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what is 'topoisomerase inhibitors'? Definition for topoisomerase inhibitors topoisomerase inhibitors is medication used for such diagnoses as: carcinoma rectum, metastases and ovarian cancer. diagnoses treated with 'topoisomerase inhibitors' 1 - 5 of 8 diagnosis carcinoma rectum large bowel cancer web search for: topoisomerase inhibitors and carcinoma rectum metastases spread of malignant tumors to other body sites web search for: topoisomerase inhibitors and metastases ovarian cancer cancer of ovaries web search for: topoisomerase inhibitors and ovarian cancer breast cancer in females cancer of the breast in females web search for: topoisomerase inhibitors and breast cancer in females bronchogenic carcinoma lung cancer web search for: topoisomerase inhibitors and bronchogenic carcinoma colon cancer large bowel cancer web search for: topoisomerase inhibitors and colon cancer malignancy cancer web search for: topoisomerase inhibitors and malignancy breast cancer in males cancer of the breast in males web search for: topoisomerase inhibitors and breast cancer in males for more please login, login is free (click to login) related procedures when taking 'topoisomerase inhibitors' 1 - 5 of 253 procedures Biopsy web search for: topoisomerase inhibitors and Biopsy Lymph node biopsy web search for: topoisomerase inhibitors and Lymph node biopsy Chemotherapy Use of chemical substances to treat disease web search for: topoisomerase inhibitors and Chemotherapy Radiation Therapy Use of ionizing radiation or xrays for medical imaging or to treat cancer web search for: topoisomerase inhibitors and Radiation Therapy Tumor markers web search for: topoisomerase inhibitors and Tumor markers cancer vaccines web search for: topoisomerase inhibitors and cancer vaccines Abdominal CAT Scan web search for: topoisomerase inhibitors and Abdominal CAT Scan Complete Blood Count web search for: topoisomerase inhibitors and Complete Blood Count Cytodiagnosis web search for: topoisomerase inhibitors and Cytodiagnosis Immunotherapy web search for: topoisomerase inhibitors and Immunotherapy External Beam Radiation web search for: topoisomerase inhibitors and External Beam Radiation Brachytherapy Sealed source radiotherapy web search for: topoisomerase inhibitors and Brachytherapy CT Pelvis web search for: topoisomerase inhibitors and CT Pelvis Colonoscopy Colonoscopy web search for: topoisomerase inhibitors and Colonoscopy Magnetic Resonance Imaging (MRI) Pelvis web search for: topoisomerase inhibitors and Magnetic Resonance Imaging (MRI) Pelvis Targeted therapies web search for: topoisomerase inhibitors and Targeted therapies CT scan web search for: topoisomerase inhibitors and CT scan Carcinoembryonic Antigen (CEA) web search for: topoisomerase inhibitors and Carcinoembryonic Antigen (CEA) Chest X-ray Radiological technique to image the chest web search for: topoisomerase inhibitors and Chest X-ray CT Guided Needle Biopsy web search for: topoisomerase inhibitors and CT Guided Needle Biopsy for more please login, login is free (click to login) related medication for 'topoisomerase inhibitors' 1 - 5 of 96 drugs paclitaxel web search for: topoisomerase inhibitors and paclitaxel bevacizumab web search for: topoisomerase inhibitors and bevacizumab docetaxel web search for: topoisomerase inhibitors and docetaxel bleomycin web search for: topoisomerase inhibitors and bleomycin cetuximab web search for: topoisomerase inhibitors and cetuximab ifosfamide web search for: topoisomerase inhibitors and ifosfamide panitumumab web search for: topoisomerase inhibitors and panitumumab vinblastine web search for: topoisomerase inhibitors and vinblastine cyclophosphamide web search for: topoisomerase inhibitors and cyclophosphamide doxorubicin web search for: topoisomerase inhibitors and doxorubicin gemcitabine web search for: topoisomerase inhibitors and gemcitabine anastrozole web search for: topoisomerase inhibitors and anastrozole epirubicin web search for: topoisomerase inhibitors and epirubicin exemestane web search for: topoisomerase inhibitors and exemestane letrozole web search for: topoisomerase inhibitors and letrozole methotrexate web search for: topoisomerase inhibitors and methotrexate tamoxifen web search for: topoisomerase inhibitors and tamoxifen trastuzumab web search for: topoisomerase inhibitors and trastuzumab capecitabine(xeloda ) web search for: topoisomerase inhibitors and capecitabine(xeloda ) fluorouracil(adrucil ) web search for: topoisomerase inhibitors and fluorouracil(adrucil ) for more please login, login is free (click to login) The following are types of physicians relevant for 'topoisomerase inhibitors'. related types of physicians 'family practitioner, internist, oncologist' show local physicians postal code Find Local stars represent relevance to topic not rating more The results are computer generated suggestions to help you find a physician. MEDgle does not recommend any particular type of physician or claim to be complete or accurate in the providers and specialties suggested. web search results for 'topoisomerase inhibitors'? Results 1 - 50 - topoisomerase inhibitors Topoisomerase inhibitor - Wikipedia, the free encyclopedia Topoisomerase inhibitors are agents designed to interfere with the action of ... Topoisomerase inhibitors are often divided according to which type of enzyme it inhibits. ... http://en.wikipedia.org/wiki/Topoisomerase_inhibitor   en.wikipedia.org - summary Definition of topoisomerase inhibitor - NCI Dictionary of ... topoisomerase inhibitor (TOH-poh-i-SAH-meh-rays in-HIH-bih-ter) ... Certain topoisomerase inhibitors are being studied in the treatment of cancer. ... http://www.nci.nih.gov/Templates/db_alpha.aspx?CdrID=46665   www.nci.nih.gov - summary Resistance to topoisomerase II inhibitors in human glioma ... Resistance to topoisomerase II inhibitors in human glioma cell lines ... For understanding of the resistance to topoisomerase II inhibitors, 50 sublines were isolated as single ... http://www.ncbi.nlm.nih.gov/pubmed/15751272   www.ncbi.nlm.nih.gov - summary Yves Pommier, M. D., Ph. D. Our aims regarding topoisomerase inhibitors are to discover novel inhibitors, and to study the molecular ... Topoisomerase inhibitors are only active on a fraction of patients, ... http://discover.nci.nih.gov/pommier/pommier.htm   discover.nci.nih.gov - summary Inhibition of Human Topoisomerase II in Vitro by Bioactive ... Inhibition of Human Topoisomerase II in Vitro by Bioactive Benzene Metabolites ... Topoisomerase II inhibitors tend to be strong clastogens in mammalian cells (14,20) ... http://ehp.niehs.nih.gov/docs/1996/Suppl-6/frantz.html   ehp.niehs.nih.gov - summary Topoisomerase - Wikipedia, the free encyclopedia Topoisomerase I solves the problem caused by tension generated by winding/unwinding of ... See also topoisomerase inhibitor. Many drugs operate through ... http://en.wikipedia.org/wiki/Topoisomerase   en.wikipedia.org - summary Hybrid Antibacterials. DNA polymerase:topoisomerase inhibitors DNA polymerase:topoisomerase inhibitors. Chengxin Zhi,1 Zheng-yu Long, ... The hybrids inhibited the FQ targets, topoisomerase IV and gyrase, with potencies similar ... http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566945/?+tool=pubmed   www.ncbi.nlm.nih.gov - summary Organism Classes: TOPOISOMERASE INHIBITORS; NATURAL PRODUCTS; ELLIPTICINES; PYRIDOCARBAZOLES; ... Classes: TOPOISOMERASE INHIBITORS; NATURAL PRODUCTS; NUCLEOSIDES, ... http://chemdb.niaid.nih.gov/struct_search/class/class_many.a...   chemdb.niaid.nih.gov - summary Apoptosis Induced by Topoisomerase Inhibitors Abstract: Topoisomerase inhibitors are among the most efficient ... The main pathways leading from topoisomerase-mediated DNA damage to cell death involve ... http://discover.nci.nih.gov/host/2003_apoptosis_abstract.jsp   discover.nci.nih.gov - summary Center for Cancer Research - Staff Pages Top2 inhibitors include the widely used anticancer agents VP-16, ... Our aims regarding topoisomerase inhibitors are to discover novel inhibitors, and to study the molecular ... http://ccr.nci.nih.gov/Staff/Staff.asp?StaffID=742   ccr.nci.nih.gov - summary Methods to assay inhibitors of DNA gyrase and topoisomerase ... Methods to assay inhibitors of DNA gyrase and topoisomerase IV activities. ... DNA gyrase and DNA topoisomerase (topo) IV are the bacterial targets of coumarin and ... http://www.ncbi.nlm.nih.gov/pubmed/18437302   www.ncbi.nlm.nih.gov - summary Yves Pommier, M. D., Ph. D. Topoisomerase I Inhibitors: Molecular and Cellular. Determinants of Activity. Yves Pommier ... 2. 2. Non-camptothecin Top1 poisons: polyheterocyclic aromatic inhibitors ... http://discover.nci.nih.gov/pommier/topo1.htm   discover.nci.nih.gov - summary Topoisomerase I and II inhibitors control caspase-2 pre ... Topoisomerase I and II inhibitors control caspase-2 pre-messenger RNA splicing in human cells. ... Very strikingly, both topoisomerase I (camptothecin and homocamptothecin ... http://www.ncbi.nlm.nih.gov/pubmed/14757846   www.ncbi.nlm.nih.gov - summary Inhibition of human immunodeficiency virus (HIV-1 ... Infection is blocked or substantially reduced by the topoisomerase I inhibitor camptothecin (CPT), but not by two topoisomerase II inhibitors. ... http://gateway.nlm.nih.gov/MeetingAbstracts/ma?f=102196514.html   gateway.nlm.nih.gov - summary Conjugation of human topoisomerase 2 alpha with small ... Conjugation of human topoisomerase 2 alpha with small ubiquitin-like modifiers 2/3 in response to topoisomerase inhibitors: cell cycle stage and ... http://www.ncbi.nlm.nih.gov/pubmed/18381449   www.ncbi.nlm.nih.gov - summary Glycosylated flavones as selective inhibitors of topoisomerase IV. Glycosylated flavones as selective inhibitors of topoisomerase IV. ... These results show that selective inhibitors of topoisomerase IV can be derived from the ... http://www.ncbi.nlm.nih.gov/pmc/articles/PMC163839/   www.ncbi.nlm.nih.gov - summary Nucleic acid inhibitor - Wikipedia, the free encyclopedia DNA inhibitors (such as the quinolones, acting upon DNA gyrase as a topoisomerase inhibitors)[2] ... Antifolates act primarily as inhibitors of both RNA and DNA, and are often ... http://en.wikipedia.org/wiki/Nucleic_acid_inhibitor   en.wikipedia.org - summary Anucleate Cell Blue Assay: a Useful Tool for Identifying ... Anucleate Cell Blue Assay: a Useful Tool for Identifying Novel Type II Topoisomerase Inhibitors ... in the detection of other novel type II topoisomerase inhibitors. ... http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1346804/   www.ncbi.nlm.nih.gov - summary Inhibition of human topoisomerase II in vitro by bioactive ... Inhibition of human topoisomerase II in vitro by bioactive benzene metabolites. ... interfere with topoisomerase II. Since other inhibitors of topoisomerase II have ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1469756   www.pubmedcentral.nih.gov - summary Effect of the DNA topoisomerase II inhibitor VP-16 on ... Effect of the DNA topoisomerase II inhibitor VP-16 on illegitimate recombination in yeast chromosomes. ... of podophyllotoxin, are inhibitors of DNA topoisomerase II and are ... http://www.ncbi.nlm.nih.gov/pubmed/12095698   www.ncbi.nlm.nih.gov - summary Chemotherapy - Wikipedia, the free encyclopedia [edit] Topoisomerase inhibitors (L01CB and L01XX) Topoisomerases are essential enzymes ... Some type I topoisomerase inhibitors include camptothecins: irinotecan and topotecan. ... http://en.wikipedia.org/wiki/Chemotherapy   en.wikipedia.org - summary Maternal exposure to potential inhibitors of DNA ... Maternal exposure to potential inhibitors of DNA topoisomerase II and infant leukemia (United States): a report from the Children's Cancer Group. ... http://www.ncbi.nlm.nih.gov/pubmed/8932918   www.ncbi.nlm.nih.gov - summary NK314, a novel topoisomerase II inhibitor, induces rapid DNA ... It inhibited topoisomerase II activity and stabilized topoisomerase II-DNA cleavable complexes. ... Pretreatment with topoisomerase II catalytic inhibitors, ICRF-193 and ... http://www.ncbi.nlm.nih.gov/pubmed/17998154   www.ncbi.nlm.nih.gov - summary Pharmacological and Therapeutics agents that Target DNA ... DNA topoisomerase inhibitors are commonly used as anticancer drugs (Table VIII) ... main classes of clinical topoisomerase inhibitors target topoisomerases I and II. ... http://discover.nci.nih.gov/pommier/ReplicationInhibitorsText.pdf   discover.nci.nih.gov - summary Inhibitors of DNA topoisomerase II prevent chromatid ... Inhibitors of DNA topoisomerase II prevent chromatid separation in mammalian cells but do not prevent exit ... DNA topoisomerase II (EC 5.99.1.3) is necessary for chromosome ... http://www.ncbi.nlm.nih.gov/pmc/articles/PMC52617/   www.ncbi.nlm.nih.gov - summary Irinotecan - Wikipedia, the free encyclopedia Irinotecan is a topoisomerase 1 inhibitor, which prevents DNA from unwinding. ... The inhibition of topoisomerase I by the active metabolite SN-38 eventually ... http://en.wikipedia.org/wiki/Irinotecan   en.wikipedia.org - summary Differential regulation of NF-?B activation and function by ... Differential regulation of NF-?B activation and function by topoisomerase II inhibitors. Kirsteen J Campbell,1 John M O'Shea,1 and Neil D Perkins1 ... http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459870/?tool=pubmed   www.ncbi.nlm.nih.gov - summary Partial purification of mitochondrial DNA topoisomerase II ... Mitochondrial DNA topoisomerase II from P. falciparum was partially ... The effects of fluoroquinolones, inhibitors of bacterial DNA topoisomerase II or DNA gyrase, against ... http://www.ncbi.nlm.nih.gov/pubmed/12041546   www.ncbi.nlm.nih.gov - summary Microsoft Word - DNA repair modulators.2columns.Website inhibitors currently available to interfere with those pathways. ... Top1cc: Topoisomerase I cleavage complex; Top2: DNA topoisomerase II; Top2cc: ... http://discover.nci.nih.gov/pommier/DNA.repair.modulators.pdf   discover.nci.nih.gov - summary Inhibitors of human immunodeficiency virus integrase. Our results show that although several topoisomerase inhibitors--including doxorubicin, mitoxantrone, ellipticines, and quercetin--are potent ... http://www.ncbi.nlm.nih.gov/pmc/articles/PMC46094/?tool=pubmed   www.ncbi.nlm.nih.gov - summary Topoisomerase inhibitors can selectively interfere with ... Topoisomerase inhibitors can selectively interfere with different stages of simian virus ... Effects of inhibitors of DNA synthesis on spontaneous and ultraviolet ... http://www.ncbi.nlm.nih.gov/pmc/articles/PMC367202/   www.ncbi.nlm.nih.gov - summary Use of a Rapid Throughput In Vivo Screen To Investigate ... Saccharomyces cerevisiae topoisomerase II has been frequently used as a model for testing potential inhibitors of eukaryotic topoisomerase II as antitumor agents. ... http://www.ncbi.nlm.nih.gov/pmc/articles/PMC105561/   www.ncbi.nlm.nih.gov - summary The catalytic DNA topoisomerase II inhibitor dexrazoxane ... The catalytic DNA topoisomerase II inhibitor dexrazoxane (ICRF-187) induces ... This result suggested the lack of a DNA topoisomerase II activity-based cell cycle checkpoint. ... http://www.ncbi.nlm.nih.gov/pubmed/11179439   www.ncbi.nlm.nih.gov - summary Note: Molluscum Contagiosum Virus Topoisomerase: Purification ... Thus, inhibitors of the MCV topoisomerase might be useful as antiviral agents. ... The MCV topoisomerase displays an unusual response to inhibitors for a ... http://www.ncbi.nlm.nih.gov/pmc/articles/PMC109833/   www.ncbi.nlm.nih.gov - summary Metabolic Specificity Profiling of Fluoroquinolones, Non ... Metabolic Specificity Profiling of Fluoroquinolones, Non-Fluorinated Quinolones, and Other DNA Topoisomerase Inhibitors Against Intact Cells of Staphylococcus aureus. ... http://gateway.nlm.nih.gov/MeetingAbstracts/ma?f=102248226.html   gateway.nlm.nih.gov - summary Synthesis and Evaluation of Indenoisoquinoline Topoisomerase ... Synthesis and Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Substituted with Nitrogen Heterocycles. Muthukaman Nagarajan,? Andrew ... http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526314/?tool=pmcentrez   www.ncbi.nlm.nih.gov - summary Topoisomerase II can unlink replicating DNA by precatenane ... Topoisomerase II can unlink replicating DNA by precatenane removal ... Furthermore, RIs generated in the presence of topo II inhibitors have an increased ?Lk, as shown by two ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?&artid=125741   www.pubmedcentral.nih.gov - summary Transcriptional Consequences of Topoisomerase Inhibition Topoisomerase inhibitors have proven to be potent antineoplastic agents. ... Topoisomerase I and II inhibitors modify transcription of the endogenous and episomal c-myc genes. ... http://www.ncbi.nlm.nih.gov/pmc/articles/PMC100007/?tool=pubmed   www.ncbi.nlm.nih.gov - summary Endoplasmic reticulum chaperone protein GRP78 protects cells ... ... challenged with topoisomerase II inhibitors, etoposide and doxorubicin, and topoisomerase I inhibitor, camptothecin. While investigating the mechanism ... http://www.ncbi.nlm.nih.gov/pubmed/12665508   www.ncbi.nlm.nih.gov - summary Definition of camptothecin - NCI Dictionary of Cancer Terms Skip to content. Dictionary of Cancer Terms. Send to Printer. camptothecin. An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors. ... http://www.cancernet.nci.nih.gov/Templates/db_alpha.aspx?print=1&cdrid=45181   www.cancernet.nci.nih.gov - summary Novel camptothecin derivatives as topoisomerase I inhibitors. Novel camptothecin derivatives as topoisomerase I inhibitors. ... entered into the market and are used as topoisomerase I poisons in clinical practice. ... http://www.ncbi.nlm.nih.gov/pubmed/19441934   www.ncbi.nlm.nih.gov - summary Bacterial topoisomerase inhibitors: quinolone and pyridone ... Bacterial topoisomerase inhibitors: quinolone and pyridone antibacterial agents. ... DNA Topoisomerases, Type II, Bacterial/antagonists & inhibitors ... http://www.ncbi.nlm.nih.gov/pubmed/15700957   www.ncbi.nlm.nih.gov - summary Selected DNA Topoisomerase II Inhibitors (3 Candidate ... Primary Uses or Exposures: Etoposide is a DNA topoisomerase II inhibitor used in chemotherapy for non-Hodgkin's lymphoma, small-cell lung cancer, ... http://ntp-server.niehs.nih.gov/index.cfm?objectid=03CA7303-...   ntp-server.niehs.nih.gov - summary Lovastatin protects human endothelial cells from the ... Therefore, lovastatin might be useful clinically for alleviating side-effects of anticancer therapies that include topoisomerase II inhibitors. ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2014634   www.pubmedcentral.nih.gov - summary DNA gyrase and DNA topoisomerase of Bacillus subtilis ... DNA gyrase and DNA topoisomerase of Bacillus subtilis: expression and characterization of ... DNA Topoisomerase IV/metabolism. Enzyme Inhibitors/pharmacology ... http://www.ncbi.nlm.nih.gov/pubmed/12767818   www.ncbi.nlm.nih.gov - summary Topoisomerase II inhibitors, irrespective of their chemical ... Topoisomerase II inhibitors, irrespective of their chemical ... Etoposide and mitoxantrone are immunosuppressive drugs, both acting by inhibiting the topoisomerase II function. ... http://www.ncbi.nlm.nih.gov/pubmed/15494349   www.ncbi.nlm.nih.gov - summary A DNA topoisomerase I inhibitor blocks the differentiation of ... A DNA topoisomerase I inhibitor blocks the differentiation of rat ... Camptothecin, a DNA topoisomerase I blocker, inhibited the increase in progesterone and ... http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1151270/   www.ncbi.nlm.nih.gov - summary Activity of topoisomerase inhibitors against Pneumocystis ... Activity of topoisomerase inhibitors against Pneumocystis carinii in ... Five topoisomerase II inhibitors (amsacrine [m-AMSA], two epipodophyllotoxins, and two ... http://www.ncbi.nlm.nih.gov/pmc/articles/PMC188010/   www.ncbi.nlm.nih.gov - summary Next generation topoisomerase I inhibitors: Rationale and ... Next generation topoisomerase I inhibitors: Rationale and biomarker strategies. ... Several strategies are being explored to develop improved TopoI inhibitors. ... http://www.ncbi.nlm.nih.gov/pubmed/18061144   www.ncbi.nlm.nih.gov - summary The Intra-S-Phase Checkpoint Affects both DNA Replication ... Camptothecin, a specific inhibitor of type I DNA topoisomerase, induces DNA breakage at replication forks. ... Topoisomerase inhibitors can selectively interfere with different ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1952133   www.pubmedcentral.nih.gov - summary show more 1  2

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