Chlorpromazine (as chlorpromazine hydrochloride , abbreviated CPZ , marketed in the US as Thorazine , as [ Largactil in UK) is a phenothiazine antipsychotic , and the oldest in the antipsychotic family of drugs. more

Chlorpromazine (as chlorpromazine hydrochloride , abbreviated CPZ , marketed in the US as Thorazine , as [ Largactil in UK) is a phenothiazine antipsychotic , and the oldest in the antipsychotic family of drugs. It is a typical antipsychotic . It is principally used in the treatment of schizophrenia , though it has also been used to treat severe manic episodes in people with bipolar disorder . It has also been proven in stopping uncontrollable hiccups . Synthesized on December 11 , 1950 , chlorpromazine was the first drug developed with a specific antipsychotic action. Its use has been described as the single biggest advance in psychiatric treatment, with a dramatic effect on the prognosis of the inmates of asylums worldwide. It was the prototype for the phenothiazine class, which later grew to comprise several other agents. Its use today has been largely supplanted by the newer atypical antipsychotics such as olanzapine , quetiapine , and risperidone . less