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urokinase
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what is 'urokinase'?
Definition for urokinase - Abbokinase
Urokinase (Abbokinase), also called urokinase-type Plasminogen Activator (uPA), is a serine protease ( EC 3.4.21.73 ). Urokinase was originally isolated from human urine , but is present in several physiological locations, such as blood stream and the extracellular matrix .
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Urokinase (Abbokinase), also called urokinase-type Plasminogen Activator (uPA), is a serine protease ( EC 3.4.21.73 ). Urokinase was originally isolated from human urine , but is present in several physiological locations, such as blood stream and the extracellular matrix . The primary physiological substrate is plasminogen , which is an inactive zymogen form of the serine protease plasmin . Activation of plasmin triggers a proteolysis cascade which, depending on the physiological environment participate in thrombolysis or extracellular matrix degradation. This links urokinase to vascular diseases and cancer.
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diagnoses treated with 'urokinase'
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16
diagnosis
superior vena cava syndrome
syndrome resulting from obstruction of veins draining head and neck
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urokinase and superior vena cava syndrome
hemothorax
blood in sac around lungs
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urokinase and hemothorax
pulmonary infarction
death of lung tissue due to diminished blood supply
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urokinase and pulmonary infarction
Factor V Leiden thrombophilia
inherited clotting problem
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urokinase and Factor V Leiden thrombophilia
deep vein thrombosis
blood clot in large vein
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urokinase and deep vein thrombosis
pulmonary embolism
blood clot in lung artery
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urokinase and pulmonary embolism
Budd-Chiari Syndrome
obstructed liver veins
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urokinase and Budd-Chiari Syndrome
Factor 2 mutation
genetic disorder resulting in increased risk for blood clotting
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urokinase and Factor 2 mutation
antithrombin III deficiency
inherited disorder causing increased clotting in veins
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urokinase and antithrombin III deficiency
arm vein thrombosis
clot in arm vein
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urokinase and arm vein thrombosis
dysplasminogenemia
rare disorder causing increased clotting
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urokinase and dysplasminogenemia
homocystinuria
multisystem metabolic disease due to abnormal methionine metabolism
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urokinase and homocystinuria
lateral sinus thrombosis
blood clot in brain sinus
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urokinase and lateral sinus thrombosis
protein C deficiency
anticlotting factor deficiency causing venous blood clots
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urokinase and protein C deficiency
protein S deficiency
anti clotting factor deficiency causing venous blood clots
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urokinase and protein S deficiency
sagittal sinus thrombosis
blood clot in large sinus in brain
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urokinase and sagittal sinus thrombosis
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related procedures when taking 'urokinase'
1 - 5 of
43
procedures
Impedance plethysmography
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urokinase and Impedance plethysmography
Complete Blood Count
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urokinase and Complete Blood Count
Protein C (antigen and activity)
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urokinase and Protein C (antigen and activity)
Protein S
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urokinase and Protein S
Activated partial thromboplastin time
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urokinase and Activated partial thromboplastin time
Antiphospholipid antibodies
anribodies seen in inappropriate clot formation
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urokinase and Antiphospholipid antibodies
Antithrombin III
clot thinning factor in body
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urokinase and Antithrombin III
Blood, Platelet Count
Platelet Count
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urokinase and Blood, Platelet Count
CT scan
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urokinase and CT scan
CT venography
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urokinase and CT venography
D dimers
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urokinase and D dimers
Factor V Leiden mutation
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urokinase and Factor V Leiden mutation
Lupus anticoagulant
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urokinase and Lupus anticoagulant
Prothrombin Time (PT)
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urokinase and Prothrombin Time (PT)
Duplex sonography
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urokinase and Duplex sonography
Activated Protein C Resistance test
clotting assay to define a cause of increased clotting
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urokinase and Activated Protein C Resistance test
Compression hosiery
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urokinase and Compression hosiery
Contrast Venography
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urokinase and Contrast Venography
Heparin-induced antibody testing
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urokinase and Heparin-induced antibody testing
Inferior Vena Caval Filter
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urokinase and Inferior Vena Caval Filter
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related medication for 'urokinase'
1 - 5 of
18
drugs
warfarin
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urokinase and warfarin
alteplase
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urokinase and alteplase
heparin
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urokinase and heparin
streptokinase
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urokinase and streptokinase
dalteparin
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urokinase and dalteparin
enoxaparin
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urokinase and enoxaparin
fondaparinux sodium
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urokinase and fondaparinux sodium
tenecteplase
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urokinase and tenecteplase
tinzaparin
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urokinase and tinzaparin
tpa
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urokinase and tpa
rpa
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urokinase and rpa
ardeparin (normiflo)
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urokinase and ardeparin (normiflo)
certoparin (sandoparin)
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urokinase and certoparin (sandoparin)
dalteparin (fragmin)
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urokinase and dalteparin (fragmin)
enoxaparin(lovenox andclexane)
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urokinase and enoxaparin(lovenox andclexane)
nadroparin (fraxiparin)
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urokinase and nadroparin (fraxiparin)
reviparin (clivarin)
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urokinase and reviparin (clivarin)
tinzaparin (innohep and logiparin)
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urokinase and tinzaparin (innohep and logiparin)
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The following are types of physicians relevant for 'urokinase'.
related types of physicians 'family practitioner, internist, pulmonary critical care, pulmonologist'
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web search results for 'urokinase'?
Results
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- Urokinase
Urokinase - Wikipedia, the free encyclopedia
The most important inhibitors of urokinase are the serpins plasminogen activator ... Plasmin · tPA/urokinase · PAI-1/2 · ?2-AP · ?2-macroglobulin · TAFI. v ? d ? e ...
http://en.wikipedia.org/wiki/Urokinase
en.wikipedia.org
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UROKINASE - INJECTION (Abbokinase) side effects, medical uses, and drug ...
Read more about the prescription drug UROKINASE - INJECTION. ... Urokinase should be given within 6 hours of the first symptoms of a heart attack ...
http://www.medicinenet.com/urokinase-injection/article.htm
www.medicinenet.com
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summary
Drug Information for Urokinase Inj - WebMD
Find medical information for Urokinase Inj including side effects, drug interactions, images and pictures, medication uses, warnings, user ratings and reviews.
http://www.webmd.com/drugs/drug-3485-Urokinase+Inj.aspx?drug...
www.webmd.com
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summary
Kinlytic (Urokinase Injection) Drug Information: Uses, Side Effects ...
Learn about the prescription medication Kinlytic (Urokinase Injection), drug uses, dosage, side effects, drug interactions, warnings, and patient labeling.
http://www.rxlist.com/kinlytic-drug.htm
www.rxlist.com
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summary
Abbokinase (urokinase) medical facts from Drugs.com
Physician reviewed Abbokinase patient information - includes Abbokinase description, ... Urokinase is a man-made product developed using a protein that occurs ...
http://www.drugs.com/mtm/abbokinase.html
www.drugs.com
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Urokinase Separation from Cell Culture Broth of a Human Kidney Cell Line
The level of urokinase secreted by the cell line reached to about 145 Plough ... Moreover, urokinase production per unit confluent area and per unit time must be ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1657086
www.pubmedcentral.nih.gov
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summary
Urokinase (Intravenous Route) - MayoClinic.com
Mayo Clinic offers award-winning medical and health information and tools for healthy living. ... Urokinase is used to dissolve blood clots that have formed in ...
http://www.mayoclinic.com/health/drug-information/DR602393/METHOD=print
www.mayoclinic.com
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summary
Plasminogen activator, urokinase receptor (PLAUR)
Human protein-coding gene PLAUR. Represented by 323 ESTs from 156 cDNA libraries. ... Human variant urokinase plasminogen activator receptor (uPAR2) mRNA, partial cds ...
http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=466871
www.ncbi.nlm.nih.gov
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summary
Urokinase-Type Plasminogen Activator - PubChem Public Chemical Database
PubChem Compound Summary ... Urokinase-Type Plasminogen Activator. Enzymes and Coenzymes. Enzymes. Hydrolases ... Urokinase (JP15/USAN/INN) D03341. 9039-53-6 ...
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=17397491
pubchem.ncbi.nlm.nih.gov
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summary
Reduced in vitro release of the urokinase receptor in human ...
... in vitro release of the urokinase receptor in human immunodeficiency virus-1 infected patients. ... urokinase-type plasminogen activator receptors. Other ...
http://gateway.nlm.nih.gov/MeetingAbstracts/ma?f=102255023.html
gateway.nlm.nih.gov
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summary
Urokinase receptor - Wikipedia, the free encyclopedia
Besides the primary ligand urokinase, uPAR interacts with several other proteins, ... The urokinase plasminogen activator receptor in the regulation of the actin ...
http://en.wikipedia.org/wiki/Urokinase_receptor
en.wikipedia.org
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summary
Images of Urokinase Inj - WebMD
View pictures of Urokinase Inj including drug dosages and medical information and advice on prescription drugs, vitamins and over the counter medications.
http://www.webmd.com/drugs/drug-3485-Urokinase+Inj.aspx?drug...
www.webmd.com
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summary
Plasminogen activator, urokinase receptor (Plaur)
Norway rat protein-coding gene Plaur. Represented by 3 ESTs from 3 cDNA libraries. ... Rattus norvegicus plasminogen activator, urokinase receptor, mRNA (cDNA clone ...
http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Rn&CID=82711
www.ncbi.nlm.nih.gov
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summary
A ligand-free, soluble urokinase receptor is present in the ascitic ...
Effects of urokinase receptor occupancy on plasmin generation and proteolysis of ... The receptor for urokinase type plasminogen activator polarizes expression of ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=288394
www.pubmedcentral.nih.gov
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summary
Plasminogen activator, urokinase receptor (Plaur)
Mouse protein-coding gene Plaur. Represented by 83 ESTs from 42 cDNA libraries. ... Mus musculus plasminogen activator, urokinase receptor, mRNA (cDNA clone ...
http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=1359
www.ncbi.nlm.nih.gov
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summary
User Reviews and Drug Ratings for Urokinase Inj - WebMD
Read user ratings and reviews for Urokinase Inj including side effects and drug interactions, medication effectiveness, ease of use and satisfaction.
http://www.webmd.com/drugs/drugreview-3485-Urokinase+Inj.asp...
www.webmd.com
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summary
Amelioration of immune complex-mediated glomerulonephritis by synthetic ...
... induced cell fusion and to inhibit plasmin, urokinase, thrombin, and trypsin. ... by new chromogenic substrates for kallikreins and urokinase. Haemostasis. ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1899758
www.pubmedcentral.nih.gov
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summary
Plasminogen activator, urokinase (PLAU)
Cow protein-coding gene PLAU. Represented by 61 ESTs from 27 cDNA libraries. ... Bos taurus plasminogen activator, urokinase, mRNA (cDNA clone MGC:139972 IMAGE: ...
http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Bt&CID=2519
www.ncbi.nlm.nih.gov
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summary
Myeloperoxidase and Plasminogen Activator Inhibitor 1 Play a Central ...
The activity of urokinase in the infarct zone after AMI was determined by ... We postulated that the increase in urokinase activity in the WT myocardium could ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2193831
www.pubmedcentral.nih.gov
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summary
Plasminogen activator, urokinase (Plau)
Mouse protein-coding gene Plau. Represented by 7 ESTs from 6 cDNA libraries. ... Mus musculus plasminogen activator, urokinase, mRNA (cDNA clone MGC:155950 IMAGE: ...
http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=4183
www.ncbi.nlm.nih.gov
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summary
www.cc.nih.gov/about/ar_archives/ar99/Z01CL-00193-02.htm
... of Project: Role of Urokinase Plasminogen Activator in Acute Pulmonary ... Urokinase plasminogen activator (UPA) is an important molecule in the conversion ...
http://www.cc.nih.gov/about/ar_archives/ar99/Z01CL-00193-02.htm
www.cc.nih.gov
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summary
Increased Plasminogen Activator (Urokinase) in Tissue Culture After ...
... these effects influenced urokinase levels, enhanced yields were ... The isolation and characterization of plasminogen activators (urokinase) from human urine. ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=302329
www.pubmedcentral.nih.gov
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summary
Plasminogen activator, urokinase (PLAU)
Human protein-coding gene PLAU. Represented by 556 ESTs from 206 cDNA libraries. ... sapiens mRNA for urokinase plasminogen activator preproprotein variant ...
http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=77274
www.ncbi.nlm.nih.gov
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summary
Urokinase alfa - PubChem Public Chemical Database
PubChem Compound Summary ... Depositor-Supplied Synonyms: (Total: 6) Sort: Urokinase alfa. r-UK. r-UK (TN) Urokinase alfa (USAN/INN) D06270. 99821-47-3 ...
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=47207928
pubchem.ncbi.nlm.nih.gov
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summary
Induction of the Angiogenic Phenotype by Hox D3
cDNA probe for human urokinase plasminogen activator (uPA) was kindly provided ... Vitt CR, Zandonella CL, Stratton-Thomas JR, Shumna MA, Rosenberg S. Urokinase ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=9314544
www.pubmedcentral.nih.gov
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summary
Urokinase-type plasminogen activator (LOC100008633)
Rabbit protein-coding gene LOC100008633. Corresponds to reference sequence NM_001082011.1. ... Oryctolagus cuniculus urokinase-type plasminogen activator ...
http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Ocu&CID=2313
www.ncbi.nlm.nih.gov
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summary
?-Enolase Resides on the Cell Surface of Mycoplasma fermentans and ...
... enhanced Plg activation by the urokinase-type Plg activator, and the induction ... and invades HeLa cells: involvement of plasminogen and urokinase. Infect. ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2168360
www.pubmedcentral.nih.gov
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summary
NCBI CDD cd00117
CDD is a protein domain classification resource of the National ... Structure-function relationships in the receptor for urokinase-type plasminogen activator. ...
http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00117
www.ncbi.nlm.nih.gov
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summary
Plasminogen activator inhibitor-1 polymers, induced by inactivating ...
During incubation with urokinase-type plasminogen activator, the polymers were ... proteolytic susceptibility of urokinase-type plasminogen activator implicates ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1223451
www.pubmedcentral.nih.gov
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PubMed Link Image
... variant of mRNA for the human receptor for urokinase plasminogen activator. ... Messenger 0 Receptors, Cell Surface 0 Receptors, Urokinase Plasminogen Activator ...
http://www.ncbi.nlm.nih.gov/pubmed/8392005
www.ncbi.nlm.nih.gov
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The fibrinolytic system facilitates tumor cell migration across the ...
Low levels of urokinase plasminogen activator components in basal cell carcinoma ... by regulating the interaction between the urokinase receptor and vitronectin. ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=14...
www.pubmedcentral.nih.gov
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Endothelium and disordered fibrin turnover in the injured lung: newly ...
... newly recognized posttranscriptional and urokinase-dependent pathways by which ... in the lung is mainly attributable to urokinase plasminogen activator (uPA) ...
http://www.ncbi.nlm.nih.gov/pubmed/12004248
www.ncbi.nlm.nih.gov
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summary
Note: Clot Formation by Group A Streptococci
... days and can be lysed on addition of exogenous streptokinase or urokinase. ... streptokinase or 0.13 U of human urokinase (Sigma) to the clot formed in human ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=108206
www.pubmedcentral.nih.gov
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Text mining of full-text journal articles combined with gene expression ...
... cell motility and nuclear factor kB-mediated secretion of urokinase type ... Urokinase plasminogen activator system: a multifunctional role in tumor ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pub...
www.pubmedcentral.nih.gov
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PubMed Link Image
489-94 Urokinase digestion of maleinated plasminogen results in cleavage of the ... Weight Plasmin Plasminogen analysis Urokinase-Type Plasminogen Activator Valine ...
http://www.ncbi.nlm.nih.gov/pubmed/122932
www.ncbi.nlm.nih.gov
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Colloquium PaperRegenerative Medicine: Little evidence of bone marrow ...
... three models: (i) carbon tetrachloride (CCl4) treatment, (ii) albumin-urokinase ... tetrachloride; TgN(Alb1Plau), albumin-urokinase transgenic mouse; TgN(Alb1HBV) ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=304097
www.pubmedcentral.nih.gov
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Identification of SLURP-1 as an epidermal neuromodulator explains the ...
Urokinase-Type Plasminogen Activator/isolation & purification. Urokinase-Type Plasminogen Activator/pharmacology. Xenopus laevis/physiology. Substances: ...
http://www.ncbi.nlm.nih.gov/pubmed/14506129
www.ncbi.nlm.nih.gov
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summary
Host-Specific Response to HCV Infection in the Chimeric SCID-beige/Alb ...
... immunodeficiency disorder (SCID)-beige/albumin (Alb)-urokinase plasminogen ... urokinase plasminogen activator. Note Added in Proof ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1480599
www.pubmedcentral.nih.gov
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The influence of the nature of the asparagine 289-linked ...
The activation kinetics for urokinase (UK) of each of the purified HPgs, as well ... The control of the urokinase-catalyzed activation of human glutamic acid 1 ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=293581
www.pubmedcentral.nih.gov
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summary
PMID 2429783
... recombinant single-chain urokinase-type plasminogen activator in patients with ... dosage adverse effects Urokinase-Type Plasminogen Activator administration ...
http://www.ncbi.nlm.nih.gov/pubmed/2429783
www.ncbi.nlm.nih.gov
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summary
Tissue plasminogen activator in central nervous system physiology and ...
... type plasminogen activator, uPA: urokinase-type plasminogen activator, PAI-1: ... There are two mammalian PAs: tissue-type (tPA) and urokinase-type (uPA) (3) ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1383744
www.pubmedcentral.nih.gov
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Modulation of PAI-1 and tPA activity and thrombolytic effects of corilagin.
Urokinase-Type Plasminogen Activator/pharmacology. Urokinase-Type Plasminogen Activator/therapeutic use. Substances: Glucosides. Plant Extracts ...
http://www.ncbi.nlm.nih.gov/pubmed/14750026?ordinalpos=25&it...
www.ncbi.nlm.nih.gov
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summary
Inhibition of Histone Deacetylase Activity Promotes Invasion of Human ...
... of Human Cancer Cells through Activation of Urokinase Plasminogen Activator (uPA) ... in differential regulation of urokinase plasminogen activator (uPA) gene ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pub...
www.pubmedcentral.nih.gov
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summary
New developments in thrombolytic therapy.
These include streptokinase, urokinase, recombinant tissue-type plasminogen ... urokinase-type plasminogen activator is more fibrin-specific than urokinase. ...
http://www.ncbi.nlm.nih.gov/pubmed/2129372
www.ncbi.nlm.nih.gov
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Clinical value of extended biologic staging by bone marrow ...
The urokinase-type plasminogen activator (uPA) system is of major biologic ... Urokinase plasminogen activator receptor (uPA-R): one potential characteristic ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1191148
www.pubmedcentral.nih.gov
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Urokinase-type plasminogen activator-deficient mice are predisposed to ...
Urokinase-type plasminogen activator (uPA) is thought to be an important ... Urokinase-Type Plasminogen Activator. Grant Support: CA 23753/CA/NCI NIH HHS ...
http://www.ncbi.nlm.nih.gov/pubmed/9006351
www.ncbi.nlm.nih.gov
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Persistent Activation of Mitogen-Activated Protein Kinases p42 and p44 ...
... with activation of the CSF-1 target urokinase plasminogen activator (uPA) gene. ... persistent expression of specific genes, for example, the urokinase ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=109100
www.pubmedcentral.nih.gov
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Solitary Lung Tumors and Their Spontaneous Metastasis in Athymic Nude ...
... as matrix metalloproteinases (MMPs) or urokinase-type ... The urokinase-type plasminogen activator system in cancer metastasis: a review. Int J Cancer. ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1550292
www.pubmedcentral.nih.gov
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Kringles: modules specialized for protein binding. Homology of the ...
Prothrombin, plasminogen, urokinase- and tissue-type plasminogen activators ... Urokinase-Type Plasminogen Activator. Substances: Fibronectins. Parathyroid Hormone ...
http://www.ncbi.nlm.nih.gov/pubmed/6373375
www.ncbi.nlm.nih.gov
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Natural health products that inhibit angiogenesis: a potential source ...
... growth factor (egf) stimulates urokinase-type plasminogen activator (upa) ... curcumin inhibit egf-stimulated urokinase production and phosphorylation of egfr. ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1891180
www.pubmedcentral.nih.gov
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