocyte Sedimentation Rate (ESR) Rheumatoid Factor (RF) Anti-Ro (SS-A) antibodies and Rheumatoid Factor (RF) Antihistone antibodies Anti-Ro (SS-A) antibodies and Antihistone antibodies CT scan Anti-Ro (SS-A) antibodies and CT scan Comprehensive eye exam Anti-Ro (SS-A) antibodies and Comprehensive eye exam Schirmer test Anti-Ro (SS-A) antibodies and Schirmer test Slit lamp examination Anti-Ro (SS-A) antibodies and Slit lamp examination Antinuclear Antibody (ANA) Antinuclear antibody blood test used to screen for autoimmune disorders Anti-Ro (SS-A) antibodies and Antinuclear Antibody (ANA) Blood, Platelet Count Platelet Count Anti-Ro (SS-A) antibodies and Blood, Platelet Count Intravenous infusion of immunoglobulin (IVIG) Anti-Ro (SS-A) antibodies and Intravenous infusion of immunoglobulin (IVIG) Liver Function Tests elevated liver enzymes Anti-Ro (SS-A) antibodies and Liver Function Tests indirect immunofluorescence (IIF) Anti-Ro (SS-A) antibodies and indirect immunofluorescence (IIF) Single-Stranded (ss)-DNA Antibody Anti-Ro (SS-A) antibodies and Single-Stranded (ss)-DNA Antibody Chest X-ray Radiological technique to image the chest Anti-Ro (SS-A) antibodies and Chest X-ray Nailfold capillary microscopy Anti-Ro (SS-A) antibodies and Nailfold capillary microscopy Physical and Occupational Therapy Arthritis Physical and Occupational Therapy Anti-Ro (SS-A) antibodies and Physical and Occupational Therapy C Reactive Protein (CRP) Anti-Ro (SS-A) antibodies and C Reactive Protein (CRP) C1q binding assay Anti-Ro (SS-A) antibodies and C1q binding assay for more please login, login is free (click to login) related medication for 'anti-ro (ss-a) antibodies'/associated diagnoses 1 - 5 of 131 drugs hydroxychloroquine Anti-Ro (SS-A) antibodies and hydroxychloroquine naproxen(naprelan '500') Anti-Ro (SS-A) antibodies and naproxen(naprelan '500') methotrexate Anti-Ro (SS-A) antibodies and methotrexate azathioprine(imuran) Anti-Ro (SS-A) antibodies and azathioprine(imuran) hydroxychloroquine(plaquenil sulfate) Anti-Ro (SS-A) antibodies and hydroxychloroquine(plaquenil sulfate) ibuprofen(motrin) Anti-Ro (SS-A) antibodies and ibuprofen(motrin) methotrexate(trexall) Anti-Ro (SS-A) antibodies and methotrexate(trexall) prednisone(deltasone) Anti-Ro (SS-A) antibodies and prednisone(deltasone) diclofenac(voltaren) Anti-Ro (SS-A) antibodies and diclofenac(voltaren) indomethacin(indocin) Anti-Ro (SS-A) antibodies and indomethacin(indocin) abatacept Anti-Ro (SS-A) antibodies and abatacept abatacept(orencia ) Anti-Ro (SS-A) antibodies and abatacept(orencia ) adalimumab Anti-Ro (SS-A) antibodies and adalimumab anakinra(kineret ) Anti-Ro (SS-A) antibodies and anakinra(kineret ) aspirin Anti-Ro (SS-A) antibodies and aspirin aspirin(easprin) Anti-Ro (SS-A) antibodies and aspirin(easprin) auranofin Anti-Ro (SS-A) antibodies and auranofin auranofin(ridaura ) Anti-Ro (SS-A) antibodies and auranofin(ridaura ) betamethasone Anti-Ro (SS-A) antibodies and betamethasone capsaicin topical(capsaicin ) Anti-Ro (SS-A) antibodies and capsaicin topical(capsaicin ) for more please login, login is free (click to login) The following are types of physicians relevant for 'Anti-Ro (SS-A) antibodies'. related types of physicians 'family practitioner, internist, rheumatologist' show local physicians postal code Find Local stars represent relevance to topic not rating more The results are computer generated suggestions to help you find a physician. MEDgle does not recommend any particular type of physician or claim to be complete or accurate in the providers and specialties suggested. web search results for 'anti-ro (ss-a) antibodies'? Results 1 - 50 - Anti-Ro (SS-A) antibodies Anti-Ro/SSA and anti-La/SSB autoantibodies in the tear fluid of ... Isotype distribution of anti-Ro/SS-A and anti-La/SS-B antibodies in plasma and ... syndrome: association of anti-Ro(SS-A) antibodies with vasculitis, hematologic ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1772044   www.pubmedcentral.nih.gov - summary Ro and La vs. SS-A and SS-B antibodies - Health and Medical Information ... Ro antibody is also referred to as SS-A or anti-Ro antibody. ... Top 3. Ro and La vs. SS-A and SS-B antibodies Related Articles. Antinuclear Antibody ... http://www.medicinenet.com/script/main/art.asp?articlekey=10140   www.medicinenet.com - summary Anti-Ro/SSA and La/SSB antibodies. [Autoimmunity. 2005] - PubMed Result Detection of anti-Ro(SSA) antibodies in autoimmune diseases: comparison of five methods. ... The detection of anti-Ro/SS-A and anti-La/SS-B antibodies. ... http://www.ncbi.nlm.nih.gov/pubmed/15804706   www.ncbi.nlm.nih.gov - summary MRL/lpr mice produce anti-Ro 52,000 MW antibodies: detection, analysis ... ... lpr mice produce the anti-Ro/SS-A and anti-La/SS-B autoantibodies common to ... Antibodies to Ro 60,000 MW and La were found in a low percentage of the older ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1415008   www.pubmedcentral.nih.gov - summary Autoantibodies in human anti-Ro sera specifically recognize ... ... the existence of a novel autoantibody specificity linked to anti-Ro antibodies. ... A 52-kD protein is a novel component of the SS-A/Ro antigenic particle. ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1534155   www.pubmedcentral.nih.gov - summary eMedicine - Sjogren Syndrome : Article Excerpt by Robert A Schwartz Sjogren syndrome (SS) is a chronic systemic disorder characterized by ... Anti-Ro/SS-A and anti-La/SS-B antibodies are strongly associated with HLA-DR2 and HLA-DR3. ... http://www.emedicine.com/derm/byname/Sjogren-Syndrome.htm   www.emedicine.com - summary Anti-nuclear antibody - Wikipedia, the free encyclopedia Anti-nuclear antibodies (ANAs, also known as anti-nuclear factor or ... Anti-dsDNA (double-stranded DNA) Anti-Ro (SS-A) Anti-La (SS-B) Anti-Sm (Smith antigen) ... http://en.wikipedia.org/wiki/Anti-nuclear_antibody   en.wikipedia.org - summary Circulating auto-antibodies against nuclear and no...[Clin Rheumatol ... PubMed is a service of the U.S. National Library of Medicine that includes over ... presence of anti-Ro/SS-A and anti-La/SS-B antibodies reached statistical ... http://www.ncbi.nlm.nih.gov/pubmed/16249826   www.ncbi.nlm.nih.gov - summary Serologic characteristics in primary biliary cirrh...[Scand J ... Anti-52-kD Ro antibodies seem to be a characteristic serologic finding for SS in ... syndrome: association of anti-Ro(SS-A) antibodies with vasculitis, hematologic ... http://www.ncbi.nlm.nih.gov/pubmed/7939404   www.ncbi.nlm.nih.gov - summary Antibodi anti-nuklear - Wikipedia Indonesia, ensiklopedia bebas ... Antibodi anti-nuclear (ANA, Anti-nuclear antibodies) atau dikenal juga sebagai ... Anti-dsDNA (DNA rantai ganda) Anti-Ro (SS-A) Anti-La (SS-B) Anti-Sm (Antigen Smith) ... http://id.wikipedia.org/wiki/Antibodi_anti-nuklear   id.wikipedia.org - summary Genetic deficiency of C4, C2 or C1q and lupus syndromes. Association ... Association with anti-Ro (SS-A) antibodies. ... syndrome: association of anti-Ro(SS-A) antibodies with vasculitis, hematologic ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1577461   www.pubmedcentral.nih.gov - summary Extractable nuclear antigens - Wikipedia, the free encyclopedia i.e. SS-A = Ro and SS-B = La. [edit] ENA 4. ENA 4 is a grouping of antibodies often used to ... anti-RNP (for MCTD) anti-La (for Sjögren's) anti-Ro (for ... http://en.wikipedia.org/wiki/Extractable_nuclear_antigen   en.wikipedia.org - summary eMedicine - Keratoconjunctivitis, Sicca : Article Excerpt by Fernando H ... This condition is characterized by inadequate tear film protection of the cornea because of either inadequate tear ... anti-Ro [SS-A] and anti-La [SS-B] ... http://www.emedicine.com/oph/byname/Keratoconjunctivitis--Sicca.htm   www.emedicine.com - summary Association of neutropenia in systemic lupus erythematosus (SLE) with ... Three patients with a Ro precipitin had anti-HLA antibodies, two of whom had a ... syndrome: association of anti-Ro (SS-A) antibodies with vasculitis, hematologic ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1905619   www.pubmedcentral.nih.gov - summary Frequency of anti-nuclear antibodies in multiple s...[Neurology. 1995 ... PubMed is a service of the U.S. National Library of Medicine that ... Frequency and significance of anti-Ro (SS-A) antibodies in multiple sclerosis patients. ... http://www.ncbi.nlm.nih.gov/pubmed/7854544   www.ncbi.nlm.nih.gov - summary Defining a novel 75-kDa phosphoprotein associated with SS-A/Ro and ... ... pp75, including 1 mother in whom anti?SS-A/Ro antibodies were not detected. ... The presence of anti?SS-A/Ro antibodies in the sera of mothers whose children ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pub...   www.pubmedcentral.nih.gov - summary eMedicine - Lupus Erythematosus, Subacute Cutaneous : Article by ... Anti-native DNA (double-stranded or nDNA) antibodies usually reflect SLE, but ... Cutaneous diseases in adults associated with anti-Ro/SS-A autoantibody production. ... http://emedicine.com/DERM/topic248.htm   emedicine.com - summary Future Directions of Lupus Research ... autoantibody systems (Sm and Ro), antibodies to a structure on ... Anti-Ro, anti-La and antinuclear antibodies occurred very early before diagnosis, ... http://www.niams.nih.gov/about_us/mission_and_purpose/lupus_plan.asp   www.niams.nih.gov - summary eMedicine - Keratoconjunctivitis, Sicca : Article Excerpt by: Fernando ... Keratoconjunctivitis, Sicca - This condition is characterized by inadequate tear film protection of the cornea because ... anti-Ro [SS-A] and anti-La [SS-B] ... http://www.emedicine.com/oph/byname/keratoconjunctivitis-sicca.htm   www.emedicine.com - summary Enhanced membrane expression of the 52 kDa Ro(SS-A) and La(SS-B ... Anti-Ro (SS-A) antibodies from Ro (SS-A)-immunized mice. Arthritis Rheum. ... a reflection of vasculitis and association with anti-Ro(SSA) antibodies. ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=7492240   www.pubmedcentral.nih.gov - summary Calreticulin - Wikipedia, the free encyclopedia ... sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies. ... referred to calreticulin as an Ro/SS-A antigen, but this was later ... http://en.wikipedia.org/wiki/Calreticulin   en.wikipedia.org - summary Ro/SSA and La/SSB specific IgA autoantibodies in serum of patients with ... Ro/SS-A and the pathogenic significance of its antibodies. J Autoimmun. 1989 Aug;2(4):375?381. ... The detection of anti-Ro/SS-A and anti-La/SS-B antibodies. ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1752767   www.pubmedcentral.nih.gov - summary Distribution and antigen specificity of anti-U1RNP antibodies in ... Antibodies against U1RNP, Ro/SS-A, La/SS-B, and Sm antigens were detected using ... Anti-Ro/SS-A were detected in four (22%) of the 18 patients with SSc positive ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1905346   www.pubmedcentral.nih.gov - summary eMedicine - Neonatal Lupus and Cutaneous Lupus Erythematosus in ... ... (NLE) is related to the anti-Ro (SS-A) antibody in more than 90% of patients. Occasionally, patients only have anti-La (SS-B) or anti-U1RNP antibodies. ... http://www.emedicine.com/ped/topic602.htm   www.emedicine.com - summary Proteinase 3 and dihydrolipoamide dehydrogenase (E3) are major ... ... 15·6%, anti-dsDNA in 8·5%, aCL in 5%, anti-SS-B/La in 4·1%, anti-SS-A/Ro (60 kD) ... HCV patients with anti-E3 antibodies showed a higher prevalence of liver ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1906401   www.pubmedcentral.nih.gov - summary Systemic Lupus Erythematosus (SLE) Causes, Symptoms, Treatment, Signs ... Get information on lupus (SLE) disease treatment, signs, diagnosis, types of symptoms (butterfly, discoid rash), causes ... as anti-Ro (or SS-A) and anti-La ... http://www.medicinenet.com/systemic_lupus/page5.htm   www.medicinenet.com - summary Cellular mechanism of the conduction abnormalities induced by serum ... The detection of anti-Ro/SS-A and anti-La/SS-B antibodies. ... Provost TT, Guarnieri T. Anti-Ro/SS-A antibodies in the pathophysiology of ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=293909   www.pubmedcentral.nih.gov - summary Molecular cloning, expression, and chromosome 19 localization of a ... Association with anti-Ro (SS-A) antibodies. Clin Exp Immunol. 1985 Dec;62(3):678?684. ... Ro/SS-A and the pathogenic significance of its antibodies. J ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=296583   www.pubmedcentral.nih.gov - summary Biochemical and immunological heterogeneity of the Ro ribonucleoprotein ... Anti-SS-A antibody and other antinuclear antibodies in systemic lupus ... reactivity among SLE patients with or without anti-Ro (SS-A) antibodies. J Rheumatol. ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=303979   www.pubmedcentral.nih.gov - summary Implications of anti-Ro/Sjögren's syndrome A antigen autoantibody in ... ... and anti-Sjogren's syndrome antigen A (SS-A/Ro) antibodies in female blood donors. ... detection of isotypes of anti-SS-B antibodies by ELISA and Farr ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=424215   www.pubmedcentral.nih.gov - summary eMedicine - Sjogren Syndrome : Article by Eyal Muscal, MD Anti-Ro (SS-A) is found in 40-45% of adult patients with Sjögren syndrome, and ... Cryoglobulins and, occasionally, antiphospholipid antibodies ... http://www.emedicine.com/ped/topic2811.htm   www.emedicine.com - summary Antibody tests for lupus - Yahoo! Health Anti-SS-A (also called Ro). Anti-SS-B (also called La). Anti-dsDNA ... Anti-SS-A (Ro) and anti-SS-B (La) antibodies are not specific for lupus and are ... http://health.yahoo.com/lupus-resources/antibody-tests-for-l...   health.yahoo.com - summary Sjogren's syndrome: Complications - MayoClinic.com Sjogren's syndrome ? Comprehensive overview covers symptoms, causes, ... antibodies, anti-Ro (also called anti-SS-A) and anti-La (also called anti-SS-B) ... http://www.mayoclinic.com/health/sjogrens-syndrome/DS00147/D...   www.mayoclinic.com - summary Autoantibodies to the RoRNP particles. Autoantibodies to the Ro/SS-A particle react ... M. Homozygous C2 deficiency, lupus erythematosus, and anti-Ro (SSA) antibodies. Arthritis Rheum. ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1534139   www.pubmedcentral.nih.gov - summary Anti-p57: a novel association with neonatal lupus. ... TA Jr. Anti-SS-A antibodies and fetal outcome in maternal systemic lupus erythematosus. ... Anti-Ro (SS-A) and anti-La (SS-B) in patients with Sjögren's ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1534148   www.pubmedcentral.nih.gov - summary Antibodies to nRNP, Sm, Ro(SSA) and La(SSB) detected by ELISA: their ... ... syndrome: association of anti-Ro(SS-A) antibodies with vasculitis, hematologic ... detection of isotypes of anti-SS-B antibodies by ELISA and Farr assays ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1577428   www.pubmedcentral.nih.gov - summary Molecular analysis of the RNA and protein components recognized by anti ... ... to anti-La(SS-B) reactivity, all 34 sera were shown to contain anti-Ro(SS-A) ... Predictive value of SS-B precipitating antibodies in Sjoögren's syndrome. ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1577484   www.pubmedcentral.nih.gov - summary HLA-DQ gene complementation and other histocompatibility relationships ... ... to rheumatoid factor and antibodies to Ro (SS-A) and with hypocomplementemia. ... Anti-Ro (SS-A) and anti-La (SS-B) in patients with Sjögren's syndrome. ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=296767   www.pubmedcentral.nih.gov - summary eMedicine - Lupus Erythematosus, Bullous : Article by Hillary D Johnson Anti-dsDNA, anti-Sm, anti-Ro/SS-A, anti-La/SS-B, and ... included a speckled pattern of ANAs, anti-Ro/SS-A and/or La/SS-B antibodies, and a positive ... http://www.emedicine.com/derm/topic246.htm   www.emedicine.com - summary Heterogeneity of the Ro/SSA antigen. Different molecular forms in ... Anti-Ro (SS-A) and anti-La (SS-B) in patients with Sjögren's syndrome. ... Anti-SS-A antibody and other antinuclear antibodies in systemic lupus erythematosus. ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=303820   www.pubmedcentral.nih.gov - summary Protein heterogeneity in the human Ro/SSA ribonucleoproteins. The 52 ... Anti-Ro (SS-A) and anti-La (SS-B) in patients with Sjögren's ... Human monoclonal anti-La antibodies. The La protein resides on a subset of Ro particles. ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=1985094   www.pubmedcentral.nih.gov - summary eMedicine - Granulomatous Diseases of the Head and Neck : Article by ... Lupus is a disease that is caused by the deposition of antibodies and immune ... A nonspecific test, such as the ANA test, the SS-A (anti-Ro) test, or the SS-B ... http://www.emedicine.com/ent/topic768.htm   www.emedicine.com - summary Sjogren's Syndrome - 10 Things You Should Know About Sjogren's Syndrome Sjogren's syndrome is an annoying but treatable condition. ... antibodies are known as: anti-SS-A and anti-SS-B (also referred to as anti-Ro ... http://arthritis.about.com/od/sjogrens/a/sjogrens_facts.htm   arthritis.about.com - summary New Coupled-Particle Light-Scattering Assay for Detection of Ro/SSA (52 ... Their presence also has a prognostic value: anti-Ro/SSA autoantibodies are more ... two anti-Ro antibodies in patients with an established diagnosis of SS or SLE. ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?&artid=96172   www.pubmedcentral.nih.gov - summary Antibodies to extractable nuclear antigens. Has technological drift ... The detection of anti-Ro/SS-A and anti-La/SS-B antibodies. ... Dissociation of immune responses to the SS-A (Ro) 52-kd and 60-kd polypeptides ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1731369   www.pubmedcentral.nih.gov - summary The mapping of the human 52-kD Ro/SSA autoantigen ...[Am J Hum Genet ... 52-kD SS-A/Ro: genomic structure and identification of an alternatively spliced ... of the Ro52 gene associated with anti-Ro 52-kd autoantibodies in patients with ... http://www.ncbi.nlm.nih.gov/pubmed/8094596   www.ncbi.nlm.nih.gov - summary The 52 000 MW Ro/SS-A autoantigen in Sjögren's syndrome/systemic lupus ... The 52 000 MW Ro/SS-A (Ro52) protein is a major target of autoantibodies in ... the existence of a separate population of anti-RNF15 antibodies in patient sera. ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1782712   www.pubmedcentral.nih.gov - summary Clinical and serological associations with anti-RNA polymerase ... Furthermore, using a sensitive ELISA method, anti-Ro antibodies have been ... of 52-kDa and 60-kDa Ro/SS-A autoantibodies in Japanese patients with systemic ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1905338   www.pubmedcentral.nih.gov - summary SS-56, a novel cellular target of autoantibody responses in Sjögren ... ... SLE patients with detectable anti?SS-56 antibodies had a visceral manifestation. ... Sibilia J. Ro(SS-A) and anti-Ro(SS-A): an update. Rev Rhum Engl Ed. ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=200937   www.pubmedcentral.nih.gov - summary Lupus/Sjögren's autoantibody specificities in sera with paraproteins. Anti-Ro (SS-A) and anti-La (SS-B) in patients with Sjögren's syndrome. Arthritis Rheum. ... analysis of monoclonal anti-DNA antibodies from B6-lpr/lpr ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=442211   www.pubmedcentral.nih.gov - summary show more 1  2

Chat with eNurse Kim about 'Anti-Ro (SS-A) antibodies' or something else! quick facts related diagnosis category musculoskeletal and connective tissue disorders