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what is 'l-asparaginase'? Definition for L-asparaginase Asparaginase ( EC 3.5.1.1 ) is an enzyme that catalyzes the hydrolysis of asparagine to aspartic acid . It is marketed under the brand name Elspar , to treat acute lymphoblastic leukemia (ALL) and is also used in some mast cell tumor protocols. more Asparaginase ( EC 3.5.1.1 ) is an enzyme that catalyzes the hydrolysis of asparagine to aspartic acid . It is marketed under the brand name Elspar , to treat acute lymphoblastic leukemia (ALL) and is also used in some mast cell tumor protocols. [ 1 ] Unlike other chemotherapy agents, it can be given as an intramuscular, subcutaneous, or intravenous injection without fear of tissue irritation. less diagnoses treated with 'l-asparaginase' 1 - 2 of 2 diagnosis metastases spread of malignant tumors to other body sites web search for: L-asparaginase and metastases malignancy cancer web search for: L-asparaginase and malignancy related procedures when taking 'l-asparaginase' 1 - 5 of 148 procedures Abdominal CAT Scan web search for: L-asparaginase and Abdominal CAT Scan Abdominal MRI MRI of abdominal contents web search for: L-asparaginase and Abdominal MRI Array genomic hybridization web search for: L-asparaginase and Array genomic hybridization BUN web search for: L-asparaginase and BUN Bacille Calmette-Guérin (BCG) web search for: L-asparaginase and Bacille Calmette-Guérin (BCG) Beta-2 microglobulin web search for: L-asparaginase and Beta-2 microglobulin Biopsy web search for: L-asparaginase and Biopsy Biopsy skin web search for: L-asparaginase and Biopsy skin Bladder tumor antigen (BTA) web search for: L-asparaginase and Bladder tumor antigen (BTA) Brachytherapy Sealed source radiotherapy web search for: L-asparaginase and Brachytherapy Brain MRI web search for: L-asparaginase and Brain MRI Breast Self Exams web search for: L-asparaginase and Breast Self Exams Brush Cytology web search for: L-asparaginase and Brush Cytology CA 125 (cancer antigen 125) web search for: L-asparaginase and CA 125 (cancer antigen 125) CA 15-3 (cancer antigen 15.3) web search for: L-asparaginase and CA 15-3 (cancer antigen 15.3) CA 19-9 (cancer antigen 19-9) web search for: L-asparaginase and CA 19-9 (cancer antigen 19-9) CA 27.29 ((cancer antigen 27.29) web search for: L-asparaginase and CA 27.29 ((cancer antigen 27.29) CA 72-4 (cancer antigen 72-4) web search for: L-asparaginase and CA 72-4 (cancer antigen 72-4) CT Guided Needle Biopsy web search for: L-asparaginase and CT Guided Needle Biopsy CT Pelvis web search for: L-asparaginase and CT Pelvis for more please login, login is free (click to login) related medication for 'l-asparaginase' 1 - 5 of 82 drugs 5-fluorouracil (5-fu) web search for: L-asparaginase and 5-fluorouracil (5-fu) 6-mercaptopurine (6-mp) web search for: L-asparaginase and 6-mercaptopurine (6-mp) actinomycin-d web search for: L-asparaginase and actinomycin-d alemtuzumab web search for: L-asparaginase and alemtuzumab alkylating agents web search for: L-asparaginase and alkylating agents altretamine web search for: L-asparaginase and altretamine anastrozole web search for: L-asparaginase and anastrozole anti tumor antibiotics web search for: L-asparaginase and anti tumor antibiotics antimetabolites web search for: L-asparaginase and antimetabolites arsenic trioxide web search for: L-asparaginase and arsenic trioxide bevacizumab web search for: L-asparaginase and bevacizumab bexarotene web search for: L-asparaginase and bexarotene bicalutamide web search for: L-asparaginase and bicalutamide bleomycin web search for: L-asparaginase and bleomycin bortezomib web search for: L-asparaginase and bortezomib busulfan web search for: L-asparaginase and busulfan capecitabine web search for: L-asparaginase and capecitabine carmustine (bcnu) web search for: L-asparaginase and carmustine (bcnu) cetuximab web search for: L-asparaginase and cetuximab chlorambucil web search for: L-asparaginase and chlorambucil for more please login, login is free (click to login) The following are types of physicians relevant for 'L-asparaginase'. related types of physicians 'family practitioner, internist, oncologist' show local physicians postal code Find Local stars represent relevance to topic not rating more The results are computer generated suggestions to help you find a physician. MEDgle does not recommend any particular type of physician or claim to be complete or accurate in the providers and specialties suggested. web search results for 'l-asparaginase'? Results 1 - 50 - L-asparaginase Asparaginase - Wikipedia, the free encyclopedia From Wikipedia, the free encyclopedia (Redirected from L-asparaginase) ... It is marketed under the brand name Elspar, to treat acute lymphoblastic ... http://en.wikipedia.org/wiki/L-asparaginase   en.wikipedia.org - summary l-Asparaginase from Proteus vulgaris Antilymphoma activity of L-asparaginase in vivo: clearance rates of enzyme ... WRISTON JC Jr. TUMOR INHIBITORY EFFECT OF L-ASPARAGINASE FROM ESCHERICHIA COLI. ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=376319   www.pubmedcentral.nih.gov - summary Oncaspar L-asparaginase is modified by covalently conjugating units of ... The L-asparaginase used in the manufacture of pegaspargase is derived from ... http://www.drugs.com/mmx/oncaspar.html?printable=1   www.drugs.com - summary Childhood Acute Lymphoblastic Leukemia Induction Chemotherapy Three-drug induction therapy using vincristine,prednisone/dexamethasone,plus L-asparaginase in conjunction with intrathecal therapy (IT) ... http://www.webmd.com/cancer/tc/leukemia-acute-lymphoblastic-...   www.webmd.com - summary Childhood Acute Lymphoblastic Leukemia Treatment - National Cancer ... Expert-reviewed information summary about the treatment of childhood acute ... Several forms of L-asparaginase are available for use in the treatment of ... http://www.nci.nih.gov/cancertopics/pdq/treatment/childALL/H...   www.nci.nih.gov - summary L-asparaginase / L-asparagine amidohydrolase, Arabidopsis thaliana ... A summary of the mRNA sequence representatives for a transcribed locus ... L-asparaginase / L-asparagine amidohydrolase (AT5G08100) SELECTED PROTEIN SIMILARITIES ... http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=5449   www.ncbi.nlm.nih.gov - summary Immunological responses to l-asparaginase L-asparaginase: therapeutic and toxic effects in patients with neoplastic disease. ... E. coli L-asparaginase in the treatment of leukemia and solid tumors in ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=292030   www.pubmedcentral.nih.gov - summary L-asparaginase, Glycine max - UniGene Gma.16856 A summary of the mRNA sequence representatives for a transcribed locus ... L-asparaginase (LOC547703) SELECTED PROTEIN SIMILARITIES ... http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Gma&CID=16856   www.ncbi.nlm.nih.gov - summary l-Asparaginase-Induced Antithrombin Type I Deficiency Interestingly, l-asparaginase treatment of acute lymphoblastic leukemia patients ... l-Asparaginase did not affect functional or conformational parameters of mature ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1698772   www.pubmedcentral.nih.gov - summary Definition of L-asparaginase - NCI Dictionary of Cancer Terms Virtual and Standard Colonoscopy Both Accurate. NCI Responds to Hurricanes. The Nation's Investment in Cancer ... L-asparaginase (... as-PA-ruh-jih-nayz) ... http://www.nci.nih.gov/Templates/db_alpha.aspx?CdrID=601030   www.nci.nih.gov - summary Aspartylglucosaminidase - Wikipedia, the free encyclopedia Aspartylglucosaminidase. From Wikipedia, the free ... N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity. ? hydrolase activity. Cellular component: ... http://en.wikipedia.org/wiki/Aspartylglucosaminidase   en.wikipedia.org - summary L-Asparaginase in Treatment of Acute Leukaemia and Lymphosarcoma L-Asparaginase was used to treat 40 patients with acute leukaemia or lymphosarcoma. ... patients with lymphosarcoma received L-asparaginase, two of them having ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1699280   www.pubmedcentral.nih.gov - summary L-asparaginase, putative / L-asparagine amidohydrolase, putative ... A summary of the mRNA sequence representatives for a transcribed locus ... Arabidopsis thaliana L-asparaginase, putative / L-asparagine amidohydrolase, ... http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=38938   www.ncbi.nlm.nih.gov - summary L-asparaginase (-log MOLT-4. CCRF-CEM. HL-60(TB) RPMI- 8226. SR. K562. less sensitive. more ... L-asparaginase (-log. 10. GI. 50. asparagine synthetase expression eevel (log. 2 ... http://discover.nci.nih.gov/nature2000/paper/fig5.pdf   discover.nci.nih.gov - summary Oncaspar side effects (Pegaspargase) and drug interactions ... Learn the potential medication side effects and drug interactions for the ... Unfavorable interactions of L-asparaginase with some antitumor agents have been ... http://www.rxlist.com/cgi/generic/pegaspargase_ad.htm   www.rxlist.com - summary Definition of pegaspargase - National Cancer Institute Drug Dictionary A complex of polyethylene glycol conjugated with L-asparaginase. ... (monomethoxypolyethylene glycol succinimidyl)74-L-asparaginase. Previous: ... http://www.nci.nih.gov/Templates/drugdictionary.aspx?CdrID=40312   www.nci.nih.gov - summary Purification and Properties of l-Asparaginase from Serratia marcescens Evidence that the L-asparaginase of guinea pig serum is responsible for its ... WRISTON JC Jr. TUMOR INHIBITORY EFFECT OF L-ASPARAGINASE FROM ESCHERICHIA COLI. ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=285133   www.pubmedcentral.nih.gov - summary Elspar Official FDA information, side effects and uses. Accurate, FDA approved Elspar information for healthcare professionals and patients - brought to you ... Serious thrombosis with prior L-asparaginase therapy ... http://www.drugs.com/pro/elspar.html   www.drugs.com - summary asp - PubChem Public Chemical Database PubChem Compound Summary ... L-Asparaginase Of E. Coli In C2 Space Group And 1.95 A Resolution. Hydrolase ... Mol_id: 1; Molecule: L-Asparaginase Ii; Chain: A, ... http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=827788   pubchem.ncbi.nlm.nih.gov - summary Structure of the type I L-asparaginase from the hy...[Acta Crystallogr ... PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE and other life science journals for biomedical ... http://www.ncbi.nlm.nih.gov/pubmed/15735339   www.ncbi.nlm.nih.gov - summary NIH Office of Technology Transfer (OTT) >> Abstract Search The NIH Office of Technology Transfer (OTT) evaluates, protects, monitors, and manages the NIH invention portfolio ... decades, L-asparaginase (L-ASP) has ... http://ott.od.nih.gov/db/abstxt.asp?refno=1489   ott.od.nih.gov - summary L-Asparaginase Production by Erwinia aroideae Only one L-asparaginase was present as determined by electrophoresis, and the ... Evidence that the L-asparaginase of guinea pig serum is responsible for its ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=377887   www.pubmedcentral.nih.gov - summary Structure and expression in Escherichia coli K-12 ...[Gene. 1989 ... PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from ... L-asparaginase II of Escherichia coli K-12: ... http://www.ncbi.nlm.nih.gov/pubmed/2670682   www.ncbi.nlm.nih.gov - summary Elspar Serious thrombosis with prior L-asparaginase therapy ... Serious hemorrhagic events with prior L-asparaginase therapy. 5 WARNINGS AND PRECAUTIONS ... http://www.drugs.com/pro/elspar.html?printable=1   www.drugs.com - summary Effects on specific antibodies on the catalytic activity of ... Continuous assays of L-asparaginase by coupling with glutamic dehydrogenase and ... Crystalline L-asparaginase from Escherichia coli B. I. Purification and chemical ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=235911   www.pubmedcentral.nih.gov - summary Asparagine synthetase as a causal, predictive biomarker for ... ... predictive biomarker for L-asparaginase activity in ovarian cancer ... L-Asparaginase (L-ASP), a bacterial enzyme used since the 1970s to treat acute ... http://discover.nci.nih.gov/host/2006_asparagine_abstract.jsp   discover.nci.nih.gov - summary Pegaspargase: a review of clinical studies. [Adv Drug Deliv Rev. 2003 ... PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE ... evaluation of L-asparaginase in the ... http://www.ncbi.nlm.nih.gov/pubmed/14499708   www.ncbi.nlm.nih.gov - summary L-Asparaginase Production by Streptomyces griseus L-Asparaginase Production by Streptomyces griseus. Peter J. DeJong ... 10137 synthesizes about 1 IU of L-asparaginase/100 ml of a 4% peptone medium. ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=4626231   www.pubmedcentral.nih.gov - summary Glutamate Oxidation in 6C3HED Lymphoma: Effects of L-Asparaginase on ... Evidence that the L-asparaginase of guinea pig serum is responsible for its ... Studies on the mechanism of tumor inhibition by L-asparaginase. ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?&artid=434313   www.pubmedcentral.nih.gov - summary Hyperglycemia, ketoacidosis and other complication...[J Med. 1994 ... PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE and ... reactions to L-asparaginase do not ... http://www.ncbi.nlm.nih.gov/pubmed/7996065   www.ncbi.nlm.nih.gov - summary Effect of culture conditions on synthesis of L-asparaginase by ... L-asparaginase production during static incubation of aerobically grown ... O, Strbánová-Necinová S. Induction of L-asparaginase synthesis in Escherichia coli. ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=170675   www.pubmedcentral.nih.gov - summary Crystal packing of plant-type L-asparaginase from Escherichia coli. Plant-type L-asparaginases hydrolyze the side-chain amide bond of L-asparagine ... They belong to the N-terminal nucleophile (Ntn) hydrolases and are synthesized ... http://www.ncbi.nlm.nih.gov/pubmed/18323626?ordinalpos=2&ito...   www.ncbi.nlm.nih.gov - summary Fermentation Kinetics and Continuous Process of L-Asparaginase Production For the purpose of obtaining L-asparaginase in quantities from Erwinia aroideae, ... JC Jr. TUMOR INHIBITORY EFFECT OF L-ASPARAGINASE FROM ESCHERICHIA COLI. ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?&artid=380741   www.pubmedcentral.nih.gov - summary Pegaspargase ... results from treatment with the enzyme L-asparaginase, kills the leukemic cells. ... native form of L-asparaginase; combination therapy of multiagent chemotherapy ... http://www.drugs.com/ppa/pegaspargase.html?printable=1   www.drugs.com - summary Factors Influencing L-Asparaginase Production by Erwinia aroideae Increased yields of L-asparaginase from Erwinia aroideae NRRL B-138 were ... Conditions for the Production of L-Asparaginase 2 by Coliform Bacteria. Appl Microbiol. ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=380410   www.pubmedcentral.nih.gov - summary Structure Summary, 1HFW, 17186 MMDB is a database of three-dimensional biomolecular structure ... X-Ray Structure Of The Complex Between Erwinia Chrysanthemi L-Asparaginase And L-Glutamate. ... http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?uid=17186   www.ncbi.nlm.nih.gov - summary NCI Funded Research Portfolio - Z01 BC 010823 Abstract Asparagine Synthetase as a Biomarker for L-asparaginase Rx of Ovarian Cancer. The bacterial enzyme L-asparaginase (L-ASP) was approved by the FDA in 1979 for ... http://deais.nci.nih.gov/Query/search/details?action=abstrac...   deais.nci.nih.gov - summary Effect of Glucose and Low Oxygen Tension on l-Asparaginase Production ... Cultural and nutritional requirements for maximum l-asparaginase synthesis were determined. ... Antilymphoma activity of L-asparaginase in vivo: clearance ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=377091   www.pubmedcentral.nih.gov - summary Structure Summary, 1HO3, 15557 MMDB is a database of three-dimensional biomolecular structure at the ... Periplasmic Escherichia coli L-asparaginase II with Y25F mutation in the active ... http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?uid=15557   www.ncbi.nlm.nih.gov - summary l-Glutamine as a Substrate for l-Asparaginase from Serratia marcescens Evidence that the L-asparaginase of guinea pig serum is responsible for its ... Sano R, Yamamoto K, Nakamura M, Chibata I. L-asparaginase from Proteus vulgaris. ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=285550   www.pubmedcentral.nih.gov - summary Complete Pegaspargase information from Drugs.com All about Pegaspargase. View complete and up to date Pegaspargase ... results from treatment with the enzyme L-asparaginase, kills the leukemic cells. ... http://www.drugs.com/ppa/pegaspargase.html   www.drugs.com - summary Genetic and physiological relationships between L-asparaginase I and ... The cistron that codes for L-asparaginase I in Saccharomyces cerevisiae (aspl) ... Cells lacking L-asparaginase I but possessing asparaginase II grow more rapidly ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=235182   www.pubmedcentral.nih.gov - summary Crystal structure of Escherichia coli L-asparaginase, an enzyme used in ... L-asparaginase for treatment of lymphoid neoplasia in dogs. J Am Vet ... l-asparaginase resistance in human leukemia--asparagine synthetase. Biochem Pharmacol. ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=45896   www.pubmedcentral.nih.gov - summary Integrating data on DNA copy number with gene expression levels and ... ... between activity of the enzyme drug l-asparaginase and DNA copy number of genes ... strongly suggests further study of l-asparaginase for possible treatment of a ... http://discover.nci.nih.gov/host/2006_integrating_abstract.jsp   discover.nci.nih.gov - summary L-Asparaginase Production by the Rumen Anaerobe Vibrio succinogenes The rumen anaerobe Vibrio succinogenes possesses a constitutive L-asparaginase. ... R, Yamamoto K, Nakamura M, Chibata I. L-asparaginase from Proteus vulgaris. ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=379995   www.pubmedcentral.nih.gov - summary L-Asparaginase Synthesis by Erwinia aroideae Maximum L-asparaginase activity was obtained when 1.0% lactose and 1.5% yeast ... Peterson RE, Ciegler A. L-Asparaginase Production by Erwinia aroideae. Appl ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=380408   www.pubmedcentral.nih.gov - summary Oncaspar Information for Oncaspar on Drugs.com. May include images, interactions and ... Oncaspar® (pegaspargase) is a modified version of the enzyme L-asparaginase. ... http://www.drugs.com/search.php?searchterm=Oncaspar   www.drugs.com - summary EVIDENCE THAT THE L-ASPARAGINASE OF GUINEA PIG SERUM IS RESPONSIBLE FOR ... I. PROPERTIES OF THE L-ASPARAGINASE OF GUINEA PIG SERUM IN RELATION TO THOSE OF ... L-Asparaginase activity was essentially absent from the serum of newborn guinea ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2137570   www.pubmedcentral.nih.gov - summary www.ncbi.nlm.nih.gov/COG/old/coogtik.cgi?COG0252 [EJ] COG0252 L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D. 6 ... [GEPR] COG0477 Permeases of the major facilitator superfamily. 3 ... http://www.ncbi.nlm.nih.gov/COG/old/coogtik.cgi?COG0252   www.ncbi.nlm.nih.gov - summary Multiple adaptive mechanisms affect asparagine synthetase substrate ... L-asparaginase therapy in children with advanced leukemia. ... Methotrexate plus L-asparaginase. ... Studies on the mechanism of tumor inhibition by L-asparaginase. ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1222032   www.pubmedcentral.nih.gov - summary show more 1  2

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