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clofazimine
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what is 'clofazimine'?
Definition for clofazimine
Clofazimine is a fat-soluble riminophenazine dye used in combination with rifampicin and dapsone as multidrug therapy (MDT) for the treatment of leprosy . It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients and Mycobacterium avium paratuberculosis infection in Crohn's disease patients.
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Clofazimine is a fat-soluble riminophenazine dye used in combination with rifampicin and dapsone as multidrug therapy (MDT) for the treatment of leprosy . It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients and Mycobacterium avium paratuberculosis infection in Crohn's disease patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum (ENL). (From AMA Drug Evaluations Annual, 1993, p1619).
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diagnoses treated with 'clofazimine'
1 - 5 of
9
diagnosis
graft versus host reaction
complication of organ transplantation
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clofazimine and graft versus host reaction
acute febrile neutrophilic dermatosis
acute skin disease
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clofazimine and acute febrile neutrophilic dermatosis
erythema dyschromicum perstans
ash colored skin patches
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clofazimine and erythema dyschromicum perstans
idiopathic panniculitis
painful bumps under the skin leading to inflammation of fat in skin
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clofazimine and idiopathic panniculitis
atypical mycobacterial infection
infection by mycobacteria other than tuberculosis
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clofazimine and atypical mycobacterial infection
necrobiosis lipoidica
chronic skin disease often seen in diabetics
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clofazimine and necrobiosis lipoidica
pyoderma gangrenosum
swelling and ulcers on legs
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clofazimine and pyoderma gangrenosum
Melkerson-Rosenthal Syndrome
rare neurological syndrome with recurrent facial paralysis
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clofazimine and Melkerson-Rosenthal Syndrome
leprosy
infectious disease affecting skin nerves and mucous membranes
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clofazimine and leprosy
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related procedures when taking 'clofazimine'
1 - 5 of
49
procedures
Biopsy skin
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clofazimine and Biopsy skin
Liver Function Tests
elevated liver enzymes
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clofazimine and Liver Function Tests
Chest X-ray
Radiological technique to image the chest
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clofazimine and Chest X-ray
Complete Blood Count
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clofazimine and Complete Blood Count
Blood, Platelet Count
Platelet Count
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clofazimine and Blood, Platelet Count
Erythrocyte Sedimentation Rate (ESR)
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clofazimine and Erythrocyte Sedimentation Rate (ESR)
Culture
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clofazimine and Culture
Serum amylase
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clofazimine and Serum amylase
Serum lipase
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clofazimine and Serum lipase
Biopsy
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clofazimine and Biopsy
Biopsy bone marrow
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clofazimine and Biopsy bone marrow
Bone Marrow Aspiration
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clofazimine and Bone Marrow Aspiration
CT chest
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clofazimine and CT chest
CT scan
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clofazimine and CT scan
Complete metabolic panel
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clofazimine and Complete metabolic panel
Peripheral blood smear
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clofazimine and Peripheral blood smear
serum electrolytes
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clofazimine and serum electrolytes
Excision
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clofazimine and Excision
Urinalysis
Examination of urine to detect disease
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clofazimine and Urinalysis
Endoscopy
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clofazimine and Endoscopy
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related medication for 'clofazimine'
1 - 5 of
47
drugs
cyclosporine
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clofazimine and cyclosporine
thalidomide
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clofazimine and thalidomide
infliximab
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clofazimine and infliximab
prednisone
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clofazimine and prednisone
azathioprine
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clofazimine and azathioprine
cyclophosphamide
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clofazimine and cyclophosphamide
mycophenolate
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clofazimine and mycophenolate
antithymocyte globulin
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clofazimine and antithymocyte globulin
dapsone
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clofazimine and dapsone
methotrexate
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clofazimine and methotrexate
methylprednisolone
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clofazimine and methylprednisolone
mycophenolate mofetil
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clofazimine and mycophenolate mofetil
tacrolimus
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clofazimine and tacrolimus
indomethacin
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clofazimine and indomethacin
prednisone(deltasone)
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clofazimine and prednisone(deltasone)
thalidomide(thalomid )
web search for:
clofazimine and thalidomide(thalomid )
chlorambucil
web search for:
clofazimine and chlorambucil
doxycycline
web search for:
clofazimine and doxycycline
etanercept
web search for:
clofazimine and etanercept
pentoxifylline
web search for:
clofazimine and pentoxifylline
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The following are types of physicians relevant for 'clofazimine'.
related types of physicians 'family practitioner, internist, dermatologist'
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web search results for 'clofazimine'?
Results
1 - 50
- clofazimine
Clofazimine - Wikipedia, the free encyclopedia
RxList Clofazimine (most information taken from FDA) v ? d ? e. Antimycobacterials (J04) ... Aldesulfone sodium ? Clofazimine ? Dapsone ? Rifampicin ...
http://en.wikipedia.org/wiki/Clofazimine
en.wikipedia.org
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Lamprene (Clofazimine) drug description - prescription drugs and medications at RxList
Find Lamprene (Clofazimine) medication description and details on prescription drugs. ... contains 50 mg of micronized clofazimine suspended in an oil-wax base. ...
http://www.rxlist.com/cgi/generic/clofazimine.htm
www.rxlist.com
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summary
Clofazimine advanced consumer information | Drugs.com
Clofazimine patient information - advanced edition from the United States Pharmacopoeia. ... Pregnancy?Clofazimine has not been studied in pregnant women. ...
http://www.drugs.com/cons/Clofazimine.html
www.drugs.com
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summary
clofazimine-oral Glossary of Terms with Definitions on MedicineNet.com
clofazimine-oral glossary includes a list of clofazimine-oral related medical definitions and related links on MedicineNet.com
http://www.medicinenet.com/clofazimine-oral/glossary.htm
www.medicinenet.com
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summary
Clofazimine (Oral Route) - MayoClinic.com
Mayo Clinic offers award-winning medical and health information and tools for healthy living. ... Clofazimine may also be used for other problems as determined ...
http://www.mayoclinic.com/health/drug-information/DR600457
www.mayoclinic.com
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summary
Drugs and Treatments - Clofazimine Oral - Patient Handout from WebMD
Information on Clofazimine Oral - Patient Handout. Find the answers you need about over the counter and prescription medications, vitamins and supplements, and much ...
http://www.webmd.com/drugs/drug-8759-Clofazimine+Oral.aspx?d...
www.webmd.com
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summary
WHO | Use of clofazimine for treating ENL reactions in leprosy
The "off-label" use of clofazimine is actively discouraged by WHO because it is ... Novartis letter to doctors about distribution changes for clofazimine ...
http://www.who.int/lep/mdt/clofazimine/en/index.html
www.who.int
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summary
MedDet
Applications submitted to the WHO Secretariat for the 15th WHO ... Lists by country. WHO related links. Other useful sites. Medicine Use(s) : CLOFAZIMINE ...
http://mednet3.who.int/EMLib/DiseaseTreatments/MedicineDetai...
mednet3.who.int
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summary
Cochleates Potentiate the Efficacy of the Antimycobacterial Drug, Clofazimine.
Clofazimine, at dosages commonly used for tuberculosis, is considered to be ... METHODS: Clofazimine-loaded cochleates (CLFCOCH) were prepared by trapping ...
http://gateway.nlm.nih.gov/MeetingAbstracts/102269459.html
gateway.nlm.nih.gov
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summary
Antimicrobial activities of clofazimine and B669 are mediated by lysophospholipids.
... combined therapy with ansamycin, clofazimine, ethambutol, and isoniazid for ... kinase C, in the pro-oxidative interactions of clofazimine with human phagocytes. ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=245536
www.pubmedcentral.nih.gov
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summary
Clofazimine - Wikipédia
Clofazimine. Un article de Wikipédia, l'encyclopédie libre. Aller à : Navigation, Rechercher ... Récupérée de " http://fr.wikipedia.org/wiki/Clofazimine " ...
http://fr.wikipedia.org/wiki/Clofazimine
fr.wikipedia.org
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CLOFAZIMINE - ORAL (Lamprene) side effects, medical uses, and drug interactions.
Read more about the prescription drug CLOFAZIMINE - ORAL. ... clofazimine-oral Index. Glossary. Back to Medications Index ... to clofazimine-oral, Lamprene ...
http://www.medicinenet.com/clofazimine-oral/article.htm
www.medicinenet.com
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summary
eMedicine - Erythema Dyschromicum Perstans : Article by Robert A Schwartz
C. Oswaldo Ramirez of San Salvador, El Salvador, first described erythema dyschromicum perstans (EDP) in 1957.1 He ... deposits of clofazimine in tissues, ...
http://www.emedicine.com/derm/topic132.htm
www.emedicine.com
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summary
The Final Push Strategy to Eliminate Leprosy as a Public Health Problem - Questions and Answers
optimal amount of clofazimine is maintained in the body tissue, even if the patient ... The discoloration caused by clofazimine starts to appear by the ...
http://www.searo.who.int/LinkFiles/FAQ_qa2003hh.pdf
www.searo.who.int
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summary
Drugs and Treatments - Clofazimine Oral - Conditions from WebMD
Information on Clofazimine Oral - Conditions. Find the answers you need about over the counter and prescription medications, vitamins and supplements, and much more.
http://www.webmd.com/drugs/drug-8759-Clofazimine+Oral.aspx?d...
www.webmd.com
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summary
Lamprene Drug Information, Professional
Lamprene Drug Information from Drugs.com. Includes Lamprene side effects, ... treatment of multibacillary leprosy, clofazimine is recommended in combination ...
http://www.drugs.com/mmx/lamprene.html
www.drugs.com
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summary
Management of reactions in Leprosy
Management with clofazimine and corticosteroids ? is indicated in patients with severe ... Continue clofazimine as below. Taper the dose of clofazimine to ...
http://www.who.int/lep/research/Reactions.pdf
www.who.int
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summary
The Final Push Strategy to Eliminate Leprosy as a Public Health Problem
It is based on two or three drugs (rifampicin, clofazimine, and dapsone), used in ... clofazimine in the same dosage as that used for MB patients but given ...
http://whqlibdoc.who.int/hq/2003/WHO_CDS_CPE_CEE_2003.37.pdf
whqlibdoc.who.int
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summary
Prophylactic and postinfection activity of clofazimine against mycobacterium avium-intracellulare (MAC) within ...
... postinfection activity of clofazimine against mycobacterium avium-intracellulare ... Clofazimine (CLF) has been extensively used in antimycobacterial therapy. ...
http://gateway.nlm.nih.gov/MeetingAbstracts/102213946.html
gateway.nlm.nih.gov
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summary
Effects of clofazimine alone or combined with dapsone on neutrophil and lymphocyte functions in normal individuals ...
... concentration range, clofazimine inhibited lymphocyte transformation. ... months' experience in the treatment of leprosy with clofazimine (Lamprene (Geigy) ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?&artid=181995
www.pubmedcentral.nih.gov
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summary
Lamprene Official FDA information, side effects and uses.
Accurate, FDA approved Lamprene information for healthcare professionals and ... Lamprene, clofazimine, is an antileprosy agent available as soft gelatin ...
http://www.drugs.com/pro/lamprene.html
www.drugs.com
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summary
Effective Treatment of Acute and Chronic Murine Tuberculosis with Liposome-Encapsulated Clofazimine
The therapeutic efficacy of liposomal clofazimine (L-CLF) was studied in mice ... were treated with either free clofazimine (F-CLF), L-CLF, or empty liposomes ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?&artid=89336
www.pubmedcentral.nih.gov
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summary
Leprosy in China - Wikipedia, the free encyclopedia
Leprosy was said to be first recognized in the ancient civilizations of China, ... successful multidrug therapy (MDT) using dapsone, rifampicin and clofazimine. ...
http://en.wikipedia.org/wiki/Leprosy_in_China
en.wikipedia.org
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summary
Rifabutin, ethambutol and clarithromycin is superior to rifampin, ethambutol, clofazimine and ciprofloxacin for MAC ...
... superior to rifampin, ethambutol, clofazimine and ciprofloxacin for MAC bacteremia (ctn 010) ... 15 mg/kg daily, clofazimine 100 mg once daily and ...
http://gateway.nlm.nih.gov/MeetingAbstracts/102219120.html
gateway.nlm.nih.gov
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summary
WHO Guidelines for management of severe erythema nodosum leprosum (ENL) reaction
Continue clofazimine as below. ... about 4-6 weeks for clofazimine to take full effect in controlling ENL. ... clofazimine/prednisolone. ...
http://www.who.int/lep/research/WHOenlguide.pdf
www.who.int
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summary
In vitro activity of clofazimine against rapidly growing nonchromogenic mycobacteria.
Anderson R. Enhancement by clofazimine and inhibition by dapsone of ... blind controlled clinical trial of clofazimine in reactive phases of lepromatous ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?&artid=284191
www.pubmedcentral.nih.gov
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summary
Treatment of Tuberculosis and Tuberculosis Infection in Adults and Children
Clofazimine. Combination of beta-Lactam Antibiotics and beta-Lactamase Inhibitors ... Clofazimine inhibits mycobacterial growth and binds preferentially to ...
http://aepo-xdv-www.epo.cdc.gov/wonder/prevguid/p0000413/p0000413.htm
aepo-xdv-www.epo.cdc.gov
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summary
eMedicine - Lupus Erythematosus, Subacute Cutaneous : Article by Jeffrey P Callen, MD
Lupus Erythematosus, Subacute Cutaneous - Subacute cutaneous lupus erythematosus ... controlled clinical trial of clofazimine compared with chloroquine in patients ...
http://www.emedicine.com/DERM/topic248.htm
www.emedicine.com
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summary
WHO | MDT: side effects FAQ
... are the side-effects of clofazimine, such as discolouration and ichthyosis and ... The discolouration caused by clofazimine usually does not cause any serious ...
http://www.who.int/lep/mdt/side_effects/en/index1.html
www.who.int
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summary
Checklist to Ask Your Doctor, on MedicineNet.com
Checklist to Take To Your Doctor's Appointment. Make the most of your doctor's visit. ...
http://www.medicinenet.com/guide.asp?s=rss&a=50586&k=clofazimine-oral_Specialty
www.medicinenet.com
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summary
Multi-drug-resistant tuberculosis - Wikipedia, the free encyclopedia
Chemotherapeutic activity of clofazimine and its analogues against Mycobacterium ... of orally administered clofazimine against intracellular Mycobacterium ...
http://en.wikipedia.org/wiki/Multi-drug_resistant_TB
en.wikipedia.org
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summary
Antituberculosis activities of clofazimine and its new analogs B4154 and B4157.
... multidrug-resistant strains, we investigated clofazimine (CFM) and two of its ... activity of B746, a clofazimine analogue against Mycobacterium avium complex. ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=8851584
www.pubmedcentral.nih.gov
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summary
WHO/WPRO-FAQ about treatment
... daily combination of dapsone and clofazimine is capable of eliminating any ... rifampicin-resistant mutants are killed by the clofazimine/dapsone combination. ...
http://www.wpro.who.int/sites/leprosy/treatment/treatment_faq.htm
www.wpro.who.int
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summary
Antibiotic sensitivity of Mycobacterium avium-intracellulare complex (MAC) strains isolated in Italy from AIDS ...
... patient, was reduced by clofazimine, amikacin, ciprofloxacin, rifabutin and ... the in vitro results and indicated in clofazimine a particularly effective drug. ...
http://gateway.nlm.nih.gov/MeetingAbstracts/102192979.html
gateway.nlm.nih.gov
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summary
The Study Group ___________
In view of existing experience with use of clofazimine, and the ... clofazimine for their field trials on chemotherapy in lepromatous leprosy. ...
http://www.who.int/lep/resources/MDT02.pdf
www.who.int
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Oxidative Stress Increases Susceptibility of Mycobacterium tuberculosis to Isoniazid
Plumbagin and clofazimine, compounds capable of generating superoxide anion, ... Since clofazimine alone has antitubercular activity, the observation of ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pub...
www.pubmedcentral.nih.gov
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WHO | Effectiveness of MDT: FAQ
Why is clofazimine given once a month in addition to the daily dose? ... ensure that the optimal amount of clofazimine is maintained in the body tissue, ...
http://www.who.int/lep/mdt/effectiveness/en/index1.html
www.who.int
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summary
In vivo activity of amikacin alone or in combination with clofazimine or rifabutin or both against acute ...
... or in combination with rifabutin or clofazimine or both, was assessed in the ... Addition of clofazimine increased the activity significantly, but addition of ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?&artid=175876
www.pubmedcentral.nih.gov
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summary
Issues arising in the safety monitoring of a trial of two multidrug regimens for MAC bacteremia in which unexpected ...
... ethambutol, ciprofloxacin, and clofazimine vs clarithromycin, ethambutol and ... Clofazimine. Drug Toxicity. Ethambutol. Humans. Rifabutin. Rifampin ...
http://gateway.nlm.nih.gov/MeetingAbstracts/102220441.html
gateway.nlm.nih.gov
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Cl - Cl index - Drugs.com
Clofazimine. Clofibrate. clofibrate. Clolar. Clolar. Clolar. Clolar. Clomid. Clomid. Clomid ... Result Page: Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 ...
http://www.drugs.com/alpha/c18.html
www.drugs.com
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eMedicine - Leprosy : Article by D Scott Smith, MD, MSc, DTMandH
Leprosy - Leprosy is a chronic infection caused by the acid-fast, rod-shaped ... a multidrug regimen in 1981 that includes rifampicin, dapsone, and clofazimine. ...
http://www.emedicine.com/med/topic1281.htm
www.emedicine.com
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summary
The Return of Thalidomide: New Uses and Renewed Concerns
demonstrated that clofazimine, an anti-leprosy drug introduced ... clofazimine is now a component. of the multidrug therapy (MDT), introduced by WHO in 1981 as ...
http://www.who.int/lep/research/Thalidomide.pdf
www.who.int
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summary
Lamprene side effects (Clofazimine) and drug interactions - prescription drugs and medications at RxList
Learn the potential medication side effects and drug interactions for the drug Lamprene (Clofazimine) at RxList.
http://www.rxlist.com/cgi/generic/clofazimine_ad.htm
www.rxlist.com
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summary
Regimens
3 capsules of clofazimine (100mg X 3) ? 1 tablet of dapsone (100 mg) ... 1 capsule of clofazimine every other day (50 mg) ? 1 tablet of dapsone (50 mg) ...
http://www.who.int/entity/lep/mdt/MDT_Regimens.pdf
www.who.int
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summary
Oxygen metabolism in phagocytes of leprotic patients: enhanced endogenous superoxide dismutase activity and hydroxyl...
The antileprotic agent, clofazimine, significantly increased the generation of ... Clofazimine may be effective in leprosy by chelating Fe2+, with the resultant ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?&artid=271453
www.pubmedcentral.nih.gov
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Mycobacterium avium subspecies paratuberculosis - Wikipedia, the free encyclopedia
Map causes Johne's disease in cattle and other ruminants, and it ... of Rifabutin, clarithromycin and clofazimine as a potential drug therapy for Crohn's. ...
http://en.wikipedia.org/wiki/Mycobacterium_avium_subspecies_paratuberculosis
en.wikipedia.org
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Leprosy Treatment & Medication | Drugs.com
Leprosy treatment options and related medication information. ... Clofazimine. Lamprene. Lamprene. Thalidomide. Thalidomide. Thalomid. THALOMID. Thalomid ...
http://www.drugs.com/condition/leprosy.html
www.drugs.com
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Clinical correlation of antimicrobial susceptibilities for Mycobacterium avium complex (MAC) isolates from AIDS ...
... ciprofloxacin (CI), clarithromycin (CR), clofazimine (CF), ethambutol (ET) and ... or protease inhibitor) 2.28, and use of clofazimine in regimen 0.52. ...
http://gateway.nlm.nih.gov/MeetingAbstracts/102228208.html
gateway.nlm.nih.gov
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summary
Eliminate Leprosy
reaction needing higher dose of clofazimine and separate ... This is due to clofazimine used daily for treating MB. patients. ...
http://www.searo.who.int/LinkFiles/Tools_and_Guidelines_GuidetoEliminateprev.pdf
www.searo.who.int
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Multicenter Laboratory Validation of Susceptibility Testing of Mycobacterium tuberculosis against Classical Second-...
... and newer compounds (amikacin, clofazimine, ofloxacin, and rifabutin) were ... Except for clofazimine and ethionamide, which are considered self-sterilizing, ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?&artid=85522
www.pubmedcentral.nih.gov
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