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aprotinin
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what is 'aprotinin'?
Definition for Aprotinin - Aprotinin
Aprotinin , also known as bovine pancreatic trypsin inhibitor, BPTI (Trasylol, Bayer ) is a protein, that is used as medication administered by injection to reduce bleeding during complex surgery , such as heart and liver surgery.
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Aprotinin , also known as bovine pancreatic trypsin inhibitor, BPTI (Trasylol, Bayer ) is a protein, that is used as medication administered by injection to reduce bleeding during complex surgery , such as heart and liver surgery. Its main effect is the slowing down of fibrinolysis , the process that leads to the breakdown of blood clots. The aim in its use is to decrease the need for blood transfusions during surgery, as well as end-organ damage due to hypotension (low blood pressure) as a result of marked blood loss. The drug was temporarily withdrawn worldwide in 2007 after studies suggested that its use increased the risk of complications or death [ 1 ] ; after this was confirmed by follow-up studies, Trasylol was entirely and permanently withdrawn in May 2008, except - at least for the time being - for very restricted research use.
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web search results for 'aprotinin'?
Results
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- Aprotinin
Aprotinin - Wikipedia, the free encyclopedia
Aprotinin, also known as bovine pancreatic trypsin inhibitor, BPTI (Trasylol® ... Aprotinin inhibits several serine proteases, specifically trypsin, chymotrypsin ...
http://en.wikipedia.org/wiki/Aprotinin
en.wikipedia.org
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Trasylol (Aprotinin) drug description - prescription drugs and medications at RxList
Find Trasylol (Aprotinin) medication description and details on prescription drugs. ... upon re-exposure within 12 months of the most recent prior aprotinin exposure. ...
http://www.rxlist.com/cgi/generic/aprotin.htm
www.rxlist.com
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Drugs and Treatments - Aprotinin (Bovine) IV - Patient Handout from WebMD
Information on Aprotinin (Bovine) IV - Patient Handout. Find the answers you need about over the counter and prescription medications, vitamins and supplements, and ...
http://www.webmd.com/drugs/drug-9996-Aprotinin+Bovine+IV.asp...
www.webmd.com
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Aprotinin - Wikipedia
... dem Ergebnis gekommen, dass Aprotinin ein sicheres und effektives ... Observational Studies of Drug Safety - Aprotinin and the Absence of Transparency, ...
http://de.wikipedia.org/wiki/Aprotinin
de.wikipedia.org
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Aprotinin Drug Interactions - Drugs.com
Aprotinin Drug Interactions. Drug-drug and drug-food interactions for Aprotinin ... below to view Drug-Drug Interactions with aprotinin. Back. All Services ...
http://www.drugs.com/drug-interactions/aprotinin_d03185.html
www.drugs.com
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Aprotinin (Intravenous Route) - MayoClinic.com
Mayo Clinic offers award-winning medical and health information and tools for healthy living. ... Aprotinin is used to prevent blood loss and reduce the need ...
http://www.mayoclinic.com/health/drug-information/DR602397
www.mayoclinic.com
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Use of aprotinin to reduce intraoperative bleeding.
Effect of aprotinin on need for blood transfusion after repeat open-heart surgery. ... use after cardiopulmonary bypass with high dose aprotinin (Trasylol) ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1022232
www.pubmedcentral.nih.gov
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FDA to Trasylol After Trial Suggests Death Risk - Health and Medical Information Produced by Doctors - MedicineNet...
Read doctor-produced health and medical information written for you to make ... safety of the clotting drug aprotinin (Trasylol), after a major Canadian trial ...
http://www.medicinenet.com/script/main/art.asp?articlekey=84799
www.medicinenet.com
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Definition of aprotinin bovine - National Cancer Institute Drug Dictionary
Report Finds Cancer Death Rate Decline Doubling ... serine protease inhibitor, aprotinin bovine competitively and reversibly ...
http://www.nci.nih.gov/Templates/drugdictionary.aspx?CdrID=480388
www.nci.nih.gov
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Using a bibliometric analysis of the literature to understand the diffusion of two pharmacological agents to ...
Aprotinin effectively reduces perioperative blood loss and exposure to ... 1995 identified 1151 documents relating to aprotinin and 815 relating to DDAVP. ...
http://gateway.nlm.nih.gov/MeetingAbstracts/102233229.html
gateway.nlm.nih.gov
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Talk:Aprotinin - Wikipedia, the free encyclopedia
Aprotinin is within the scope of WikiProject Chemicals, a daughter project of ... "Aprotinin doubles a patient's risk of kidney failure, heart failure, and heart ...
http://en.wikipedia.org/wiki/Talk:Aprotinin
en.wikipedia.org
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eMedicine Online Medical Textbooks by Specialty: Free Journal Articles and Texts for Physicians and Health ...
eMedicine features up-to-date, searchable, peer-reviewed medical journals, ... Additionally, after receiving aprotinin, readministration is contraindicated for ...
http://www.emedicine.com/recalls-alerts.asp?year=2006
www.emedicine.com
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aprotinin
Prev Term: apraxia. Next Term: aptamer. aprotinin. Used for: ... single-chain polypeptide inhibitor of proteolytic enzymes including chymotrypsin, ...
http://crisp.cit.nih.gov/Thesaurus/00000569.htm
crisp.cit.nih.gov
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Drugs and Treatments - Aprotinin (Bovine) IV - Side Effects from WebMD
Information on Aprotinin (Bovine) IV - Side Effects. Find the answers you need about over the counter and prescription medications, vitamins and supplements, and ...
http://www.webmd.com/drugs/drug-9996-Aprotinin+(Bovine)+Intr...
www.webmd.com
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WHO Drug Information
Aprotinin is indicated for prophylactic. use to reduce perioperative blood loss ... previous aprotinin exposure during the. last 12 months is contraindicated. ...
http://www.who.int/druginformation/vol21num2_2007/DI21-2.pdf
www.who.int
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Trasylol Official FDA information, side effects and uses.
Accurate, FDA approved Trasylol information for healthcare professionals and ... upon re-exposure within 12 months of the most recent prior aprotinin exposure. ...
http://www.drugs.com/pro/trasylol.html
www.drugs.com
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Microsoft Word - West Blot-Protein Prep
Aprotinin. Sigma, Cat. A1153. EDTA 0.5 M. Quality Biological, Inc., Cat. 351-027-100 ... Aprotinin. 1:1000. Leupeptin. 1:1000. PMSF. 1:10. Procedure. 1. ...
http://www.riedlab.nci.nih.gov/publications/West%20Blot-Protein%20Prep.pdf
www.riedlab.nci.nih.gov
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FDA Issues Early Communication About an Ongoing Safety Review of Aprotinin Injection on Rxlist
Read about FDA's issue of early communication about an ongoing safety review of Aprotinin Injection, a drug used to control bleeding during heart surgery on RxList.
http://www.rxlist.com/script/main/art.asp?articlekey=84849
www.rxlist.com
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Effect of aprotinin on the renal response to vasopressin in diabetes insipidus rats.
... of the kallikrein inhibitor, aprotinin, in conscious Brattleboro homozygous rats ... However, aprotinin failed to modify the arginine vasopressin-induced ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1199180
www.pubmedcentral.nih.gov
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Drugs and Treatments - Aprotinin (Bovine) IV - Conditions from WebMD
Information on Aprotinin (Bovine) IV - Conditions. Find the answers you need about over the counter and prescription medications, vitamins and supplements, and much ...
http://www.webmd.com/drugs/drug-9996-Aprotinin+(Bovine)+Intr...
www.webmd.com
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FDA Alert: Aprotinin Injection (marketed as Trasylol)
... to stop patient enrollment in the aprotinin treatment group arm of the Blood ... to test the hypothesis that aprotinin was superior to epsilon-aminocaproic acid ...
http://www.drugs.com/fda/aprotinin-marketed-trasylol-12212.html
www.drugs.com
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Alternative technologies to allogeneic blood transfusion - diffusion and attitudes in Denmark.
... have assessed 4 drugs (aprotinin, desmopressin, tranexamic acid, erythropoietin) ... used, while erythropoietin, aprotinin, and especially desmopressin are ...
http://gateway.nlm.nih.gov/MeetingAbstracts/102234705.html
gateway.nlm.nih.gov
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Intraoperative antifibrinolysis and blood-saving techniques in cardiac surgery. Prospective trial of 3 ...
... and blood use after cardiopulmonary bypass with high dose aprotinin (Trasylol) ... Aprotinin reduces intraoperative and postoperative blood loss in membrane ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=7580360
www.pubmedcentral.nih.gov
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Drugs and Treatments - Aprotinin (Bovine) IV - Warnings from WebMD
Information on Aprotinin (Bovine) IV - Warnings. Find the answers you need about over the counter and prescription medications, vitamins and supplements, and much more.
http://www.webmd.com/drugs/drug-9996-Aprotinin+(Bovine)+IV.a...
www.webmd.com
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Modulation of the Alignment Tensor of Macromolecules Dissolved in a Dilute Liquid Crystalline Medium
For aprotinin, addition of positive charge to the bicelles ... were unable to check whether the aprotinin alignment increases ...
http://spin.niddk.nih.gov/bax/lit/pdf/267.pdf
spin.niddk.nih.gov
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Microsoft Word - 2D Gel Protein Ext
Aprotinin. Sigma, Cat. A1153. Benzamidine. Sigma, Cat. B6508. Hepes, pH 8. Isopropanol (2-Propanol) ... Aprotinin. 1:1000. Leupeptin. 1:1000. PMSF. 1:50 ...
http://www.riedlab.nci.nih.gov/publications/2D%20Gel%20Protein%20Ext.pdf
www.riedlab.nci.nih.gov
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User talk:Jfdwolff/Archive 21 - Wikipedia, the free encyclopedia
59 Aprotinin. 60 You're ignorant about Parkinson's Disease. 61 Your edit on my talk page ... poorly structured sentence, in your discussion of Aprotinin. ...
http://en.wikipedia.org/wiki/User_talk:Jfdwolff/Archive_21
en.wikipedia.org
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A disheartening story: Aprotinin in cardiac surgery
A disheartening story: Aprotinin in cardiac surgery. Marcus Lien1 and Eric B Milbrandt2. 1Clinical Fellow, Department of Critical Care Medicine, University of ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1794445
www.pubmedcentral.nih.gov
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Drugs and Treatments - Aprotinin (Bovine) IV - Drug Images from WebMD
Information on Aprotinin (Bovine) IV - Drug Images. Find the answers you need about over the counter and prescription medications, vitamins and supplements, and much ...
http://www.webmd.com/drugs/drug-9996-Aprotinin+(Bovine)+Intr...
www.webmd.com
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Trasylol Pulled From Worldwide Market - Heart Disease and Other Cardiovascular Conditions on MedicineNet.com
Information on heart disease and related cardiovascular conditions includes medications, procedures ... "the death rate for aprotinin patients far outstrips that ...
http://www.medicinenet.com/script/main/art.asp?articlekey=85003
www.medicinenet.com
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Aprotinin facts and comparsions at Drugs.com
All about Aprotinin. View complete and up to date Aprotinin information - part of the Drugs.com trusted medication database.
http://www.drugs.com/pdr/aprotinin.html
www.drugs.com
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Bypass Drug Linked to Increased Deaths
A new study questions the continued use of the drug aprotinin, commonly used to limit blood loss during some types of cardiac surgery, due to safety concerns.
http://www.webmd.com/content/article/131/118157.htm?ecd=wnl_day_020707
www.webmd.com
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Antifibrinolytic therapy in cardiac surgery.
... haemodynamic effects of high-dose aprotinin in a paediatric cardiac surgical patient. ... Aprotinin protects platelets against the initial effect of ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=7580358
www.pubmedcentral.nih.gov
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Blast Result
... Of The Mtsp1 (Matriptase)-Bpti (Aprotinin) Complex >gi|18655572|pdb|1EAW|C Chain C, Crystal Structure Of The Mtsp1 (Matriptase)-Bpti (Aprotinin) Complex > ...
http://www.ncbi.nlm.nih.gov/blast/bl2seq/wblast2.cgi?prot=bl...
www.ncbi.nlm.nih.gov
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Mequinol and Tretinoin (Topical Route) - MayoClinic.com
Mayo Clinic offers award-winning medical and health information and tools for healthy living. ... Aprotinin. Tetracycline. Tranexamic Acid. Other Interactions ...
http://www.mayoclinic.com/health/drug-information/DR600217
www.mayoclinic.com
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Antifibrinolytic - Wikipedia, the free encyclopedia
Antifibrinolytics, such as aminocaproic acid (?-aminocaproic ... Aminomethylbenzoic acid) - serpins (Aprotinin, Alfa1 antitrypsin, C1-inhibitor, Camostat) ...
http://en.wikipedia.org/wiki/Antifibrinolytic
en.wikipedia.org
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eMedicine - Alpha2-Plasmin Inhibitor Deficiency : Article by Olga Kozyreva
Platelet disorders and inherited or acquired deficiencies of hemostatic factors ... Aprotinin treatment effectively suppressed hyperfibrinolysis and reduced ...
http://www.emedicine.com/med/topic109.htm
www.emedicine.com
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Ap - Ar index - Drugs.com
Aprotinin. Aptivus. Aptivus. Aptivus. Aqua Care Cream. Aquachloral Supprettes Suppositories ... Result Page: Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 ...
http://www.drugs.com/alpha/a21.html
www.drugs.com
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FDA Newsroom Article Index on RxList
Find FDA updates and news releases on prescription ... Aprotinin Injection: Ongoing Safety Review. Ixempra for Advanced Breast Cancer Patients Approved ...
http://www.rxlist.com/script/main/art.asp?articlekey=80888
www.rxlist.com
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Identification of the second cluster of ligand-binding repeats in megalin as a site for receptor?ligand interactions
... (?VLDL), lipoprotein lipase, aprotinin, lactoferrin, and the receptor-associated ... activator inhibitor (12, 15?18), aprotinin (16), polybasic drugs such as ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=9122201
www.pubmedcentral.nih.gov
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MedlinePlus: FDA to Review Clotting Drug After Trial Suggests Death Risk
FDA to Review Clotting Drug After Trial Suggests Death Risk ... safety of the clotting drug aprotinin (Trasylol), after a major Canadian trial ...
http://www.nlm.nih.gov/medlineplus/news/fullstory_56690.html
www.nlm.nih.gov
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Trypsin inhibitor - Wikipedia, the free encyclopedia
Trypsin inhibitors are chemicals that reduce the bio-availability of ... When extracted from lung tissue, this is known as aprotinin. Ovomucoid. 8-10 kDa ...
http://en.wikipedia.org/wiki/Trypsin_inhibitor
en.wikipedia.org
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FDA Alerts
FDA Alerts from Drugs.com. Comprehensive and up-to-date drug news for ... a marketing suspension of Trasylol (aprotinin injection), a drug used to control...
http://www.drugs.com/fda_alerts.html
www.drugs.com
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Drugs A-Z List of Brand and Generic Medications at RxList
Browse an A-Z list of Brand and Generic drugs to learn about your prescription ... Aprotinin Injection: FDA Safety Review. Ixempra for Advanced Breast Cancer ...
http://www.rxlist.com/script/main/art.asp?articlekey=79437
www.rxlist.com
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ATC code B02 - Wikipedia, the free encyclopedia
A section of the Anatomical Therapeutic Chemical Classification System. ... B02AB01 Aprotinin. B02AB02 Alfa1 antitrypsin. B02AB03 C1-inhibitor. B02AB04 Camostat ...
http://en.wikipedia.org/wiki/ATC_code_B02
en.wikipedia.org
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Evidence-Based Treatment of Acute Pancreatitis
... and the value of aprotinin, lexipafant, gabexate mesylate, and octreotide treatment. ... randomized, one compared gabexate with aprotinin, and one study was only ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1448904
www.pubmedcentral.nih.gov
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UROKINASE - INJECTION (Abbokinase) side effects, medical uses, and drug interactions.
Consumer information about the medication UROKINASE - INJECTION (Abbokinase) ... effects of urokinase include: aminocaproic acid, aprotinin, tranexamic acid. ...
http://www.medicinenet.com/urokinase-injection/page2.htm
www.medicinenet.com
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No
Aprotinin -- Reports of serious cardiovascular, cerebrovascular and kidney effects . have linked aprotinin (Trasylol) injection with an increased risk ...
http://www.who.int/entity/medicines/publications/2006News2%20.pdf
www.who.int
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Miles Laboratories - Wikipedia, the free encyclopedia
Miles also published Medical News, a thinly disguised marketing vehicle for Nervine. Nervine remained on the market as a "calmative" until the late 1960s. ...
http://en.wikipedia.org/wiki/Miles_Laboratories
en.wikipedia.org
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Delayed Mortality and Attenuated Thrombocytopenia Associated with Severe Malaria in Urokinase- and Urokinase ...
Administration of aprotinin, a plasmin antagonist, also delayed mortality and ... well as the treatment with aprotinin, might modify several systems implicated in ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?&artid=101654
www.pubmedcentral.nih.gov
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