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what is 'suramin'? Definition for suramin Suramin is a drug developed by Oskar Dressel and Richard Kothe of Bayer , Germany in 1916, and is still sold by Bayer under the brand name Germanin. According to the National Cancer Institute there are no active clinical trials (as of April 1, 2008). more Suramin is a drug developed by Oskar Dressel and Richard Kothe of Bayer , Germany in 1916, and is still sold by Bayer under the brand name Germanin. According to the National Cancer Institute there are no active clinical trials (as of April 1, 2008). Completed and closed clinical trials are listed here: less diagnoses treated with 'suramin' 1 - 4 of 4 diagnosis African Trypanosomiasis sleeping sickness in Africa web search for: suramin and African Trypanosomiasis adrenocortical carcinoma cancer of adrenal gland web search for: suramin and adrenocortical carcinoma filariasis infectious parasitic tropical disease web search for: suramin and filariasis onchocerciasis parasitic infection of eye causing blindness web search for: suramin and onchocerciasis related procedures when taking 'suramin' 1 - 5 of 28 procedures Complete Blood Count web search for: suramin and Complete Blood Count Cerebrospinal Fluid analysis web search for: suramin and Cerebrospinal Fluid analysis Giemsa staining web search for: suramin and Giemsa staining Ultrasound lymph node web search for: suramin and Ultrasound lymph node serologies for parasites web search for: suramin and serologies for parasites serum immunoglobulins web search for: suramin and serum immunoglobulins tissue specimens ova and or parasites web search for: suramin and tissue specimens ova and or parasites Blood, Platelet Count Platelet Count web search for: suramin and Blood, Platelet Count Bone Marrow Aspiration web search for: suramin and Bone Marrow Aspiration Brain MRI web search for: suramin and Brain MRI CT brain web search for: suramin and CT brain CT scan web search for: suramin and CT scan Cerebrospinal Fluid ELISA web search for: suramin and Cerebrospinal Fluid ELISA Cerebrospinal Fluid PCR web search for: suramin and Cerebrospinal Fluid PCR Cerebrospinal Fluid immunoglobulin M web search for: suramin and Cerebrospinal Fluid immunoglobulin M Cerebrospinal Fluid immunoglobulins web search for: suramin and Cerebrospinal Fluid immunoglobulins Drainage of Lymph Node web search for: suramin and Drainage of Lymph Node Erythrocyte Sedimentation Rate (ESR) web search for: suramin and Erythrocyte Sedimentation Rate (ESR) Lumbar Puncture web search for: suramin and Lumbar Puncture Serum Albumin type of protein in human plasma web search for: suramin and Serum Albumin for more please login, login is free (click to login) related medication for 'suramin' 1 - 5 of 10 drugs effornithine web search for: suramin and effornithine melarsoprol web search for: suramin and melarsoprol pentamidine isethionate web search for: suramin and pentamidine isethionate adriamycin web search for: suramin and adriamycin amocarzine web search for: suramin and amocarzine doxycycline web search for: suramin and doxycycline ivermectin web search for: suramin and ivermectin ketoconazole web search for: suramin and ketoconazole mitotane web search for: suramin and mitotane spironolactone web search for: suramin and spironolactone for more please login, login is free (click to login) The following are types of physicians relevant for 'suramin'. related types of physicians 'family practitioner, infectious disease specialist, internist' show local physicians postal code Find Local stars represent relevance to topic not rating more The results are computer generated suggestions to help you find a physician. MEDgle does not recommend any particular type of physician or claim to be complete or accurate in the providers and specialties suggested. web search results for 'suramin'? Results 1 - 50 - suramin Suramin - Wikipedia, the free encyclopedia Suramin, drug information by JBC Online. Suramin in treating patients with recurrent bladder cancer. National Cancer Institute ... http://en.wikipedia.org/wiki/Suramin   en.wikipedia.org - summary Suramin Sodium Drug Information, Professional Suramin Sodium Drug Information from Drugs.com. Includes Suramin Sodium side effects, ... Suramin may be administered as a preliminary agent prior to ... http://www.drugs.com/MMX/Suramin_Sodium.html   www.drugs.com - summary Suramin Suramin-induced decrease in prostate-specific antigen expression with no effect ... 794-801 BACKGROUND: Suramin, a polysulfonated naphthylurea and a recognized ... http://www.ncbi.nlm.nih.gov/pubmed/8637045?ordinalpos=5&itoo...   www.ncbi.nlm.nih.gov - summary Suramin: Drug Information Provided by Lexi-Comp: Merck Manual Professional Suramin inhibits a number of growth factors and enzymes essential to cell ... Stein CA, "Suramin: A Novel Antineoplastic Agent With Multiple Potential ... http://www.merck.com/mmpe/lexicomp/suramin.html   www.merck.com - summary Suramin - PubChem Public Chemical Database PubChem Compound Summary ... Suramin - Substance Summary (SID 10175) ... Suramin. Polycyclic Compounds. Polycyclic Hydrocarbons, Aromatic. Naphthalenes ... http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=10175   pubchem.ncbi.nlm.nih.gov - summary Definition of suramin - NCI Dictionary of Cancer Terms Report to Nation Finds Declines in Cancer Incidence, Death Rates ... suramin (SOO-rah-min) A drug that is used to treat infections caused by parasites. ... http://www.nci.nih.gov/Templates/db_alpha.aspx?CdrID=45271   www.nci.nih.gov - summary Suramin (Injection Route) - MayoClinic.com Mayo Clinic offers award-winning medical and health information and tools for healthy living. ... Suramin may cause serious side effects. ... http://www.mayoclinic.com/health/drug-information/DR601283   www.mayoclinic.com - summary Colloquium Paper: Suramin inhibits initiation of defense signaling by ... NF 007, a suramin derivative, induced medium alkalinization, indicating that ... Suramin interferes with the binding of several polypeptide signals, including ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pub...   www.pubmedcentral.nih.gov - summary Suramin consumer information from Drugs.com Suramin patient information. ... Suramin may cause serious side effects. ... Pregnancy?Suramin has not been studied in pregnant women. ... http://www.drugs.com/cons/Suramin.html   www.drugs.com - summary Talk:Suramin - Wikipedia, the free encyclopedia This is the talk page for discussing improvements to the Suramin article. ... Retrieved from "http://en.wikipedia.org/wiki/Talk:Suramin" ... http://en.wikipedia.org/wiki/Talk:Suramin   en.wikipedia.org - summary Utilization of triacylglycerol-rich lipoproteins by the working rat ... However, suramin decreased TAG oxidation from both VLDL and CM without affecting ... Suramin non-specifically inhibits all receptors of the LDL-receptor superfamily, ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1664916   www.pubmedcentral.nih.gov - summary Clinical Trials (PDQ®) - National Cancer Institute Suramin and Either Docetaxel or Gemcitabine in Treating Patients With Stage IIIB ... Determine whether suramin plasma concentrations in combination with docetaxel or ... http://www.nci.nih.gov/clinicaltrials/OSU-NCI-5889   www.nci.nih.gov - summary PPADS and suramin as antagonists at cloned P2Y- and P2U-purinoceptors. 1. The effect of suramin and pyridoxalphosphate-6-azophenyl-2',4'-disulphonic ... Suramin was therefore a less potent antagonist at the P2U-purinoceptor than the ... http://www.ncbi.nlm.nih.gov/pubmed/8762097   www.ncbi.nlm.nih.gov - summary The International Pharmacopoeia Fourth Edition - Pharmacopoea ... Suramin sodium should be kept in a tightly closed container, protected from light. ... Suramin sodium contains not less than 96.0% and not more than 100.5% of ... http://www.who.int/phint/en/d/Jb.6.1.401/   www.who.int - summary Kinetics of antagonist actions at rat P2X2/3 heteromeric receptors For suramin (KD1?M) the association rate constant (1?M1s1) was 100 times slower ... Suramin shows less discrimination among the different receptors that have been ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1573256   www.pubmedcentral.nih.gov - summary Pharmacological characterization of the human P2Y11 receptor Suramin was a more potent antagonist than reactive blue 2, whereas pyridoxal ... Each suramin concentration generated a shift in the curves to the right without ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1571754   www.pubmedcentral.nih.gov - summary Pharmacological Therapy for Idiopathic Pulmonary Fibrosis: NHLBI workshop Suramin has the unusual in vitro property of antagonizing the effects of a ... The attractive property of suramin is the relatively promiscuous nature of its ... http://www.nhlbi.nih.gov/meetings/workshops/ipf-sum.htm   www.nhlbi.nih.gov - summary Structural basis for antagonism by suramin of heparin binding to ... Suramin is a competitive inhibitor of heparin binding to many proteins, ... We report the structure of suramin, in complex with the heparin-binding site of ... http://www.ncbi.nlm.nih.gov/pubmed/16086578   www.ncbi.nlm.nih.gov - summary Regional variation in P2 receptor expression in the rat pulmonary ... Also, the P2 receptor antagonist suramin had no effect on the responses to UTP ... Suramin (30?100 ?M) caused a progressive rightward shift of their concentration ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1573537   www.pubmedcentral.nih.gov - summary Influence of suramin on the expression of Fc receptors and other ... Suramin, a polyanionic and polycyclic compound, was initially used for the ... Effects of suramin, an anti-human immunodeficiency virus reverse transcriptase ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1422361   www.pubmedcentral.nih.gov - summary Inhibition of NMDA-gated ion channels by the P2 purinoceptor ... The action of suramin and reactive blue 2 on N-methyl-D-aspartate (NMDA) ... In contrast, 75?M suramin increased the EC50 for NMDA from 13 to 35?M, and ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1565395   www.pubmedcentral.nih.gov - summary Arsenicals (melarsoprol), pentamidine and suramin in the treatment of ... Arsenicals (melarsoprol), pentamidine and suramin in the treatment of human ... Suramin/therapeutic use* Trypanocidal Agents/administration & dosage ... http://www.ncbi.nlm.nih.gov/pubmed/12743807   www.ncbi.nlm.nih.gov - summary Role of P2 purinergic receptors in synaptic transmission under normoxic ... PPADS, suramin, MRS2179 or BBG (brilliant blue G) significantly prevented the ... Suramin, another non-specific P2 receptor antagonist, administered 30 min before ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2096646   www.pubmedcentral.nih.gov - summary Clinical Trials (PDQ®) - National Cancer Institute Phase I/II Study of Low-Dose Suramin and Paclitaxel in Women With Stage IIIB or ... The suramin target dose is defined as the dose at which at least 5 of 6 patients ... http://www.nci.nih.gov/clinicaltrials/OSU-02H0216   www.nci.nih.gov - summary Effects of PPADS and suramin on contractions and cytoplasmic Ca2 ... Effects of suramin on contractions of the guinea-pig vas deferens induced by ... Suramin: a reversible P2-purinoceptor antagonist in the mouse vas deferens. Br ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1909337   www.pubmedcentral.nih.gov - summary Improved muscle healing after contusion injury by the inhibitory effect ... HYPOTHESIS: Suramin enhances muscle healing by both stimulating muscle ... Suramin enhanced myoblast and MDSC differentiation and neutralized MSTN's ... http://www.ncbi.nlm.nih.gov/pubmed/18725651?ordinalpos=1&ito...   www.ncbi.nlm.nih.gov - summary Suramin effects on macrophage phagolysosome formation and antimicrobial ... In addition, suramin-treated macrophages demonstrated enhanced exocytosis of ... However, suramin was found not to inhibit formation of phagolysosomes in ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=421883   www.pubmedcentral.nih.gov - summary The inhibitory effect of suramin on telomerase activity and spheroid ... Suramin at 250 microM and 175 microM reduced telomerase activity and cell ... The increased dose of the suramin-treated group showed changes of spheroid ... http://www.ncbi.nlm.nih.gov/pubmed/18667993   www.ncbi.nlm.nih.gov - summary African Trypanosomiasis in Travelers Returning to the United Kingdom suramin (reconstituted in sterile water to a 10% solution, with ... test dose of 100 to 200 mg of suramin be given before the first ... http://www.cdc.gov/ncidod/eid/vol8no1/pdf/01-0130%20moore.pdf   www.cdc.gov - summary Functional characterization of the P2X4 receptor orthologues All three orthologues were relatively suramin-insensitive (IC50>100?M) and ... Low sensitivity to the antagonist suramin was observed at the mouse, human and ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1571843   www.pubmedcentral.nih.gov - summary Suramin rapidly alters cellular tyrosine phosphorylation in prostate ... Suramin inhibition of growth factor receptor binding and mitogenicity in AKR-2B cells. ... Use of suramin in treatment of prostatic carcinoma refractory to ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=443367   www.pubmedcentral.nih.gov - summary Placental dysfunction in Suramin-treated rats--a new model for pre ... In both rat strains Suramin decreased the placental blood flow and caused fetal ... We conclude, that Suramin injections to pregnant rats cause a state of placental ... http://www.ncbi.nlm.nih.gov/pubmed/15850646?ordinalpos=15&it...   www.ncbi.nlm.nih.gov - summary Selective and competitive antagonism by suramin of ATP-stimulated ... Suramin (300 microM) did not affect the dopamine-secretion stimulated by high K+ ... Suramin antagonized this effect over the same concentration range that ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1917940   www.pubmedcentral.nih.gov - summary Suramin and radiotherapy in newly diagnosed glioblastoma: Phase 2 NABTT ... Suramin is a polysulfonated naphthylurea that was developed in the 1920s as a ... Suramin has received attention recently as a potential antineoplastic agent ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1871972   www.pubmedcentral.nih.gov - summary Early Events in the Signal Pathway for the Oxidative Burst in Soybean ... Suramin, a G-protein inhibitor, inhibited the burst if added up to 90 min after ... Increasing the concentration of suramin did not significantly reduce H2O2 ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=59347   www.pubmedcentral.nih.gov - summary Evidence for the Expression of Multiple Uracil Nucleotide-Stimulated P2 ... In the ear artery, both suramin and PPADS inhibited responses to UTP (Figure ... Suramin antagonizes recombinant P2Y2 receptors at concentrations up to 100?M, ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2189772   www.pubmedcentral.nih.gov - summary Suramin antagonizes responses to P2-purinoceptor agonists and ... 1. Suramin, an inhibitor of several types of ATPase, was investigated for its ... Suramin had no significant effect at 1 or 10 microM. ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1917343   www.pubmedcentral.nih.gov - summary Suramin inhibits death receptor-induced apoptosis in vitro and ... Suramin is a polysulfonated derivative of urea and has been widely used both to ... Here we show that suramin inhibits apoptosis induced through death receptors in ... http://www.ncbi.nlm.nih.gov/pubmed/15146177   www.ncbi.nlm.nih.gov - summary Individual sympathetic varicosities possess different sensitivities to ... Suramin is an antagonist at P2-purinoceptors (Dunn & Blakeley, 1988), blocking ... However suramin tends to potentiate the contractions produced by exogenous ATP ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1571817   www.pubmedcentral.nih.gov - summary Extended pharmacological profiles of rat P2Y2 and rat P2Y4 receptors ... For rP2Y4, the order was RB-2>>suramin>PPADS> TNP-ATP and RB-2 was a competitive ... In contrast, suramin was effective only at high concentrations at rat P2Y4 ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1574132   www.pubmedcentral.nih.gov - summary Placental dysfunction in Suramin-treated rats: impact of maternal ... In the U rats Suramin also caused increased fetal resorption rate, increased ... The maternal and fetal effects of Suramin and diabetes were more pronounced in ... http://www.ncbi.nlm.nih.gov/pubmed/15784502?ordinalpos=16&it...   www.ncbi.nlm.nih.gov - summary UV-B-induced signaling events leading to enhanced-production of ... Suramin inhibited alkalinization of the growth medium for all exposure times of ... We next examined effects of suramin, an inhibitor of G-protein inhibitor, ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2213653   www.pubmedcentral.nih.gov - summary Properties of P2X and P2Y receptors are dependent on artery diameter in ... Suramin (10?100?M) produced substantial parallel rightward shifts of the ... Responses in large vessels were unaffected by suramin. ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1572518   www.pubmedcentral.nih.gov - summary Suramin is an inhibitor of DNA topoisomerase II in vitro and in Chinese ... Suramin inhibition of growth factor receptor binding and mitogenicity in AKR ... Effects of suramin, an anti-human immunodeficiency virus reverse transcriptase ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?&artid=48796   www.pubmedcentral.nih.gov - summary The effect of sildenafil on the altered thoracic aorta smooth muscle ... Suramin injections caused increased blood pressure, protein in urine and caused ... Contraction responses of phenylephrine, increased significantly in suramin group. ... http://www.ncbi.nlm.nih.gov/pubmed/18538317?ordinalpos=2&ito...   www.ncbi.nlm.nih.gov - summary Effects of the P2-purinoceptor antagonist, suramin, on human platelet ... 2. Suramin (100 microM) had no inhibitory effect on ADP-induced platelet ... This lack of effect of suramin on platelets in plasma is probably due to its ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1908649   www.pubmedcentral.nih.gov - summary Sympathetic vasoconstrictor regulation of mouse colonic submucosal ... The P2 receptor antagonist suramin (100 ?m) or the ?1-adrenoceptor antagonist ... In no cases did suramin abolish the constriction to nerve stimulation. ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2277024   www.pubmedcentral.nih.gov - summary In Vitro and In Vivo Activities of Trybizine Hydrochloride against ... T. evansi STIB 780 is highly resistant to quinapyramine and suramin (22) ... Trybizine and suramin had an antagonistic effect on T. brucei subsp. ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=105956   www.pubmedcentral.nih.gov - summary Effects of heptanol on the neurogenic and myogenic contractions of the ... Suramin inhibited powerfully the first phase of contraction and a monophasic ... These suramin-resistant contractions were affected by heptanol in the same way ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1565808   www.pubmedcentral.nih.gov - summary Directed Molecular Screening for RecA ATPase Inhibitors The presence of suramin (100 ?M) in this reaction completely abrogated the ... We further reported that suramin, Congo Red, and bis-ANS strongly inhibit RecA's ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1933586   www.pubmedcentral.nih.gov - summary show more 1  2

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