Duloxetine (brand names Cymbalta , Yentreve ) is a serotonin-norepinephrine reuptake inhibitor (SNRI) effective for the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), pain related to diabetic neuropathy , fibromyalgia and stress urinary incontinence (SUI). more

Duloxetine (brand names Cymbalta , Yentreve ) is a serotonin-norepinephrine reuptake inhibitor (SNRI) effective for the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), pain related to diabetic neuropathy , fibromyalgia and stress urinary incontinence (SUI). Duloxetine has been approved in many countries for the above indications, for the exception of stress urinary incontinence in the US. It is manufactured and marketed by Eli Lilly . A study in the American Journal Of Psychiatry concludes that "Duloxetine improved cognition, depression, and some pain measures and was safe and well tolerated in elderly patients with recurrent major depressive disorder." [ 1 ] While others disagree: "Large number of side effects occurring during duloxetine treatment and lack of clear advantage over existing medications prompted several critical reviews concluding that duloxetine "should not be used" for stress urinary incontinence [ 2 ] and "currently has no place in the treatment of depression or diabetic neuropathy" as well. [ 3 ] [ 4 ] However, Cymbalta remains one of the most widely perscribed medications, with hundreds of millions of perscriptions written annually. [ 5 ] less