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decitabine
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what is 'decitabine'?
Definition for decitabine
Decitabine (trade name Dacogen ), or 5-aza-2'-deoxycytidine , is a cytosine analog.
It is a hypomethylating agent . [ 1 ] [ 2 ] It hypomethylates DNA by inhibiting DNA methyltransferase .
more
Decitabine (trade name Dacogen ), or 5-aza-2'-deoxycytidine , is a cytosine analog.
It is a hypomethylating agent . [ 1 ] [ 2 ] It hypomethylates DNA by inhibiting DNA methyltransferase .
It functions in the same way as azacitidine .
Decitabine is indicated for the treatment of myelodysplastic syndromes (MDS) including previously treated and untreated, de novo and secondary MDS of all French-American-British subtypes ( refractory anemia , refractory anemia with ringed sideroblasts , refractory anemia with excess blasts , refractory anemia with excess blasts in transformation , and chronic myelomonocytic leukemia ) and Intermediate-1, Intermediate-2, and High-Risk International Prognostic Scoring System groups.
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diagnoses treated with 'decitabine'
1 - 1 of
1
diagnosis
myelodysplasia
ineffective production of blood cells and predisposition to cancer
web search for:
decitabine and myelodysplasia
related procedures when taking 'decitabine'
1 - 5 of
27
procedures
Biopsy bone marrow
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decitabine and Biopsy bone marrow
Blood, Platelet Count
Platelet Count
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decitabine and Blood, Platelet Count
Bone Marrow Aspiration
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decitabine and Bone Marrow Aspiration
CD55 (decay accelerating factor [DAF])
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decitabine and CD55 (decay accelerating factor [DAF])
CD59 (membrane inhibitor of reactive lysis [MIRL])
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decitabine and CD59 (membrane inhibitor of reactive lysis [MIRL])
CMV serology
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decitabine and CMV serology
Central venous catheter
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decitabine and Central venous catheter
Chromosomal analysis
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decitabine and Chromosomal analysis
Complete Blood Count
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decitabine and Complete Blood Count
Epstein Barr Virus serology
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decitabine and Epstein Barr Virus serology
Fluorescent in situ hybridization (FISH)
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decitabine and Fluorescent in situ hybridization (FISH)
HLA (human leukocyte antigen)
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decitabine and HLA (human leukocyte antigen)
Hematopoietic stem cell transplantation
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decitabine and Hematopoietic stem cell transplantation
Hemoglobin electrophoresis
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decitabine and Hemoglobin electrophoresis
Histocompatibility testing
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decitabine and Histocompatibility testing
Human Immunodeficiency Virus (HIV) serology
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decitabine and Human Immunodeficiency Virus (HIV) serology
Immunosuppressive therapy
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decitabine and Immunosuppressive therapy
Peripheral blood smear
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decitabine and Peripheral blood smear
Polymerase Chain Reaction (PCR)
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decitabine and Polymerase Chain Reaction (PCR)
Reticulocyte count
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decitabine and Reticulocyte count
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related medication for 'decitabine'
1 - 5 of
9
drugs
amifostine
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decitabine and amifostine
azacitidine
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decitabine and azacitidine
cladribine (2-cda)
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decitabine and cladribine (2-cda)
cytosine arabinoside
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decitabine and cytosine arabinoside
diepoxybutane (deb)
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decitabine and diepoxybutane (deb)
erythropoietin
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decitabine and erythropoietin
granulocyte colony-stimulating factor [g-csf])
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decitabine and granulocyte colony-stimulating factor [g-csf])
hydroxyurea
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decitabine and hydroxyurea
lenalidomide
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decitabine and lenalidomide
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The following are types of physicians relevant for 'decitabine'.
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web search results for 'decitabine'?
Results
1 - 50
- decitabine
Decitabine - Wikipedia, the free encyclopedia
Decitabine (trade name Dacogen), or 5-aza-2'-deoxycytidine, is indicated for ... Retrieved from "http://en.wikipedia.org/wiki/Decitabine" ...
http://en.wikipedia.org/wiki/Decitabine
en.wikipedia.org
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summary
Decitabine facts and comparsions at Drugs.com
All about Decitabine. View complete and up to date Decitabine information - part of the Drugs.com trusted medication database.
http://www.drugs.com/cdi/decitabine.html
www.drugs.com
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summary
MedlinePlus Drug Information: Decitabine Injection
Decitabine is used to treat myelodysplastic syndrome (a group of conditions in ... Decitabine is in a class of medications called hypomethylation agents. ...
http://www.nlm.nih.gov/medlineplus/druginfo/meds/a608009.html
www.nlm.nih.gov
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summary
Decitabine (Intravenous Route) - MayoClinic.com
Mayo Clinic offers award-winning medical and health information and tools for healthy living. ... Decitabine is used to treat myelodysplastic syndromes ...
http://www.mayoclinic.com/health/drug-information/DR602349
www.mayoclinic.com
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summary
Decitabine in the treatment of myelodysplastic syndromes
Decitabine, a hypomethylating agent that allows for the re-expression of tumor ... In phase 2 and 3 studies, decitabine has been associated with durable responses ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2376088
www.pubmedcentral.nih.gov
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summary
Definition of decitabine - NCI Dictionary of Cancer Terms
Virtual and Standard Colonoscopy Both Accurate. NCI Responds to Hurricanes. The Nation's Investment in Cancer Research FY 2009 ... decitabine (deh-SIT-uh-been) ...
http://www.nci.nih.gov/Templates/db_alpha.aspx?CdrID=45208
www.nci.nih.gov
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summary
Drug Information for Decitabine IV - WebMD
Find medical information for Decitabine IV including side effects, drug interactions, images and pictures, medication uses, warnings, user ratings and reviews.
http://www.webmd.com/drugs/drug-144319-Decitabine%20IV.aspx?...
www.webmd.com
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summary
Update of the decitabine experience in higher risk myelodysplastic ...
Patients received decitabine 100 mg/m(2) per course every 4 weeks in 3 different ... CONCLUSIONS: The longer term experience with decitabine in MDS was favorable. ...
http://www.ncbi.nlm.nih.gov/pubmed/17133405
www.ncbi.nlm.nih.gov
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summary
Clinical Study: 02-C-0205, Phase I Study of Gene Induction Mediated by ...
Clinical Study Summary Sheet for 02-C-0205 ... Decitabine will be administered by continuous infusion on days 1-4, and patient ...
http://clinicalstudies.info.nih.gov/detail/A_2002-C-0205.html
clinicalstudies.info.nih.gov
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summary
Drug Combination Studied in Leukemias - Yahoo! Health
Cancer researchers are conducting a clinical trial to study a combination of drugs they hope will provide a less toxic ... Decitabine Paired With Valproic Acid ...
http://health.yahoo.com/leukemia-treatment/drug-combination-...
health.yahoo.com
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summary
decitabine medical facts from Drugs.com
Physician reviewed decitabine patient information - includes decitabine description, dosage and directions. ... Decitabine could cause harm to the unborn baby. ...
http://www.drugs.com/mtm/decitabine-injection.html
www.drugs.com
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summary
Decitabine - PubChem Public Chemical Database
PubChem ... Decitabine - Compound Summary (CID: 451668) structure given in first ... Decitabine. Dezocitidine. Dacogen. AzadC. 5-Aza-2'-deoxycytidine. 5 ...
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=451668
pubchem.ncbi.nlm.nih.gov
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summary
Modulation by decitabine of gene expression and growth of osteosarcoma ...
Decitabine is a cytosine analog that inhibits DNA methylation and reactivates silenced genes. Decitabine has shown promising clinical efficacy in the treatment of ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pub...
www.pubmedcentral.nih.gov
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summary
Phase I study of decitabine alone or in combination with valproic acid ...
RESULTS: The OBD of decitabine was 20 mg/m(2)/d intravenously, with limited ... In patients treated with decitabine plus VA, dose-limiting encephalopathy ...
http://www.ncbi.nlm.nih.gov/pubmed/17679729
www.ncbi.nlm.nih.gov
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summary
Images of Decitabine IV - WebMD
View pictures of Decitabine IV including drug dosages and medical information and advice on prescription drugs, vitamins and over the counter medications.
http://www.webmd.com/drugs/drug-144319-Decitabine+IV.aspx?dr...
www.webmd.com
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summary
Clinical Trials (PDQŽ) - National Cancer Institute
Decitabine in Treating Patients With Unresectable Lung ... Phase I Study of Decitabine-Mediated Induction of Tumor Antigen and Tumor ... No previous decitabine ...
http://cancertrials.nci.nih.gov/clinicaltrials/view_clinical...
cancertrials.nci.nih.gov
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summary
Dacogen (decitabine) medical facts from Drugs.com
Physician reviewed Dacogen patient information - includes Dacogen description, dosage and directions. ... Decitabine could cause harm to the unborn baby. ...
http://www.drugs.com/mtm/dacogen-injection.html
www.drugs.com
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summary
Talk:Decitabine - Wikipedia, the free encyclopedia
Decitabine is part of WikiProject Pharmacology, a project to improve all ... Retrieved from "http://en.wikipedia.org/wiki/Talk:Decitabine" ...
http://en.wikipedia.org/wiki/Talk:Decitabine
en.wikipedia.org
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summary
Drug Improves Care of Bone Marrow Disease - Yahoo! Health
The drug, decitabine, is designed to turn on genes that cancer has switched off. ... Decitabine was given fast-track approval by the Food and Drug ...
http://health.yahoo.com/blood-medications/drug-improves-care...
health.yahoo.com
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summary
Characterization of in vitro and in vivo hypomethylating effects of ...
Decitabine and FK-228 were obtained from The National Cancer Institute (NCI) ... Decitabine is a nucleoside analog that was demonstrated to induce global DNA ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1865075
www.pubmedcentral.nih.gov
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summary
Phase I and pharmacodynamic trial of the DNA methyltransferase ...
CONCLUSION: Decitabine can be combined safely with carboplatin at a dose and ... decitabine. Azacitidine. Carboplatin. DNA Modification Methylases ...
http://www.ncbi.nlm.nih.gov/pubmed/17925555?dopt=Abstract
www.ncbi.nlm.nih.gov
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Dacogen Information from Drugs.com
Dacogen information from Drugs.com, includes Dacogen side effects, interactions and indications. ... Decitabine. Dacogen Drug Interactions ...
http://www.drugs.com/dacogen.html
www.drugs.com
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summary
Definition of decitabine - National Cancer Institute Drug Dictionary
decitabine. A cytidine antimetabolite analogue with potential antineoplastic activity. Decitabine incorporates into DNA and inhibits DNA methyltransferase, resulting ...
http://www.nci.nih.gov/Templates/drugdictionary.aspx?CdrID=39299
www.nci.nih.gov
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Demethylating agent - Wikipedia, the free encyclopedia
Azacitidine and decitabine are marketed as VidazaŽ and DacogenŽ respectively. ... Decitabine". Nat Rev Drug Discov 5 (11): 891?2. doi:10.1038/nrd2180. PMID 17117522. ...
http://en.wikipedia.org/wiki/Demethylating_agent
en.wikipedia.org
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New drug for sickle cell disease
... at the University of Chicago have tested the drug decitabine for a 3-month ... All the subjects had less symptoms while taking decitabine. ...
http://rarediseases.about.com/b/2003/12/20/new-drug-for-sickle-cell-disease.htm
rarediseases.about.com
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Clinical Trials (PDQŽ) - National Cancer Institute
Decitabine and FR901228 in Treating Patients With Advanced Lung Cancer, ... Patients will receive a 3-day continuous infusion of decitabine. ...
http://cancertrials.nci.nih.gov/clinicaltrials/view_clinical...
cancertrials.nci.nih.gov
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summary
Decitabine improves patient outcomes in myelodysplastic syndromes ...
Decitabine indirectly depletes methylcytosine and causes hypomethylation of ... Patients treated with decitabine had a trend toward a longer median time to ...
http://www.ncbi.nlm.nih.gov/pubmed/16532500
www.ncbi.nlm.nih.gov
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Decitabine Side Effects | Drugs.com
Comprehensive and accurate Decitabine side effects information for consumers and healthcare professionals. ... side effects for Decitabine may not be reported. ...
http://www.drugs.com/sfx/decitabine-side-effects.html
www.drugs.com
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Myelodysplastic Syndromes Treatment - National Cancer Institute
Expert-reviewed information summary about the treatment of myelodysplastic syndromes. ... Chemotherapy with azacitidine or decitabine. ...
http://cancernet.nci.nih.gov/cancertopics/pdq/treatment/myel...
cancernet.nci.nih.gov
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Efficacy of decitabine in the treatment of patients with chronic ...
Efficacy of decitabine in the treatment of patients with chronic myelomonocytic ... The decitabine adverse event profile seen in CMML patients was similar to ...
http://www.ncbi.nlm.nih.gov/pubmed/17881052
www.ncbi.nlm.nih.gov
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summary
Phase 1/2 study of the combination of 5-aza-2?-deoxycytidine with ...
5-aza-2?-deoxycytidine (decitabine) is a cytosine analog with clinical activity ... In this study of low-dose decitabine and VPA given for 10 days in patients with ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1895437
www.pubmedcentral.nih.gov
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Decitabine
Consult your healthcare professional before taking this drug. Decitabine ... In the absence of progression, delay the decitabine dose up to 2 more wk and ...
http://www.drugs.com/ppa/decitabine.html?printable=1
www.drugs.com
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summary
Myelodysplastic Syndromes
[ 4,5 ] TREATMENT OPTIONS UNDER CLINICAL EVALUATION: Decitabine.[ 6 ] Lenalidomide (CC-5013) ... 2'-deoxycytidine (decitabine) in hematopoietic malignancies. ...
http://www.webmd.com/a-to-z-guides/myelodysplastic-syndromes...
www.webmd.com
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MedlinePlus Drug Information: Drugs beginning with Da
DacogenŽ see Decitabine Injection. Dactinomycin ... Decitabine Injection. DeclomycinŽ see Demeclocycline. DecofedŽ see Pseudoephedrine ...
http://www.nlm.nih.gov/medlineplus/druginfo/drug_Da.html
www.nlm.nih.gov
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Activity of decitabine, a hypomethylating agent, in chronic ...
The aim of the study was to evaluate the activity and safety of decitabine in CMML. ... Decitabine was given at 100 mg/m(2) per course every 4 weeks. ...
http://www.ncbi.nlm.nih.gov/pubmed/17219444?ordinalpos=19&it...
www.ncbi.nlm.nih.gov
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decitabine systemic User Reviews at Drugs.com
Learn more about decitabine systemic. Condition. Reviews. Compare. Avg. Ratings ... Reviews for decitabine systemic. There are no reviews - Be the first ...
http://www.drugs.com/comments/decitabine/
www.drugs.com
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Rare Diseases June 2006 Archive
FDA approval for Dacogen (decitabine) injection for MDS. Wednesday June 21, 2006 ... 2006, the U.S. Food and Drug Administration (FDA) approved Dacogen (decitabine) ...
http://rarediseases.about.com/b/a/2006_06_21.htm
rarediseases.about.com
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GEO Accession viewer
NCBI's Gene Expression Omnibus (GEO) is a public archive and resource for gene ... The epigenetic drug decitabine is a potential re-activator of silenced genes ...
http://www.ncbi.nlm.nih.gov/projects/geo/query/acc.cgi?acc=GSE7454
www.ncbi.nlm.nih.gov
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Myelodysplastic Syndromes
Note: Some citations in the text of this section are followed by a level of evidence. ... azacitidine and decitabine are not fully known, these two nucleosides ...
http://www.webmd.com/a-to-z-guides/myelodysplastic-syndromes...
www.webmd.com
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List of drugs: De - Wikipedia, the free encyclopedia
decitabine (INN) decitropine (INN) declenperone (INN) Declomycin. declopramide (INN) ... This page was last modified on 27 March 2008, at 14:07. ...
http://en.wikipedia.org/wiki/List_of_drugs:_De
en.wikipedia.org
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DACOGEN DECITABINE DRUG INFORMATION DACOGEN
Information for DACOGEN DECITABINE DRUG INFORMATION DACOGEN on Drugs.com. May include images, interactions and related content.
http://www.drugs.com/search.php?is_main_search=1&searchterm=...
www.drugs.com
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Organism
NIAID Home / Chemical/Therapeutic Class Search / Chemical/Therapeutic Class Results ... Decitabine. NSC127716. AIDS# 000616. Links to ChemID Plus by CAS# 2353-33-5 ...
http://chemdb.niaid.nih.gov/struct_search/class/class_many.a...
chemdb.niaid.nih.gov
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Decitabine-induced demethylation of 5' CpG island in GADD45A leads to ...
Decitabine-induced demethylation of 5' CpG island in GADD45A leads to apoptosis ... In vivo affects of decitabine treatment in mice showed that untreated control ...
http://www.ncbi.nlm.nih.gov/pubmed/18472964
www.ncbi.nlm.nih.gov
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Decitabine Drug Interactions - Drugs.com
Decitabine Drug Interactions. Drug-drug and drug-food interactions for Decitabine ... below to view Drug-Drug Interactions with decitabine. Major Interactions ...
http://www.drugs.com/drug-interactions/decitabine_d05788.html
www.drugs.com
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summary
Phase I and pharmacodynamic trial of the DNA methy...[J Clin Oncol ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE and ... CONCLUSION: Decitabine can be ...
http://www.ncbi.nlm.nih.gov/pubmed/17925555?ordinalpos=2&ito...
www.ncbi.nlm.nih.gov
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DAC - Wikipedia, the free encyclopedia
Deutsche Alternative Charts, a listing of the most popular alternative albums ... Decitabine, or 5-aza-2'-deoxycytidine, a DNA-demethylating agent. ...
http://en.wikipedia.org/wiki/DAC
en.wikipedia.org
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Myelodysplastic Syndromes
[ 4,5 ] TREATMENT OPTIONS UNDER CLINICAL EVALUATION: Decitabine.[ 6 ] Lenalidomide (CC-5013) ... 5-azacitidine or decitabine. Lenalidomide for patients with ...
http://www.webmd.com/a-to-z-guides/myelodysplastic-syndromes...
www.webmd.com
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summary
Drug Information Summaries - National Cancer Institute
NCI's drug information summaries provide consumer-friendly information about certain drugs that are approved by the U.S. ... (Decitabine) Dasatinib. Decitabine ...
http://cancernet.nci.nih.gov/cancertopics/druginfo/alphalist
cancernet.nci.nih.gov
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summary
Results of a randomized study of 3 schedules of lo...[Blood. 2007 ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE and ... of the decitabine experience in ...
http://www.ncbi.nlm.nih.gov/pubmed/16882708
www.ncbi.nlm.nih.gov
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Dacogen New Drug Application
Decitabine Drug Information from Drugs.com. Dacogen side effects, interactions, indications ... Dacogen (Decitabine) Injection Complete Response Accepted for ...
http://www.drugs.com/NDA/dacogen_040601.html
www.drugs.com
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