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silibinin
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what is 'silibinin'?
Definition for silibinin
Silibinin ( INN ), also known as silybin , is the major active constituent of silymarin , the mixture of flavonolignans extracted from blessed milk thistle ( Silybum marianum ). Both in vitro and animal research suggest that silibinin has hepatoprotective (antihepatotoxic) properties that protect liver cells against toxins.
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Silibinin ( INN ), also known as silybin , is the major active constituent of silymarin , the mixture of flavonolignans extracted from blessed milk thistle ( Silybum marianum ). Both in vitro and animal research suggest that silibinin has hepatoprotective (antihepatotoxic) properties that protect liver cells against toxins. [ 1 ] [ 2 ] Silibinin has also demonstrated anti-cancer effects against human prostate adenocarcinoma cells, estrogen-dependent and -independent human breast carcinoma cells, human ectocervical carcinoma cells, human colon cancer cells, and both small and nonsmall human lung carcinoma cells. [ 3 ] [ 4 ] [ 5 ] [ 6 ]
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diagnoses treated with 'silibinin'
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diagnosis
mushroom poisoning
poisoning caused by toxic mushrooms
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silibinin and mushroom poisoning
related procedures when taking 'silibinin'
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procedures
ABO Blood Groups
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silibinin and ABO Blood Groups
Activated charcoal
oral emergency decontaminant in certain poisonings
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silibinin and Activated charcoal
Activated partial thromboplastin time
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silibinin and Activated partial thromboplastin time
Activated plasma thromboplastin time
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silibinin and Activated plasma thromboplastin time
Arterial Blood Gas
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silibinin and Arterial Blood Gas
Arterial line
placement of catheter in artery
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silibinin and Arterial line
BUN
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silibinin and BUN
Biopsy liver
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silibinin and Biopsy liver
Blood Transfusion
Transfusion of blood through a vein
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silibinin and Blood Transfusion
Blood Type and Crossmatch
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silibinin and Blood Type and Crossmatch
Blood, Platelet Count
Platelet Count
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silibinin and Blood, Platelet Count
Bowel Irrigation
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silibinin and Bowel Irrigation
Cardiac monitoring
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silibinin and Cardiac monitoring
Chest X-ray
Radiological technique to image the chest
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silibinin and Chest X-ray
Chromatography–mass spectrometry
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silibinin and Chromatography–mass spectrometry
Complete Blood Count
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silibinin and Complete Blood Count
Complete metabolic panel
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silibinin and Complete metabolic panel
EKG
Electrocardiogram
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silibinin and EKG
ELISA (Enzyme-linked immunosorbent assay)
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silibinin and ELISA (Enzyme-linked immunosorbent assay)
Electron Microscopy
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silibinin and Electron Microscopy
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related medication for 'silibinin'
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21
drugs
10% dextrose
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silibinin and 10% dextrose
atropine
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silibinin and atropine
cimetidine
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silibinin and cimetidine
diazepam
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silibinin and diazepam
dopamine
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silibinin and dopamine
folinic acid
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silibinin and folinic acid
fomepizole
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silibinin and fomepizole
hyperbaric oxygen
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silibinin and hyperbaric oxygen
intravenous benzyl penicillin
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silibinin and intravenous benzyl penicillin
lorazepam
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silibinin and lorazepam
mannitol
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silibinin and mannitol
mars (molecular absorbent regenerating system)
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silibinin and mars (molecular absorbent regenerating system)
methylene blue
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silibinin and methylene blue
metoclopramide
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silibinin and metoclopramide
n-acetylcysteine (nac)
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silibinin and n-acetylcysteine (nac)
norepinephrine
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silibinin and norepinephrine
phenobarbital
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silibinin and phenobarbital
polyethylene glycol
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silibinin and polyethylene glycol
prochlorperazine
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silibinin and prochlorperazine
psilocybin
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silibinin and psilocybin
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web search results for 'silibinin'?
Results
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- silibinin
Silibinin - Wikipedia, the free encyclopedia
Silibinin (INN), also known as silybin, is the major active constituent of ... Retrieved from "http://en.wikipedia.org/wiki/Silibinin" ...
http://en.wikipedia.org/wiki/Silibinin
en.wikipedia.org
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summary
Pilot study of oral silibinin, a putative chemopre...[Clin Cancer Res ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE and other life science journals for biomedical ...
http://www.ncbi.nlm.nih.gov/pubmed/16675592
www.ncbi.nlm.nih.gov
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summary
Silibinin decreases prostate-specific antigen with cell growth ...
Silibinin treatment of cells grown in serum resulted in a significant decrease ... Silibinin-induced G1 arrest was associated with a marked decrease in the kinase ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=22113
www.pubmedcentral.nih.gov
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summary
Grant Abstract
Project Title: Silibinin in Prostate Cancer Chemoprevention & Treatment ... and chemopreventative actions of silibinin, a polyphenolic flavonoid antioxidant ...
http://ods.od.nih.gov/Funding/abstract.aspx?g=5-R01-CA-101008-02
ods.od.nih.gov
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NCI Funded Research Portfolio - 5R01CA102514-05 Abstract
Silibinin also blocks mitogenic signaling, cell cycle progression and growth of ... Our hypothesis is that silibinin targets multiple epigenetic molecular events ...
http://deais.nci.nih.gov/Query/search/details?action=abstrac...
deais.nci.nih.gov
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Complete Milk thistle information from Drugs.com
All about Milk thistle. View complete and up to date Milk thistle ... Silibinin ( Legalon-70 ) enhances the motility of human neutrophils immobilized ...
http://www.drugs.com/npp/milk-thistle.html
www.drugs.com
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Definition of milk thistle - National Cancer Institute Drug Dictionary
... flavonoids such as silibinin, dehydrosilibinin, silychristin and ... The silibinin component of milk thistle has been shown to inhibit growth factor ...
http://www.nci.nih.gov/Templates/drugdictionary.aspx?CdrID=459958
www.nci.nih.gov
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Evaluation of the cancer chemopreventive efficacy ...[Eur J Cancer ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE and ... of oral silibinin, a putative ...
http://www.ncbi.nlm.nih.gov/pubmed/18343654?ordinalpos=4&ito...
www.ncbi.nlm.nih.gov
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Milk thistle (Silybum marianum) - MayoClinic.com
Mayo Clinic offers award-winning medical and health information and tools ... reports from laboratory experiments that the chemicals silymarin and silibinin ...
http://www.mayoclinic.com/health/silymarin/NS_patient-milkthistle
www.mayoclinic.com
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summary
Silymarin as Therapy of Liver Disease
... that are several-fold higher than those achieved with standard silibinin ... the overwhelming majority of silibinin is conjugated, to either a glucuronide or ...
http://www2.niddk.nih.gov/NR/rdonlyres/0AECDEC8-10B4-47A1-A7...
www2.niddk.nih.gov
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silicate
Prev Term: silibinin. Next Term: silicic acid chromatography. silicate. Broader Terms: ... anionic oxides of silicon, the major inorganic components of soil, ...
http://crisp.cit.nih.gov/Thesaurus/00007432.htm
crisp.cit.nih.gov
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summary
NCI Funded Research Portfolio - 5R01CA113876-03 Abstract
Angioprevention of Lung Tumorigenesis by Silibinin ... studies by us show that feeding silibinin, the major active constituent in milk ...
http://deais.nci.nih.gov/Query/search/details?action=abstrac...
deais.nci.nih.gov
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summary
Hepatoprotection - Wikipedia, the free encyclopedia
... of a hepatoprotective medicine is silibinin, derived from Milk Thistle, which ... functions as an explanation for the hepatoprotective properties of silibinin. ...
http://en.wikipedia.org/wiki/Hepatoprotection
en.wikipedia.org
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summary
Effects and mechanisms of silibinin on human hepatoma cell lines.
Silibinin-reduced HuH7 cell growth was associated with significantly up ... We also demonstrated that silibinin increased acetylation of histone H3 and H4 ...
http://www.ncbi.nlm.nih.gov/pubmed/17879397
www.ncbi.nlm.nih.gov
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Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga ...
... principal flavanolignan, silibinin, is preferentially ... Comparative bioavailability of silibinin in healthy male volunteers. Int J Clin Pharmacol Ther. ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1865121
www.pubmedcentral.nih.gov
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summary
Milk Thistle [NCCAM Herbs at a Glance]
Basic information on milk thistle, including common names, uses, potential side ... herb's active components, including silybinin (also called silibinin or silybin) ...
http://nccam.nih.gov/health/milkthistle/
nccam.nih.gov
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Milk Thistle (Silybum marianum)
Used medicinally for functional disorders of the liver and gallbladder. Also used for cases of jaundice, colitis, pleurisy, and diseases of the spleen. Low toxicity herb.
http://www.rxlist.com/cgi/alt/milkthistle_faq.htm
www.rxlist.com
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eMedicine - Toxicity, Mushroom - Amatoxin : Article by Andrew K Chang
Of more than 5000 species of mushrooms in the United States, approximately 100 ... Silibinin (water-soluble milk thistle extract, not available in the United ...
http://www.emedicine.com/emerg/topic818.htm
www.emedicine.com
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Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 ...
Here, we assessed the effect of silibinin on UV-induced DNA damage and p53-p21 ... In other studies, silibinin treatment resulted in a further up-regulation of p53 ...
http://www.ncbi.nlm.nih.gov/pubmed/15033902?dopt=Abstract
www.ncbi.nlm.nih.gov
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flavonoid
See for: silibinin. Broader Terms: benzopyran. Narrower Terms: flavone. Narrower Terms: ... group af aromatic oxygen heterocyclic compounds (phenyl benzopyrans) ...
http://crisp.cit.nih.gov/Thesaurus/00003034.htm
crisp.cit.nih.gov
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summary
Amanita virosa - Wikipedia, the free encyclopedia
Silibinin prevents the uptake of amatoxins by hepatocytes, thereby protecting ... Chemotherapy of Amanita phalloides poisoning with intravenous silibinin" ...
http://en.wikipedia.org/wiki/Amanita_virosa
en.wikipedia.org
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summary
Milk Thistle - National Cancer Institute
Expert-reviewed information summary about the use of milk thistle as a treatment for cancer. ... In the biological literature, silybin is referred to as silibinin. ...
http://www.nci.nih.gov/cancertopics/pdq/cam/milkthistle/Heal...
www.nci.nih.gov
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summary
NCI Funded Research Portfolio - 5R01CA113876-03 Details
Your source for National Cancer Institute funded research grants, contract ... Angioprevention of Lung Tumorigenesis by Silibinin. Institution ...
http://deais.nci.nih.gov/Query/search/details?grantID=7213246&grtSCDC=FY+2007
deais.nci.nih.gov
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summary
Antiproliferative and apoptotic effects of silibin...[Prostate. 2002 ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE and ... Silibinin treatment of H-7 and I-8 ...
http://www.ncbi.nlm.nih.gov/pubmed/12386921?dopt=Abstract
www.ncbi.nlm.nih.gov
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summary
ChemIDPlus/HSDB 22888-70-6 Chemical - National Toxicology Program
Home >> Testing Information >> Testing Status of Agents at NTP >> 22888-70-6 Chemical ... Silibinin. Silliver. Silybine. Silymarin I. Silymarine I. Back to top ...
http://ntp.niehs.nih.gov/index.cfm?objectid=E87E9400-BDB5-82F8-FC337F8F20FA9CA1
ntp.niehs.nih.gov
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summary
Talk:Amanita phalloides - Wikipedia, the free encyclopedia
... with "silymarin amanita" or "silibinin amanita" and you'll find quite ... rather silymarin, a crude extract of milkthistle, or pure flavinoid silibinin. ...
http://en.wikipedia.org/wiki/Talk:Amanita_phalloides
en.wikipedia.org
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plant extract
See for: silibinin. Broader Terms: biological product. Narrower Terms: alginate. Narrower Terms: ... concentrated preparations made from plant material. Term ...
http://crisp.cit.nih.gov/Thesaurus/00006387.htm
crisp.cit.nih.gov
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summary
The cancer preventive flavonoid silibinin causes hypophosphorylation of ...
Here we assessed whether silibinin causes hypophosphorylation of Rb-related ... Silibinin treatment also resulted in 90 and 70% decrease in CDK4 and CDK2 levels, ...
http://www.ncbi.nlm.nih.gov/pubmed/12429923
www.ncbi.nlm.nih.gov
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summary
NCI Funded Research Portfolio - 5R01CA112304-03 Details
Your source for National Cancer Institute funded research grants, contract ... Colon Cancer Chemoprevention by Flavonoid Silibinin. Institution ...
http://deais.nci.nih.gov/Query/search/details?grantID=7189346&grtSCDC=FY+2007
deais.nci.nih.gov
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Question for Rick - Hepatitis C: Support Group at WebMD
I think I'll mosey on over to the health food store and buy me some silibinin... today and I think I'll give MT a try by adding silibinin to my daily regime. ...
http://boards.webmd.com/webx?THDX@@.8977b6e4!thdchild=.8977b6e4
boards.webmd.com
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summary
Definition of phosphatidylcholine-bound silybin - National Cancer ...
Virtual and Standard Colonoscopy Both Accurate. NCI Responds to Hurricanes ... Silybin, also known as silibinin, is a mixture of two stereoisomers, denoted ...
http://www.nci.nih.gov/Templates/drugdictionary.aspx?CdrID=558906
www.nci.nih.gov
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summary
Silibinin induces growth inhibition and apoptotic cell death in human ...
RESULTS: Silibinin (25, 50 and 100 microM) treatment of SHP-77 and A-549 cells ... CONCLUSION: Silibinin significantly induces growth inhibition, a moderate cell ...
http://www.ncbi.nlm.nih.gov/pubmed/12894553
www.ncbi.nlm.nih.gov
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List of drugs: Si - Wikipedia, the free encyclopedia
silibinin (INN) silicristin (INN) silidianin (INN) silperisone (INN) Silphen. siltenzepine (INN) ... This page was last modified on 5 May 2006, at 21:38. ...
http://en.wikipedia.org/wiki/List_of_drugs:_Si
en.wikipedia.org
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CRISP - Computer Retrieval of Information on Scientific Projects ...
Given that obese and type 2 diabetic patients are at risk and these processes ... and pharmacokinetic profile of silibinin at steady state conditions at ...
http://crisp.cit.nih.gov/crisp/CRISP_LIB.getdoc?textkey=7123...
crisp.cit.nih.gov
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Commentary: The optimal management of mushroom poisoning remains ...
Department of Emergency Medicine Cook County Hospital 1900 W Polk St, 10th Floor ... the various antidotes?such as silibinin and thioctic acid [lipoic acid]?proposed ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1071150
www.pubmedcentral.nih.gov
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Milk Thistle May Slow Lung Cancer
A compound from the milk thistle plant might slow the progression ... The compound, called silibinin, hasn't been studied for lung cancer cancer in humans yet. ...
http://www.webmd.com/lung-cancer/news/20060620/milk-thistle-may-slow-lung-cancer
www.webmd.com
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Silymarin inhibits growth and causes regression of established skin ...
Silibinin treatment of cells in culture at 12.5, 25 (plasma level) and 50 microM ... Similar silibinin treatments also resulted in a significant decrease in phospho ...
http://www.ncbi.nlm.nih.gov/pubmed/11895866?dopt=Abstract
www.ncbi.nlm.nih.gov
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Category:Antidotes - Wikipedia, the free encyclopedia
Antidotes are substances used to treat poisonings either by antagonising or by ... Silibinin. Snake-stones. V. Venice treacle ...
http://en.wikipedia.org/wiki/Category:Antidotes
en.wikipedia.org
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antineoplastic
See for: silibinin. Broader Terms: drug /agent. Narrower Terms: 6 thioguanine. Narrower Terms: ... agent that inhibits or prevents the development or ...
http://crisp.cit.nih.gov/Thesaurus/00000509.htm
crisp.cit.nih.gov
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summary
Chemotherapy of Amanita phalloides poisoning with ...[Hum Toxicol. 1983 ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE and ... by silibinin against Amanita ...
http://www.ncbi.nlm.nih.gov/pubmed/6862461
www.ncbi.nlm.nih.gov
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summary
In vitro interaction of the HIV protease inhibitor ritonavir with ...
Silibinin and hyperforin did not significantly alter cellular uptake of ... A similar result was also observed for silibinin when tested in MDR1-MDCK cells. ...
http://www.ncbi.nlm.nih.gov/pubmed/15266218
www.ncbi.nlm.nih.gov
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Category:Flavonoids - Wikipedia, the free encyclopedia
The following 47 pages are in this category, out of 47 total. ... S. Silibinin. Sofalcone. Sterubin. T. Tangeritin. Tannin. Troxerutin ...
http://en.wikipedia.org/wiki/Category:Flavonoids
en.wikipedia.org
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Hepatitis C and CAM [NCCAM Research Report]
This Research Report answers some frequently asked questions on hepatitis C and CAM, reviews findings from scientific ... Effects of silibinin and of a ...
http://nccam.nih.gov/health/hepatitisc/
nccam.nih.gov
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summary
Milk thistle nomenclature: why it matters in cance...[Integr Cancer ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE and ... is derived silibinin, a semipurified ...
http://www.ncbi.nlm.nih.gov/pubmed/17548790
www.ncbi.nlm.nih.gov
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References
Under the Evidence-based Practice Program of the Agency for Healthcare Research ... action of the flavonoid silymarin and of its structural isomer silibinin. ...
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=hstat1.biblist.29350
www.ncbi.nlm.nih.gov
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Executive Summary - Milk Thistle Extract / Silymarin / Silybin
BASIS OF ... Alternative herbal medicines are projected to be a $5 billion ... silibinin; silibinine; silybum substance E; silymarin I. Structural ...
http://ntp-server.niehs.nih.gov/ntp/htdocs/Chem_Background/E...
ntp-server.niehs.nih.gov
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Category:Antioxidants - Wikipedia, the free encyclopedia
The main article for this category is Antioxidant. Wikimedia Commons has ... The following 58 pages are in this category, ... Silibinin. Superoxide ...
http://en.wikipedia.org/wiki/Category:Antioxidants
en.wikipedia.org
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summary
Screening of various phenolic acids and flavonoid ...[Z Naturforsch [C ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 ... diosmin, silibinin, and silymarin) against AChE and BChE at 1 mg/ml ...
http://www.ncbi.nlm.nih.gov/pubmed/18274286?dopt=Abstract
www.ncbi.nlm.nih.gov
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Silybum marianum - Wikipedia, the free encyclopedia
Blessed Milk Thistle (Silybum marianum) is a milk thistle, a plant of the ... Another extract, silibinin or a derivative, is used against poisoning by ...
http://en.wikipedia.org/wiki/Silybum_marianum
en.wikipedia.org
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Cytotoxic fungi--an overview.
Among fungal toxins causing organ damage in the human body, amatoxins and ... is available, but some pharmaceuticals, like silibinin, benzylpenicillin ...
http://www.ncbi.nlm.nih.gov/pubmed/14505933
www.ncbi.nlm.nih.gov
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