Lamivudine (2',3'-dideoxy-3'-thia cytidine , commonly called 3TC ) is a potent nucleoside analog reverse transcriptase inhibitor (nRTI).

It is marketed by GlaxoSmithKline with the brand names Zeffix , Heptovir , Epivir , and Epivir-HBV . more

Lamivudine (2',3'-dideoxy-3'-thia cytidine , commonly called 3TC ) is a potent nucleoside analog reverse transcriptase inhibitor (nRTI).

It is marketed by GlaxoSmithKline with the brand names Zeffix , Heptovir , Epivir , and Epivir-HBV .

Lamivudine has been used for treatment of chronic hepatitis B at a lower dose than for treatment of HIV . It improves the seroconversion of e-antigen positive hepatitis B and also improves histology staging of the liver. Long term use of lamivudine unfortunately leads to emergence of a resistant hepatitis B virus (YMDD) mutant. Despite this, lamivudine is still used widely as it is well tolerated. less