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saquinavir
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what is 'saquinavir'?
Definition for Saquinavir
Saquinavir is an antiretroviral drug used in HIV therapy. It falls in the protease inhibitor class. Two formulations have been marketed:
Both formulations are generally used as a component of highly active antiretroviral therapy (HAART).
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Saquinavir is an antiretroviral drug used in HIV therapy. It falls in the protease inhibitor class. Two formulations have been marketed:
Both formulations are generally used as a component of highly active antiretroviral therapy (HAART).
Saquinavir was the first protease inhibitor (and sixth antiretroviral) approved by the Food and Drug Administration (FDA). It was approved on December 6 , 1995 , as Invirase, a poorly-absorbed hard gel capsule which quickly led to viral resistance in many of the pioneer patients. The manufacturer, Roche , is alleged to have rushed Invirase to market, but the conditions that prevailed at the time were very bad and there was a lot of pressure to produce products quickly.
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diagnoses treated with 'saquinavir'
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human immunodeficiency virus infections
HIV infections
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Saquinavir and human immunodeficiency virus infections
related procedures when taking 'saquinavir'
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99mTc MAG3 renal scan
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Saquinavir and 99mTc MAG3 renal scan
APTIMA HIV-1 RNA Qualitative Assay
test to detect HIV-1 before the appearance of antibodies to HIV-1
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Saquinavir and APTIMA HIV-1 RNA Qualitative Assay
Abdominal CAT Scan
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Saquinavir and Abdominal CAT Scan
Abdominal ultrasonography
Ultrasound of abdominal contents
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Saquinavir and Abdominal ultrasonography
Automated recombinant phenotypic assays
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Saquinavir and Automated recombinant phenotypic assays
BUN
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Saquinavir and BUN
Biopsy
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Saquinavir and Biopsy
Blood, Platelet Count
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Saquinavir and Blood, Platelet Count
Brain MRI
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Saquinavir and Brain MRI
CD3 T cells
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Saquinavir and CD3 T cells
CD4 /CD8 cell ratio
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Saquinavir and CD4 /CD8 cell ratio
CD4 T cells
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Saquinavir and CD4 T cells
CD8 T cells
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Saquinavir and CD8 T cells
CT brain
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Saquinavir and CT brain
CT kidneys
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Saquinavir and CT kidneys
CT scan
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Saquinavir and CT scan
Central venous catheter
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Saquinavir and Central venous catheter
Cesarean Section
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Saquinavir and Cesarean Section
Complete Blood Count
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Saquinavir and Complete Blood Count
Complete metabolic panel
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Saquinavir and Complete metabolic panel
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related medication for 'saquinavir'
1 - 5 of
44
drugs
ritonavir
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Saquinavir and ritonavir
abacavir
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Saquinavir and abacavir
aerosolized pentamidine
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Saquinavir and aerosolized pentamidine
amprenavir
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Saquinavir and amprenavir
atazanavir
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Saquinavir and atazanavir
atovaquone
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Saquinavir and atovaquone
azithromycin
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Saquinavir and azithromycin
clarithromycin
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Saquinavir and clarithromycin
clindamycin
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Saquinavir and clindamycin
dapsone
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Saquinavir and dapsone
darunavir
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Saquinavir and darunavir
delavirdine
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Saquinavir and delavirdine
didanosine
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Saquinavir and didanosine
efavirenz
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Saquinavir and efavirenz
emtricitabine
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Saquinavir and emtricitabine
enfuvirtide
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Saquinavir and enfuvirtide
ethambutol
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Saquinavir and ethambutol
fosamprenavir
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Saquinavir and fosamprenavir
hepatitis a vaccine
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Saquinavir and hepatitis a vaccine
inactivated poliovirus vaccine
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Saquinavir and inactivated poliovirus vaccine
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web search results for 'saquinavir'?
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- Saquinavir
Saquinavir - Wikipedia, the free encyclopedia
Saquinavir is an antiretroviral drug used in HIV therapy. ... Nelfinavir ? Ritonavir ? Saquinavir ? Tipranavir ? Amprenavir? ? Indinavir ...
http://en.wikipedia.org/wiki/Saquinavir
en.wikipedia.org
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summary
saquinavir (Invirase, Fortovase) Drug Information by MedicineNet.com
Read about saquinavir (Invirase, Fortovase) a drug used for treating HIV (human ... Saquinavir blocks the activity of protease and results in the formation of ...
http://www.medicinenet.com/saquinavir/article.htm
www.medicinenet.com
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MedlinePlus Drug Information: Saquinavir
Saquinavir ... soft gelatin capsules all contain saquinavir, but can not be substituted for ... to the other brand of saquinavir unless your doctor tells you ...
http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a696001.html
www.nlm.nih.gov
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AIDSinfo - HIV/AIDS Drug Information - Saquinavir mesylate
... the decreased demand for saquinavir, the manufacturer discontinued this ... If you are currently taking saquinavir, talk to your doctor about alternative ...
http://www.aidsinfo.nih.gov/drugs/htmldrug_nt.asp?int_id=0164
www.aidsinfo.nih.gov
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summary
Invirase (Saquinavir Mesylate) drug description - prescription drugs and medications at RxList
Find Invirase (Saquinavir Mesylate) medication description and details on prescription drugs. ... INVIRASE brand of saquinavir mesylate is an inhibitor of the human ...
http://www.rxlist.com/cgi/generic/saquin.htm
www.rxlist.com
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saquinavir medical facts from Drugs.com
Physician reviewed saquinavir patient information - includes saquinavir description, dosage and directions. ... medicines that can interact with saquinavir. ...
http://www.drugs.com/mtm/saquinavir.html
www.drugs.com
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summary
Saquinavir - Yahoo! Health
Saquinavir prevents HIV from maturing. ... Some drugs are not recommended to be taken with saquinavir. ... Do not take saquinavir without first talking to your ...
http://health.yahoo.com/hiv-medications/saquinavir/healthwise--d03860a1.html
health.yahoo.com
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summary
Saquinavir mesylate
Although the two drugs are very similar, saquinavir. mesylate offers key advantages over saquinavir, ... of saquinavir is 1,200 mg (taken as six 200-mg ...
http://aidsinfo.nih.gov/DrugsNew/pdfdrug_nt.asp?int_id=164
aidsinfo.nih.gov
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summary
Drugs and Treatments - Saquinavir Mesylate Oral - Patient Handout from WebMD
Find information on WebMD including drug user ratings, drug interactions, medication warnings, medical uses, side effects and recommended dosage.
http://www.webmd.com/drugs/drug-12029-Saquinavir+Mesylate+Or...
www.webmd.com
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summary
Direct Evidence that Saquinavir Is Transported by Multidrug Resistance-Associated Protein (MRP1) and Canalicular ...
... (MDCKII-MRP2) were used to investigate saquinavir's cytotoxicity and transport in ... of GF120918 and increasing saquinavir concentrations, the MDCKII-MRP1 (50 ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=128726
www.pubmedcentral.nih.gov
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summary
Saquinavir (Oral Route) - MayoClinic.com
Mayo Clinic offers award-winning medical and health information and tools for healthy living. ... Saquinavir is used, usually in combination with other HIV ...
http://www.mayoclinic.com/health/drug-information/DR601523
www.mayoclinic.com
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summary
saquinavir
Prev Term: SAPK. Next Term: saralasin. saquinavir. Used for: Invirase. See for: Ro31-8959-003 ... HIV protease inhibitor which acts as an analog of an HIV ...
http://crisp.cit.nih.gov/Thesaurus/00017849.htm
crisp.cit.nih.gov
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summary
SAQUINAVIR MESYLATE
Saquinavir Mesylate ... FortovaseSaquinavir cannot be interchanged with saquinavir mesylate ( Invirase) ... who received saquinavir in combination with ...
http://www.drugs.com/search.php?is_main_search=1&searchterm=SAQUINAVIR+MESYLATE
www.drugs.com
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summary
VALIDATION GUIDELINES
Saquinavir mesilate capsules should be kept in a well-closed container, ... saquinavir (retention time = about 21 minutes) and the peak of similar size with ...
http://www.who.int/medicines/areas/quality_safety/safety_eff...
www.who.int
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saquinavir Glossary of Terms with Definitions on MedicineNet.com
saquinavir glossary includes a list of saquinavir related medical definitions and related ... that appear in the saquinavir, Invirase, Fortovase article. ...
http://www.medicinenet.com/saquinavir/glossary.htm
www.medicinenet.com
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summary
MedlinePlus Medicinas: Saquinavir
Saquinavir ... si usted es alérgico al saquinavir, a otros medicamentos o a cualquiera ... también pueden interactuar con saquinavir, por eso asegúrse de decirle ...
http://www.nlm.nih.gov/medlineplus/spanish/druginfo/medmaster/a696001-es.html
www.nlm.nih.gov
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summary
Saquinavir - Wikipedia, la enciclopedia libre
Saquinavir es un antiretroviral de la familia de los inhibidor de la proteasa. ... El saquinavir inhibe a la enzima, cono lo que se evita la replicación viral y la ...
http://es.wikipedia.org/wiki/Saquinavir
es.wikipedia.org
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summary
AIDSinfo - HIV/AIDS Drug Information - Saquinavir mesylate
Saquinavir was approved by the FDA on November 7, 1997. ... Saquinavir mesylate, marketed as Invirase, must be combined with ritonavir to ...
http://aidsinfo.nih.gov/drugs/htmldrug_tech.asp?int_id=0164
aidsinfo.nih.gov
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summary
NTP: Abstract for IMM97001: Saquinavir
... NTP Study Types >> Immunology >> Abstracts >> Abstract for IMM97001: Saquinavir ... Saquinavir (SQV) is a protease inhibitor targeted to interfere late in ...
http://ntp.niehs.nih.gov/index.cfm?objectid=454964FD-F1F6-975E-77716D30B9B3C590
ntp.niehs.nih.gov
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summary
Invirase side effects (Saquinavir Mesylate) and drug interactions - prescription drugs and medications at RxList
... side effects and drug interactions for the drug Invirase (Saquinavir Mesylate) at RxList. ... 2% of patients receiving saquinavir soft gel capsules with ...
http://www.rxlist.com/korean.php?u=http://www.rxlist.com/cgi...
www.rxlist.com
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summary
Fortovase / Invirase (saquinavir)
An easy to understand medication fact sheet for Fortovase and Invirase. ... As of 2006, the formulation of Saquinavir called Fortovase is being phased out ...
http://aids.about.com/od/medicationfactsheets/p/Fortosaquin.htm
aids.about.com
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summary
Safety and Pharmacokinetics of Once-Daily Regimens of Soft-Gel Capsule Saquinavir plus Minidose Ritonavir in Human ...
... plus ritonavir (100 to 200 mg) or a control group receiving only saquinavir-SGC ... curve (AUC) for saquinavir severalfold, and the intersubject peak ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=90...
www.pubmedcentral.nih.gov
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Drugs and Treatments - Saquinavir Oral - Food Interactions from WebMD
Find information about (Saquinavir Oral) on WebMD including drug user ratings, drug interactions, medication warnings, medical uses, side effects and recommended dosage.
http://www.webmd.com/drugs/drug-5031-Saquinavir+Oral.aspx?dr...
www.webmd.com
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summary
Saquinavir; Invirase® ; Ro 31-8959
Saquinavir is active against both HIV-1 and HIV-2 protease with EC50 values in ... P450 (CYP 3A4), the enzyme responsible for saquinavir first pass metabolism (5) ...
http://www.niaid.nih.gov/daids/dtpdb/000640.asp
www.niaid.nih.gov
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summary
Saquinavir Mesylate facts and comparsions at Drugs.com
All about Saquinavir Mesylate. View complete and up to date Saquinavir Mesylate information - part of the Drugs.com trusted medication database.
http://www.drugs.com/cdi/saquinavir-mesylate.html
www.drugs.com
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summary
Saquinavir - Wikipedia
Saquinavir ist ein Arzneistoff aus der Gruppe der Protease-Inhibitoren und wird ... Saquinavir wurde von Roche entwickelt und war 1995 der erste Protease-Inhibitor, ...
http://de.wikipedia.org/wiki/Saquinavir
de.wikipedia.org
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Talk:Saquinavir - Wikipedia, the free encyclopedia
Saquinavir is part of WikiProject Pharmacology, a project to improve all ... Retrieved from "http://en.wikipedia.org/wiki/Talk:Saquinavir" ...
http://en.wikipedia.org/wiki/Talk:Saquinavir
en.wikipedia.org
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New saquinavir 200 and 400 mg tablets.
... forms were studied in comparison to the existed saquinavir 200 mg capsules. ... The quality of saquinavir tablets, in terms of appearance, drug content, ...
http://gateway.nlm.nih.gov/MeetingAbstracts/102283563.html
gateway.nlm.nih.gov
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summary
SAQUINAVIR ORAL (Invirase) side effects, medical uses, and drug interactions.
Read more about the prescription drug SAQUINAVIR ORAL. ... GENERIC NAME: SAQUINAVIR ORAL (sah-KWIN-uh-veer) BRAND NAME(S): Invirase ...
http://www.medicinenet.com/saquinavir_oral/article.htm
www.medicinenet.com
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Saquinavir advanced consumer information | Drugs.com
Saquinavir patient information - advanced edition from the United States Pharmacopoeia. ... Saquinavir will not keep you from spreading HIV to other people. ...
http://www.drugs.com/cons/Saquinavir.html
www.drugs.com
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Saquinavir mesylate
saquinavir levels at least equal to those achieved ... Saquinavir is a structural analogue of the HIV ... Bioavailability of saquinavir mesylate from hard ...
http://aidsinfo.nih.gov/DrugsNew/pdfdrug_tech.asp?int_id=164
aidsinfo.nih.gov
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summary
Pharmacokinetics of saquinavir hard gel/ritonavir (1000/100 mg twice daily) when administered with tenofovir ...
All subjects were receiving ongoing treatment with a saquinavir/ritonavir-containing regimen. ... to the regimen, saquinavir and ritonavir plasma ...
http://www.ncbi.nlm.nih.gov/pubmed/15606438?ordinalpos=100&i...
www.ncbi.nlm.nih.gov
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summary
Clinical Study: 03-CC-0052, Influence of MDR1 Genotype on Indinavir and Saquinavir Pharmacokinetics in Healthy ...
Clinical Study Summary Sheet for 03-CC-0052 ... two protease inhibitors, indinavir and saquinavir, which are used to treat people with HIV. ...
http://clinicalstudies.info.nih.gov/detail/B_2003-CC-0052.html
clinicalstudies.info.nih.gov
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summary
Ritonavir-Saquinavir Dual Protease Inhibitor Compared to Ritonavir Alone in Human Immunodeficiency Virus-Infected ...
... and 234 ± 125/mm3 in the ritonavir and ritonavir-saquinavir groups, respectively. ... pretreated patients, ritonavir-saquinavir has higher antiretroviral efficacy ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=90...
www.pubmedcentral.nih.gov
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Saquinavir
El mesilato de saquinavir fue autorizado por la ... 1995 y el saquinavir, el 7 de noviembre de 1997. ... saquinavir puede causar algunos efectos adversos ...
http://www.aidsinfo.nih.gov/DrugsNew/pdfdrug_sp.asp?int_id=164
www.aidsinfo.nih.gov
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summary
Saquinavir facts and comparsions at Drugs.com
All about Saquinavir. View complete and up to date Saquinavir information - part of the Drugs.com trusted medication database.
http://www.drugs.com/cdi/saquinavir.html
www.drugs.com
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summary
mednet3.who.int
/EML/expcom/expcom12/
saquinavir
.doc
Application for Inclusion of saquinavir/low dose ritonavir (SQV/ r) combination on ... Presently, saquinavir and ritonavir are not available as a fixed dose ...
http://mednet3.who.int/EML/expcom/expcom12/saquinavir.doc
mednet3.who.int
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summary
NTP: IMM98009: Immunotoxicity of Saquinavir in Female B6C3F1 Mice
Saquinavir (SQV) is a protease inhibitor, targeted to interfere late in the ... Saquinavir was nominated to the NTP for toxicological evaluation and was ...
http://ntp-server.niehs.nih.gov/index.cfm?objectid=99AA22E4-...
ntp-server.niehs.nih.gov
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summary
Long term treatment with saquinavir (Invirase), does not lead to a significant reduction in sensitivity to MK-639.
Saquinavir (InviraseTM) is the first inhibitor of HIV proteinase to be ... 83 fold reduction in sensitivity to saquinavir when compared to wild type virus ...
http://gateway.nlm.nih.gov/MeetingAbstracts/102218230.html
gateway.nlm.nih.gov
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summary
Final text for inclusion in The International Pharmacopoeia
Saquinavir mesilate should be kept in a tightly-closed container, protected from ... saquinavir (retention time = about 21 minutes) and the peak of similar size with ...
http://www.who.int/medicines/areas/quality_safety/safety_eff...
www.who.int
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summary
infoSIDA - Medicamentos del VIH/SIDA - Saquinavir
Puesto que la demanda de saquinavir se ha reducido, el fabricante descontinuó ... Si usted toma saquinavir actualmente, pregúntele al médico qué alternativa tiene ...
http://aidsinfo.nih.gov/DrugsNew/DrugDetailSP.aspx?int_id=164
aidsinfo.nih.gov
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summary
Saquinavir patient advice including side effects
Comprehensive and trusted information about Saquinavir - plus advice on 24,000 other FDA approved drugs and medications from Drugs.com.
http://www.drugs.com/pdr/saquinavir.html
www.drugs.com
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summary
SAQUINAVIR - ORAL SOFTGEL CAPSULES (Fortovase) side effects, medical uses, and drug interactions.
Read more about the prescription drug SAQUINAVIR - ORAL SOFTGEL ... of these medications, tell your doctor or pharmacist before starting saquinavir. ...
http://www.medicinenet.com/saquinavir-oral_softgel_capsules/page2.htm
www.medicinenet.com
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summary
Limited-sampling strategy for the prediction of boosted hard-gel saquinavir exposure at a dosage of 1000/100 mg ...
... prediction of boosted hard-gel saquinavir exposure at a dosage of 1000 ... infected individuals stable on saquinavir/ritonavir-containing therapy, randomly ...
http://www.ncbi.nlm.nih.gov/pubmed/17529895?ordinalpos=7&ito...
www.ncbi.nlm.nih.gov
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summary
3rd International Workshop on Clinical Pharmacology of HIV Therapy - Overview
... versus simultaneous administration of nelfinavir, saquinavir, and ritonavir. ... concentration-time curve (AUC) was reduced by 63% compared with saquinavir's AUC ...
http://www.nida.nih.gov/MeetSum/CPHTWorkshop/Flexner.html
www.nida.nih.gov
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AIDSinfo - HIV/AIDS Drug Information - Saquinavir mesylate
Drug Interaction Warning: for Saquinavir/Ritonavir Coadministered with Rifampin ... Sheet on Saquinavir. Clinical Trials Using Saquinavir. Literature Citations ...
http://www.aidsinfo.nih.gov/DrugsNew/DrugDetailM.aspx?MenuIt...
www.aidsinfo.nih.gov
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summary
Drugs and Treatments - Invirase Oral - Patient Handout from WebMD
Find information on WebMD including drug user ratings, drug interactions, ... Saquinavir is known to interact with many different types of medicines, in some ...
http://www.webmd.com/drugs/drug-12027-Invirase+Oral.aspx?dru...
www.webmd.com
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summary
Invirase (saquinavir) medical facts from Drugs.com
Physician reviewed Invirase patient information - includes Invirase description, dosage and directions. ... other medicines that can interact with saquinavir. ...
http://www.drugs.com/mtm/invirase.html
www.drugs.com
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summary
Steady-State Pharmacokinetics of a Double-Boosting Regimen of Saquinavir Soft Gel plus Lopinavir plus Minidose ...
... (25 given ritonavir, lopinavir, and saquinavir and 15 given ritonavir and lopinavir) ... were similar in patients with and without saquinavir. ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=525389
www.pubmedcentral.nih.gov
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Protease Inhibitors
(R)2QuinCOAsnPhe [CHOHCH2]PipCONHtBu; Saquinavir deriv. ... LY314163; Saquinavir/Nelfinavir deriv. ... Saquinavir; Invirase® ; Ro 31-8959; Fortovase® Approved ...
http://www.niaid.nih.gov/daids/dtpdb/protinh1.htm
www.niaid.nih.gov
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