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cladribine (2-cda)
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what is 'cladribine (2-cda)'?
Definition for cladribine (2-cda)
Cladribine (Leustatin) is a drug used to treat hairy cell leukemia (leukemic reticuloendotheliosis) and multiple sclerosis . Its chemical name is 2-chlorodeoxyadenosine (2CDA).
As a purine analog , it is a synthetic anti-cancer agent that also suppresses the immune system.
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Cladribine (Leustatin) is a drug used to treat hairy cell leukemia (leukemic reticuloendotheliosis) and multiple sclerosis . Its chemical name is 2-chlorodeoxyadenosine (2CDA).
As a purine analog , it is a synthetic anti-cancer agent that also suppresses the immune system. Chemically, it mimics the nucleoside adenosine and thus inhibits the enzyme adenosine deaminase , which interferes with the cell's ability to process DNA. It is easily destroyed by normal cells except for blood cells, with the result that it produces relatively few side effects and results in very little non-target cell loss.
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diagnoses treated with 'cladribine (2-cda)'
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diagnosis
myelodysplasia
ineffective production of blood cells and predisposition to cancer
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cladribine (2-cda) and myelodysplasia
related procedures when taking 'cladribine (2-cda)'
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27
procedures
Biopsy bone marrow
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cladribine (2-cda) and Biopsy bone marrow
Blood, Platelet Count
Platelet Count
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cladribine (2-cda) and Blood, Platelet Count
Bone Marrow Aspiration
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cladribine (2-cda) and Bone Marrow Aspiration
CD55 (decay accelerating factor [DAF])
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cladribine (2-cda) and CD55 (decay accelerating factor [DAF])
CD59 (membrane inhibitor of reactive lysis [MIRL])
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cladribine (2-cda) and CD59 (membrane inhibitor of reactive lysis [MIRL])
CMV serology
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cladribine (2-cda) and CMV serology
Central venous catheter
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cladribine (2-cda) and Central venous catheter
Chromosomal analysis
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cladribine (2-cda) and Chromosomal analysis
Complete Blood Count
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cladribine (2-cda) and Complete Blood Count
Epstein Barr Virus serology
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cladribine (2-cda) and Epstein Barr Virus serology
Fluorescent in situ hybridization (FISH)
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cladribine (2-cda) and Fluorescent in situ hybridization (FISH)
HLA (human leukocyte antigen)
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cladribine (2-cda) and HLA (human leukocyte antigen)
Hematopoietic stem cell transplantation
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cladribine (2-cda) and Hematopoietic stem cell transplantation
Hemoglobin electrophoresis
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Histocompatibility testing
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Human Immunodeficiency Virus (HIV) serology
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cladribine (2-cda) and Human Immunodeficiency Virus (HIV) serology
Immunosuppressive therapy
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cladribine (2-cda) and Immunosuppressive therapy
Peripheral blood smear
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cladribine (2-cda) and Peripheral blood smear
Polymerase Chain Reaction (PCR)
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Reticulocyte count
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related medication for 'cladribine (2-cda)'
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9
drugs
amifostine
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cladribine (2-cda) and amifostine
azacitidine
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cladribine (2-cda) and azacitidine
cytosine arabinoside
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cladribine (2-cda) and cytosine arabinoside
decitabine
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cladribine (2-cda) and decitabine
diepoxybutane (deb)
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cladribine (2-cda) and diepoxybutane (deb)
erythropoietin
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cladribine (2-cda) and erythropoietin
granulocyte colony-stimulating factor [g-csf])
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cladribine (2-cda) and granulocyte colony-stimulating factor [g-csf])
hydroxyurea
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cladribine (2-cda) and hydroxyurea
lenalidomide
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cladribine (2-cda) and lenalidomide
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The following are types of physicians relevant for 'cladribine (2-cda)'.
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web search results for 'cladribine (2-cda)'?
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- cladribine (2-cda)
Cladribine - Wikipedia, the free encyclopedia
... cell leukemia with cladribine (2-chlorodeoxyadenosine) by subcutaneous bolus ... Retreatment with 2-CdA of progressed HCL patients". Leuk. ...
http://en.wikipedia.org/wiki/Cladribine
en.wikipedia.org
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summary
Living with Cancer Chemotherapy
Cladribine (2-CdA) At the Clinical Center referred to as cladribine (KLAD-rih-been) ... 2. Living with Cancer Chemotherapy. Cladribine (2-CdA) Call your NIH ...
http://www.cc.nih.gov/ccc/patient_education/CaTxeng/cladribine.pdf
www.cc.nih.gov
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summary
Cladribine consumer information from Drugs.com
Cladribine patient information. ... Other commonly used names are 2-chlorodeoxyadenosine and 2-CdA . Category. Antineoplastic ...
http://www.drugs.com/cons/Cladribine.html
www.drugs.com
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summary
Hairy Cell Leukemia
... of choice are either cladribine (2-chlorodeoxyadenosine,2-CdA) or pentostatin. ... Gidron A, Tallman MS: 2-CdA in the treatment of hairy cell leukemia: a ...
http://www.webmd.com/cancer/tc/leukemia-hairy-cell-treatment...
www.webmd.com
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summary
Long-term results of the treatment of patients wit...[Cancer. 2008 ...
... this study was to test cladribine (2-CDA) alone and in combination with ... Reduced-dose cladribine (2-CdA) plus mitoxantrone is effective in the treatment ...
http://www.ncbi.nlm.nih.gov/pubmed/18470909
www.ncbi.nlm.nih.gov
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summary
Leukemia, hairy cell: Treatment - Health Professional Information [NCI ...
Cladribine (2-chlorodeoxyadenosine, 2-CdA) given intravenously by continuous ... Cladribine (2-chlorodeoxyadenosine, 2-CdA) and pentostatin are both highly ...
http://health.yahoo.com/leukemia-treatment/leukemia-hairy-ce...
health.yahoo.com
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summary
Hairy Cell Leukemia Treatment - National Cancer Institute
Cladribine (2-chlorodeoxyadenosine, 2-CdA) given intravenously by continuous ... Cladribine (2-chlorodeoxyadenosine, 2-CdA) and pentostatin are both highly ...
http://www.nci.nih.gov/cancertopics/pdq/treatment/hairy-cell...
www.nci.nih.gov
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summary
MedlinePlus Drug Information: Drugs beginning with 0-9
0.9% Sodium Chloride see Sodium Chloride (Catheter Flush) Injection. 2-CdA see Cladribine. 2-chlorodeoxyadenosine see Cladribine. 3TC see Lamivudine ...
http://www.nlm.nih.gov/medlineplus/druginfo/drug_00.html
www.nlm.nih.gov
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summary
Cladribine - PubChem Public Chemical Database
PubChem Compound Summary ... 2-Chloroadenosine. Cladribine. Nucleic Acids, Nucleotides, and ... 2-CdA. 2 Chlorodeoxyadenosine. 2-Chloro-2'-deoxy-beta-adenosine ...
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=20279
pubchem.ncbi.nlm.nih.gov
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summary
Cladribine Drug Information, Professional
Cladribine Drug Information from Drugs.com. Includes Cladribine side effects, interactions and indications. ... 2-chlorodeoxyadenosine and 2-CdA. ...
http://www.drugs.com/MMX/Cladribine.html
www.drugs.com
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summary
Non-Hodgkin's lymphoma : Diseases & Conditions : Discovery Health
Non-Hodgkin's lymphoma is cancer of a type of white blood cell ... medicines, such as cladribine (2-cda, i.e., Leustatin) or fludarabine (i.e., Fludara) ...
http://health.discovery.com/encyclopedias/illnesses.html?chr...
health.discovery.com
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summary
Hairy Cell Leukemia
Note: Some citations in the text of this section are followed by a level of evidence. ... Cladribine (2-chlorodeoxyadenosine, 2-CdA) and pentostatin are both highly ...
http://www.webmd.com/cancer/tc/leukemia-hairy-cell-treatment...
www.webmd.com
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summary
Cladribine in a weekly versus daily schedule for untreated active hairy ...
Cladribine (2-chlorodeoxyadenosine, 2-CdA) treatment-associated infections may ... of the optimal mode of 2-CdA administration, 132 patients with untreated HCL ...
http://www.ncbi.nlm.nih.gov/pubmed/17209059
www.ncbi.nlm.nih.gov
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summary
Cladribine (2-CdA)
Cladribine (2-CdA) Cómo Se. Administra. Mecanismo de. Acción del. Fįrmaco. Efectos ... Cladribine (2-CdA) Series Viviendo con Quimioterapia para el Cįncer ...
http://www.cc.nih.gov/ccc/patient_education/CaTxsp/cladribinesp.pdf
www.cc.nih.gov
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summary
eMedicine - Hairy Cell Leukemia : Article by Emmanuel C Besa
Hairy cell leukemia (HCL) is a chronic lymphoid leukemia that was originally ... (HCL) is 2-chlorodeoxyadenosine (2-CdA) 0.1 mg/kg/d (cladribine, Leustatin) by ...
http://www.emedicine.com/med/topic937.htm
www.emedicine.com
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summary
Definition of cladribine - National Cancer Institute Drug Dictionary
cladribine. A purine nucleoside antimetabolite analogue. ... 2-CdA. Code name: RWJ-26251. Chemical structure names: 2-chloro-2-deoxyadenosine ...
http://www.nci.nih.gov/Templates/drugdictionary.aspx?CdrID=41184
www.nci.nih.gov
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summary
Rituximab combined with cladribine or with cladrib...[Cancer. 2006 ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE and ... (2-CdA) (the RC regimen) or RC plus ...
http://www.ncbi.nlm.nih.gov/pubmed/16948126
www.ncbi.nlm.nih.gov
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summary
MedlinePlus Drug Information: Cladribine
Cladribine ... Cladribine also can cause neurological and kidney damage. ... 2-CdA. 2-chlorodeoxyadenosine. Last Revised - 04/01/2003. Last Reviewed - 08/01/2007 ...
http://www.nlm.nih.gov/medlineplus/druginfo/meds/a693015.html
www.nlm.nih.gov
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summary
Heterogeneity in Primary and Metastatic Prostate Cancer as Defined by ...
... of apoptosis by cladribine (2-CdA), gemcitabine and other chemotherapeutic ... selective effects of doxorubicin and 2-CdA with protection of immature cells. ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pub...
www.pubmedcentral.nih.gov
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summary
Living with Cancer Chemotherapy
This information is selected specifically for patients participating in ... Cladribine (2-CdA) Cyclophosphamide (Cytoxan®) High-Dose Cyclophosphamide (Cytoxan® ...
http://www.cc.nih.gov/ccc/patient_education/CaTxeng/cancerchemo.html
www.cc.nih.gov
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summary
eMedicine - Waldenstrom Hypergammaglobulinemia : Article by Doris Ponce
Waldenstrom macroglobulinemia (WM) is one of the malignant monoclonal ... Ratschiller D, et al. Cladribine (2-CDA) given as subcutaneous bolus injections ...
http://www.emedicine.com/med/topic2395.htm
www.emedicine.com
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summary
Cladribine therapy in refractory celiac disease wi...[Clin ...
... evaluated the effect of cladribine (2-CDA), a purine analogue inducing T-cell ... Treatment consisted of 2-CDA (0.1 mg/kg/day) intravenously for 5 days, given in ...
http://www.ncbi.nlm.nih.gov/pubmed/16979946
www.ncbi.nlm.nih.gov
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summary
Retreatment with 2-CdA of progressed HCL patients.
All have been retreated with 2-CdA and 2 achieved a CR, 1 a PR and the last one ... Substances: Interferon-alpha. Cladribine. PMID: 7820047 [PubMed - indexed ...
http://www.ncbi.nlm.nih.gov/pubmed/7820047
www.ncbi.nlm.nih.gov
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summary
2-Chloro-2'-deoxyadenosine monophosphate residues in DNA enhance ...
Beutler E. Cladribine (2-chlorodeoxyadenosine). Lancet. 1992 Oct 17;340(8825):952?956. ... of hairy cell leukemia with 2-chlorodeoxyadenosine (2-CdA). Blood. ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1137265
www.pubmedcentral.nih.gov
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summary
eMedicine - Myelodysplasia : Article by Sharon M Castellino
Myelodysplasia encompasses a heterogenous group of disorders that result in ... cladribine (2-CdA), growth factors (erythropoietin, granulocyte colony ...
http://www.emedicine.com/ped/topic1526.htm
www.emedicine.com
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summary
Clinical Study: 09-C-0005, Randomized Trial of Cladribine (CdA) with ...
Randomized Trial of Cladribine (CdA) with Simultaneous or Delayed Rituximab to ... Bilirubin less than or equal to 2 unless consistent with Gilbert's (total/direct ...
http://clinicalstudies.info.nih.gov/detail/A_2009-C-0005.html
clinicalstudies.info.nih.gov
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summary
Treatment of children with Langerhans cell histioc...[Am J Hematol ...
Efficacy of continuous infusion 2-CDA (cladribine) in pediatric patients with ... Activity and toxicity of 2-CDA in Langerhans cell histiocytosis: a single ...
http://www.ncbi.nlm.nih.gov/pubmed/11891804
www.ncbi.nlm.nih.gov
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summary
eMedicine - Langerhans Cell Histiocytosis : Article by M Angelica Selim
Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the proliferation of specialized ... infusion 2-CDA (cladribine) in ...
http://www.emedicine.com/derm/topic216.htm
www.emedicine.com
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summary
Haarcelleukemie - Wikipedia
chemotherapie met cladribine (2-CdA) of pentostatine (DCF) ... Als initiele therapie is er de keuze tussen 2-Cladribine (2-CdA) of Pentostatine. ...
http://nl.wikipedia.org/wiki/Haarcelleukemie
nl.wikipedia.org
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summary
Treatment of hairy cell leukemia with cladribine (...[Ann Oncol. 2002 ...
2-chlorodeoxyadenosine (cladribine) in the treatment of hairy cell leukemia and ... of infections after 2-chlorodeoxyadenosine (2-CDA) therapy in patients with ...
http://www.ncbi.nlm.nih.gov/pubmed/12377655
www.ncbi.nlm.nih.gov
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summary
Studies Listed By Protocol Number
Randomized Trial of Cladribine (CdA) with Simultaneous or Delayed Rituximab to ... A Phase 2, Open Label, Crossover Pharmacokinetic and Pharmacodynamic Study to ...
http://isda150.cc.nih.gov/listing.html
isda150.cc.nih.gov
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summary
Hairy cell leukemia: A diagnosis by endoscopic ultrasound guided fine ...
... was in remission for at least 4 years (48 months) following 2-Cda therapy and ... with hairy cell leukemia after treatment with cladribine. J Clin Oncol. ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pub...
www.pubmedcentral.nih.gov
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summary
Viviendo con Quimioterapia para el Cįncer, El Centro Clķnico Warren ...
Esta información fue seleccionada especķficamente para los pacientes que ... Cladribine (2-CdA) Ciclofosfamida (Cytoxan®) Ciclofosfamida de Dosis Alta (Cytoxan® ...
http://www.cc.nih.gov/ccc/patient_education/CaTxsp/cancerchemo_sp.html
www.cc.nih.gov
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summary
eMedicine - Lymphoma, B-Cell : Article by Ajeet Gajra
Non-Hodgkin lymphoma (NHL) is a heterogenous group of lymphoproliferative malignancies with differing patterns of ... [cladribine], abbreviated 2-CDA) ...
http://www.emedicine.com/med/topic1358.htm
www.emedicine.com
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summary
Wikipedia:WikiProject Pharmacology/List of drugs - Wikipedia, the free ...
2'-deoxycoformycin. 2-amino-6-mercaptopurine. 2-amino-6-trifluoromethoxy-benzothiazole. 2-CdA ... cladribine. Claforan. Claravis. Clarinex. Claripel ...
http://en.wikipedia.org/wiki/Wikipedia:WikiProject_Pharmacology/List_of_drugs
en.wikipedia.org
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summary
Infectious complications after 2-chlorodeoxyadenosine therapy.
... after therapy with nucleoside analogs, including 2-chlorodeoxyadenosine (CdA) ... Antineoplastic Agents. Cladribine. PMID: 8641392 [PubMed - indexed for MEDLINE] ...
http://www.ncbi.nlm.nih.gov/pubmed/8641392
www.ncbi.nlm.nih.gov
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summary
?????:????/???? ??? 2: ?????? ? ????????
2 ????? ?????. 3 ???????. 4 ???? ?????. 5 ??????? ????????. 6 ... such as fludarabine, pentostatin, or cladribine (2-chlorodeoxyadenisine; 2-CDA) ...
http://he.wikipedia.org/wiki/%D7%9E%D7%A9%D7%AA%D7%9E%D7%A9:...
he.wikipedia.org
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summary
Precipitous Release of Methyl-CpG Binding Protein 2 and Histone ...
... cell line CEM-CCRF (Fig. 2, lane 1) was treated with 5aC ... and cladribine (CdA)- and 2-chloro-2?-arabino-fluoro-2?-deoxyadenosine (CAFdA)-resistant cells. ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pub...
www.pubmedcentral.nih.gov
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summary
Synthesis and induction of apoptosis in B cell chr...[Carbohydr Res ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE ... cladribine (2-CdA), that are isolated ...
http://www.ncbi.nlm.nih.gov/pubmed/12526837?ordinalpos=21&it...
www.ncbi.nlm.nih.gov
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summary
Institute: National Cancer Institute (NCI)
Randomized Trial of Cladribine (CdA) with Simultaneous or Delayed Rituximab to ... A Phase 2, Open-Label, Two Arm Trial to Evaluate the Efficacy of PF-00299804 in ...
http://clinicalstudies.info.nih.gov/cgi/protinstitute.cgi?NCI.0.html
clinicalstudies.info.nih.gov
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summary
Treatment of Langerhans cell histiocytosis with 2 chlorodeoxyadenosine.
2 CdA appears to be effective in patients with resistant LCH and warrants ... Antimetabolites, Antineoplastic. Cladribine. PMID: 9130627 [PubMed - indexed for ...
http://www.ncbi.nlm.nih.gov/pubmed/9130627
www.ncbi.nlm.nih.gov
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summary
Induction of an apoptotic program in cell-free extracts by 2-chloro-2 ...
... 2?-deoxyadenosine congeners 2-chloro-2?-deoxyadenosine (2CdA, cladribine) and ... Briefly, unprotected (2-CdA) was phosphorylated with POCl3 in trimethyl ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=21379
www.pubmedcentral.nih.gov
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summary
P53, MDM-2, BAX and BCL-2 and drug resistance in c...[Leuk Lymphoma ...
... (CdA), arabinosyl-2-fluoroadenine (F-ara-A), or chlorambucil (CLB) and drug ... chlorambucil but not fludarabine, cladribine or corticosteroids in B cell ...
http://www.ncbi.nlm.nih.gov/pubmed/9389352?ordinalpos=1&itoo...
www.ncbi.nlm.nih.gov
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summary
Expression of deoxycytidine kinase and phosphorylation of 2 ...
... the recently developed antileukaemic compound 2-chlorodeoxyadenosine (CdA) ... Cladribine/metabolism* Colonic Neoplasms/enzymology. Deoxycytidine Kinase ...
http://www.ncbi.nlm.nih.gov/pubmed/7718326
www.ncbi.nlm.nih.gov
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Leustatin consumer information from Drugs.com
Other commonly used names are 2-chlorodeoxyadenosine and 2-CdA . Category. Antineoplastic ... Cladribine has been shown to cause birth defects in mice and rabbits. ...
http://www.drugs.com/cons/leustatin.html
www.drugs.com
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summary
Serum levels of IL-6 type cytokines and soluble IL-6 receptors in ...
... and 38 patients treated with cladribine (2-CdA), as well as in 17 healthy controls. ... in the patients treated with 2-CdA the IL-6 level was significantly ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?&artid=1781813
www.pubmedcentral.nih.gov
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summary
Adenosine Transporter ENT4 Is a Direct Target of EWS/WT1 Translocation ...
At the highest dosage (10 µM), 2-CdA was highly cytotoxic to all cells examined. ... (2-CdA, also known as cladribine), 2-Fluoroadenine-9-?-D-arabinofuranoside (F-ara ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2394657
www.pubmedcentral.nih.gov
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summary
2-chlorodeoxyadenosine (cladribine) in the treatme...[Eur J Haematol ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 ... 2-CdA was equally effective in treatment of newly diagnosed patients and ...
http://www.ncbi.nlm.nih.gov/pubmed/9918312
www.ncbi.nlm.nih.gov
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summary
Application of population pharmacokinetics to cladribine
... half-life of cladribine after a 2-hour infusion with the same anti tumour ... after treatment with 2-chloro-2'-deoxyadenosine (CdA): relation to opportunistic ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1079880
www.pubmedcentral.nih.gov
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summary
Correlation between chromosome damage and apoptosi...[Toxicology. 2002 ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 ... induced in vitro by cladribine (2-CdA) combined with anthracyclines in ...
http://www.ncbi.nlm.nih.gov/pubmed/11836027
www.ncbi.nlm.nih.gov
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summary
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