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6-mercaptopurine (6-mp)
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what is '6-mercaptopurine (6-mp)'?
Definition for 6-mercaptopurine (6-mp)
Mercaptopurine (also called 6-Mercaptopurine, 6-MP or its brand name Purinethol ) is an immunosuppressive drug .
It is a thiopurine . [ 1 ]
It is used to treat leukemia . It is also used for pediatric non-Hodgkin's lymphoma , [ citation needed ] polycythemia vera , [ citation needed ] psoriatic arthritis , [ citation needed ] and inflammatory bowel disease (such as Crohn's Disease and ulcerative colitis ). [ 2 ]
diagnoses treated with '6-mercaptopurine (6-mp)'
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diagnosis
metastases
spread of malignant tumors to other body sites
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6-mercaptopurine (6-mp) and metastases
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6-mercaptopurine (6-mp) and malignancy
related procedures when taking '6-mercaptopurine (6-mp)'
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148
procedures
Abdominal CAT Scan
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6-mercaptopurine (6-mp) and Abdominal CAT Scan
Abdominal MRI
MRI of abdominal contents
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6-mercaptopurine (6-mp) and Abdominal MRI
Array genomic hybridization
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6-mercaptopurine (6-mp) and Array genomic hybridization
BUN
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6-mercaptopurine (6-mp) and BUN
Bacille Calmette-Guérin (BCG)
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6-mercaptopurine (6-mp) and Bacille Calmette-Guérin (BCG)
Beta-2 microglobulin
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6-mercaptopurine (6-mp) and Beta-2 microglobulin
Biopsy
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6-mercaptopurine (6-mp) and Biopsy
Biopsy skin
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Bladder tumor antigen (BTA)
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6-mercaptopurine (6-mp) and Bladder tumor antigen (BTA)
Brachytherapy
Sealed source radiotherapy
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6-mercaptopurine (6-mp) and Brachytherapy
Brain MRI
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6-mercaptopurine (6-mp) and Brain MRI
Breast Self Exams
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6-mercaptopurine (6-mp) and Breast Self Exams
Brush Cytology
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6-mercaptopurine (6-mp) and Brush Cytology
CA 125 (cancer antigen 125)
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6-mercaptopurine (6-mp) and CA 125 (cancer antigen 125)
CA 15-3 (cancer antigen 15.3)
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6-mercaptopurine (6-mp) and CA 15-3 (cancer antigen 15.3)
CA 19-9 (cancer antigen 19-9)
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6-mercaptopurine (6-mp) and CA 19-9 (cancer antigen 19-9)
CA 27.29 ((cancer antigen 27.29)
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6-mercaptopurine (6-mp) and CA 27.29 ((cancer antigen 27.29)
CA 72-4 (cancer antigen 72-4)
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6-mercaptopurine (6-mp) and CA 72-4 (cancer antigen 72-4)
CT Guided Needle Biopsy
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6-mercaptopurine (6-mp) and CT Guided Needle Biopsy
CT Pelvis
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related medication for '6-mercaptopurine (6-mp)'
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82
drugs
5-fluorouracil (5-fu)
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6-mercaptopurine (6-mp) and 5-fluorouracil (5-fu)
actinomycin-d
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6-mercaptopurine (6-mp) and actinomycin-d
alemtuzumab
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6-mercaptopurine (6-mp) and alemtuzumab
alkylating agents
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6-mercaptopurine (6-mp) and alkylating agents
altretamine
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6-mercaptopurine (6-mp) and altretamine
anastrozole
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6-mercaptopurine (6-mp) and anastrozole
anti tumor antibiotics
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6-mercaptopurine (6-mp) and anti tumor antibiotics
antimetabolites
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6-mercaptopurine (6-mp) and antimetabolites
arsenic trioxide
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6-mercaptopurine (6-mp) and arsenic trioxide
bevacizumab
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6-mercaptopurine (6-mp) and bevacizumab
bexarotene
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6-mercaptopurine (6-mp) and bexarotene
bicalutamide
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6-mercaptopurine (6-mp) and bicalutamide
bleomycin
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6-mercaptopurine (6-mp) and bleomycin
bortezomib
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6-mercaptopurine (6-mp) and bortezomib
busulfan
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6-mercaptopurine (6-mp) and busulfan
capecitabine
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carmustine (bcnu)
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6-mercaptopurine (6-mp) and carmustine (bcnu)
cetuximab
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6-mercaptopurine (6-mp) and cetuximab
chlorambucil
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6-mercaptopurine (6-mp) and chlorambucil
corticosteroids
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web search results for '6-mercaptopurine (6-mp)'?
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- 6-mercaptopurine (6-mp)
Mercaptopurine - Wikipedia, the free encyclopedia
Mercaptopurine (also called 6-Mercaptopurine, 6-MP or its brand name Purinethol) ... 6-MP ribonucleotide inhibits purine nucleotide synthesis and metabolism. ...
http://en.wikipedia.org/wiki/Mercaptopurine
en.wikipedia.org
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summary
Mercaptopurine
Drug details for Mercaptopurine. ... It is sometimes called 6-mercaptopurine, or 6-MP. How It Works ... Mercaptopurine is used to treat acute lymphocytic ...
http://www.webmd.com/cancer/mercaptopurine
www.webmd.com
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summary
Complications of pregnancy and child development after cessation of ...
PURPOSE: 6-Mercaptopurine (6-MP) has proven efficacy in the therapy of ... high doses, whereas human data suggest that 6-MP at maintenance doses is safe. ...
http://www.ncbi.nlm.nih.gov/pubmed/12642735
www.ncbi.nlm.nih.gov
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summary
Immunomodulators for inflammatory bowel disease - Yahoo! Health
Immunomodulator medicines, such as azathioprine (AZA), 6-mercaptopurine (6-MP), and methotrexate, weaken or suppress the immune system.
http://health.yahoo.com/digestive-medications/immunomodulato...
health.yahoo.com
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summary
Information on Crohn's Disease Symptoms, Causes, Diagnosis, and ...
Azathioprine (Imuran) and 6-mercaptopurine (6-MP, Purinethol) Infliximab (Remicade) ... modulators are 6-mercaptopurine (6-MP), azathioprine (Imuran), methotrexate ...
http://www.medicinenet.com/crohns_disease/page11.htm
www.medicinenet.com
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summary
Side Effects - Mercaptopurine [Purinethol, 6-MP]
Reference material for Mercaptopurine (also called Purinethol or 6-MP), an immunosuppresive medication that is used in the treatment of Inflammatory Bowel Disease.
http://ibdcrohns.about.com/cs/prescriptiondrugs/p/med6mp.htm
ibdcrohns.about.com
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summary
Thiopurine Drugs Azathioprine and 6-Mercaptopurine Inhibit ...
Both 6-MP and AZA had antibacterial activity against M. paratuberculosis; ... drugs azathioprine (AZA; Imuran) and its metabolite 6-mercaptopurine (6-MP) are ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pub...
www.pubmedcentral.nih.gov
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summary
Immunomodulators for inflammatory bowel disease
... as azathioprine (AZA), 6-mercaptopurine (6-MP), and methotrexate, weaken ... Azathioprine (AZA) and 6-mercaptopurine (6-MP) are used for moderate to severe ...
http://www.webmd.com/ibd-crohns-disease/immunomodulators-for...
www.webmd.com
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summary
6-mercaptopurine metabolite levels in children with inflammatory bowel ...
... suggest that efficacy of 6-mercaptopurine (6-MP) in patients with inflammatory ... However, serial monitoring of 6-MP metabolite levels in individual ...
http://www.ncbi.nlm.nih.gov/pubmed/11698762
www.ncbi.nlm.nih.gov
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summary
6-Mercaptopurine metabolism in Crohn's disease: correlation with ...
BACKGROUND: 6-Mercaptopurine (6-MP) has confirmed short and longterm efficacy in ... 6-MP induced complications (hepatitis, pancreatitis, and marrow suppression) ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1383347
www.pubmedcentral.nih.gov
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summary
Increased dosing requirements for 6-mercaptopurine and azathioprine in ...
BACKGROUND: 6-Mercaptopurine (6-MP) and its prodrug azathioprine (AZA) are ... No patients had to discontinue 6-MP/AZA, and all laboratory abnormalities ...
http://www.ncbi.nlm.nih.gov/pubmed/18266236
www.ncbi.nlm.nih.gov
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summary
Immunosuppressants
... known as immunnosuppressants (Imuran, Cyclosporine, 6-MP, and Methotrexate) including side-effects, drug ... Mercaptopurine (Purinethol, 6-MP) Side Effects ...
http://ibdcrohns.about.com/od/immunosuppressants/Immunosuppressants.htm
ibdcrohns.about.com
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summary
The ten-year single-center experience with 6-mercaptopurine in the ...
... bowel disease (IBD) with relatively lower dose of 6-mercaptopurine (6-MP) ... Four patients continued 6-MP throughout pregnancies and had normal outcomes. ...
http://www.ncbi.nlm.nih.gov/pubmed/15599205
www.ncbi.nlm.nih.gov
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summary
Enhanced Toxicity for Mice of 6-Mercaptopurine with Bacterial Endotoxin
... were also capable of potentiating the lethality of 6-mercaptopurine (6-MP) ... When 6-MP and LPS were administered simultaneously with either bacterial species, ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=428985
www.pubmedcentral.nih.gov
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summary
6-Mercaptopurine is effective in Crohn's disease without concomitant ...
BACKGROUND: 6-Mercaptopurine (6-MP) has shown efficacy in the treatment of ... Sparse literature to date suggests that 6-MP is effective when used without steroids. ...
http://www.ncbi.nlm.nih.gov/pubmed/15168805
www.ncbi.nlm.nih.gov
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summary
Mercaptopurine - Yahoo! Health
Mercaptopurine is available as a pill you can swallow. It is sometimes called 6-mercaptopurine, or 6-MP. ... sometimes called 6-mercaptopurine, or 6-MP. How It ...
http://health.yahoo.com/digestive-medications/mercaptopurine...
health.yahoo.com
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summary
Imuran Official FDA information, side effects and uses.
Accurate, FDA approved Imuran information for healthcare professionals and patients - brought to you ... Azathioprine is metabolized to 6-mercaptopurine (6-MP) ...
http://www.drugs.com/pro/imuran.html
www.drugs.com
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summary
Ulcerative Colitis Causes, Symptoms, Diagnosis, and Treatment by ...
... azathioprine (Imuran), 6-mercaptopurine (6-MP, Purinethol), cyclosporine ... Azathioprine and 6-mercaptopurine (6-MP) are medications that weaken the body's ...
http://www.medicinenet.com/ulcerative_colitis/page7.htm
www.medicinenet.com
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summary
Red blood cell hypoxanthine phosphoribosyltransferase activity measured ...
1. 6-Mercaptopurine (6-MP) is used in the continuing chemotherapy of childhood ... But there is an apparent sex difference in 6-MP metabolism. ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1364679
www.pubmedcentral.nih.gov
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summary
Allergic reactions to 6-mercaptopurine during trea...[J Clin ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE and ... to 6-mercaptopurine (6-MP) or ...
http://www.ncbi.nlm.nih.gov/pubmed/10372932
www.ncbi.nlm.nih.gov
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summary
6-Thioguanine in azathioprine and 6-mercaptopurine intolerant patients ...
Azathioprine (AZA) and 6-mercaptopurine (6-MP) are frequently used in the ... Two patients were intolerant to 6-MP, 5 to AZA and two to both drugs. ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1874347
www.pubmedcentral.nih.gov
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summary
Efficacy of mycophenolate mofetil in patients failing 6-mercaptopurine ...
... who failed or were intolerant of 6-mercaptopurine (6-MP) or azathioprine (AZA) ... Reasons for 6-MP/AZA intolerance or failure were recorded. ...
http://www.ncbi.nlm.nih.gov/pubmed/10701145
www.ncbi.nlm.nih.gov
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summary
Assay of azathioprine, 6-mercaptopurine and a novel thiopurine ...
... A simple, specific assay for 6-mercaptopurine (6-MP) in human plasma with a ... 2 6-MP was extracted directly from plasma into toluene using a novel ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1429803
www.pubmedcentral.nih.gov
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summary
Crohn's Disease - Treatment Overview - Yahoo! Health
The main treatment for Crohn's disease is medicine to stop the inflammation in the intestine and medicine to prevent ... (AZA), 6-mercaptopurine (6-MP), or ...
http://health.yahoo.com/digestive-treatment/crohn-s-disease-...
health.yahoo.com
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summary
Mercaptopurine Official FDA information, side effects and uses.
Accurate, FDA approved Mercaptopurine information for healthcare professionals ... Mechanism of Action: Mercaptopurine (6-MP) competes with hypoxanthine and ...
http://www.drugs.com/pro/mercaptopurine.html
www.drugs.com
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summary
Severe pulmonary toxicity after azathioprine/6-mercaptopurine ...
Azathioprine and 6-mercaptopurine (6-MP) are effective in inflammatory bowel disease (IBD) ... toxicity due to azathioprine/6-MP has been reported infrequently. ...
http://www.ncbi.nlm.nih.gov/pubmed/17667053
www.ncbi.nlm.nih.gov
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summary
Pharmacogenomics and metabolite measurement for 6-mercaptopurine ...
... 6-mercaptopurine (6-MP) are mediated via its intracellular conversion to 6-thioguanine (6-TG) and ... CONCLUSIONS: 6-MP metabolite levels and TPMT ...
http://www.ncbi.nlm.nih.gov/pubmed/10734022
www.ncbi.nlm.nih.gov
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summary
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS: THE EFFECT OF 6-MERCAPTOPURINE
1. 6-Mercaptopurine (6-MP) prevents experimental allergic encephalomyelitis (EAE) ... It is, rather, the result of 6-MP's specific anti-immunologic activity. ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2137550
www.pubmedcentral.nih.gov
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summary
How are Azathioprine and 6-mercaptopurine dosed by...[Inflamm Bowel Dis ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 ... Azathioprine (AZA) and 6-mercaptopurine (6-MP) are accepted as effective ...
http://www.ncbi.nlm.nih.gov/pubmed/18088072?ordinalpos=14&it...
www.ncbi.nlm.nih.gov
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summary
6-Mercaptopurine, an activator of Nur77, enhances ...[Oncogene. 2007 ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE and ... that 6-mercaptopurine (6-MP), an ...
http://www.ncbi.nlm.nih.gov/pubmed/17146432
www.ncbi.nlm.nih.gov
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summary
On the Action of Methotrexate and 6-Mercaptopurine on M. avium ...
... treated with methotrexate and 6-mercaptopurine (6-MP) is associated with a ... We show that methotrexate and 6-MP inhibit MAP growth in vitro. ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1779805
www.pubmedcentral.nih.gov
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summary
Azathioprine Official FDA information, side effects and uses.
Accurate, FDA approved Azathioprine information for healthcare professionals and patients - brought ... Azathioprine is metabolized to 6-mercaptopurine (6-MP) ...
http://www.drugs.com/pro/azathioprine.html
www.drugs.com
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summary
An open-label pilot study using thioguanine as a therapeutic ...
... a complete clinical response with 6-mercaptopurine (6-MP) and azathioprine (AZA) ... Seven of 10 patients had experienced dose-related 6-MP toxicities. ...
http://www.ncbi.nlm.nih.gov/pubmed/11515842
www.ncbi.nlm.nih.gov
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summary
The safety of 6-mercaptopurine for childbearing pa...[Gastroenterology ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE and ... of 6-mercaptopurine (6-MP), we ...
http://www.ncbi.nlm.nih.gov/pubmed/12512024
www.ncbi.nlm.nih.gov
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summary
Treatment for Crohn's Disease - WebMD
Treatment for Crohn's disease involves medications to prevent flare - ups, or ... 6-mercaptopurine [6-MP], or methotrexate) keep your disease in remission, you ...
http://www.webmd.com/ibd-crohns-disease/crohns-disease/tc/cr...
www.webmd.com
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summary
Decrease in S-adenosylmethionine synthesis by 6-mercaptopurine and ...
6-Mercaptopurine (6-MP) and methylmercaptopurine ribonucleoside (Me-MPR) are ... 6-MP is converted into tIMP, and thereafter it is methylated to Me-tIMP by ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1137466
www.pubmedcentral.nih.gov
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summary
Purinethol Official FDA information, side effects and uses.
Mercaptopurine, known chemically as 1,7-dihydro-6H-purine-6-thione monohydrate, ... Mercaptopurine (6-MP) competes with hypoxanthine and guanine for the enzyme ...
http://www.drugs.com/pro/purinethol.html
www.drugs.com
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summary
Choice of azathioprine or 6-mercaptopurine dose ba ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE ... or 6-mercaptopurine (6-MP) dose based ...
http://www.ncbi.nlm.nih.gov/pubmed/16795981
www.ncbi.nlm.nih.gov
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summary
Anti-inflammatory and immunosuppressive drugs and reproduction
Azathioprine and 6-mercaptopurine (6-MP) Methotrexate (MTX) Cyclophosphamide (CYC) ... 6-MP = 6-mercaptopurine; AAP = American Academy of Pediatrics; CI = confidence ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pub...
www.pubmedcentral.nih.gov
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summary
Ulcerative Colitis - Treatment Overview - Yahoo! Health
Treatment for ulcerative colitis depends mainly on the severity of the disease and ... medicines, such as azathioprine (AZA) or 6-mercaptopurine (6-MP), also ...
http://health.yahoo.com/other-other/ulcerative-colitis-treat...
health.yahoo.com
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summary
Effect of allopurinol on clinical outcomes in inflammatory bowel ...
... disease nonresponders to azathioprine or 6-mercaptopurine. ... 6-mercaptopurine (6-MP) preferentially metabolize 6-MP to 6-methylmercaptopurine (6-MMP) ...
http://www.ncbi.nlm.nih.gov/pubmed/17296529
www.ncbi.nlm.nih.gov
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summary
Outcome of pregnancies when fathers are treated with 6-mercaptopurine ...
... pregnancies after maternal use of 6-mercaptopurine (6-MP) for inflammatory bowel ... Group 1 comprised pregnancies fathered by men who were taking 6-MP. ...
http://www.ncbi.nlm.nih.gov/pubmed/10710057
www.ncbi.nlm.nih.gov
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summary
History of cancer chemotherapy - Wikipedia, the free encyclopedia
3 6-MP, vinca alkaloids and a National Treatment Effort by the US. 4 ... in the discovery of 6-mercaptopurine (6-MP), which was subsequently shown to ...
http://en.wikipedia.org/wiki/History_of_cancer_chemotherapy
en.wikipedia.org
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summary
Pharmacokinetics of 6-mercaptopurine in patients with inflammatory ...
... pharmacokinetic studies of 6-mercaptopurine (6-MP) in inflammatory bowel disease ... The authors have evaluated 6-MP pharmacokinetics in IBD patients, ...
http://www.ncbi.nlm.nih.gov/pubmed/15167634
www.ncbi.nlm.nih.gov
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summary
6-MP metabolite profiles provide a biochemical exp...[Gastroenterology ...
... (IBD) patients fail to benefit from 6-mercaptopurine (6-MP)/azathioprine (AZA) ... Pharmacokinetics of 6-mercaptopurine in patients with inflammatory bowel ...
http://www.ncbi.nlm.nih.gov/pubmed/11910342
www.ncbi.nlm.nih.gov
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summary
Use of allopurinol with low-dose 6-mercaptopurine in inflammatory bowel ...
... disease do not respond or are intolerant to therapy with 6-mercaptopurine (6-MP) ... Combination allopurinol and low-dose 6-MP is an effective means to achieve ...
http://www.ncbi.nlm.nih.gov/pubmed/18299738
www.ncbi.nlm.nih.gov
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summary
Safe treatment of thiopurine S-methyltransferase deficient Crohn's ...
... of azathioprine (AZA) and 6-mercaptopurine (6-MP) due to excessive accumulation ... with azathioprine (AZA) or 6-mercaptopurine (6-MP) even at standard doses ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1773505
www.pubmedcentral.nih.gov
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summary
Thiopurine drugs azathioprine and 6-mercaptopurine inhibit ...
Both 6-MP and AZA had antibacterial activity against M. paratuberculosis; ... AZA and 6-MP limited the growth of, but did not kill, M. paratuberculosis in a ...
http://www.ncbi.nlm.nih.gov/pubmed/18070971
www.ncbi.nlm.nih.gov
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summary
CD28-dependent Rac1 activation is the molecular target of azathioprine ...
Azathioprine and its metabolite 6-mercaptopurine (6-MP) are widely used as ... T cell stimulation for the analysis of azathioprine- and 6-MP?induced apoptosis. ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=152932
www.pubmedcentral.nih.gov
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summary
Azathioprine and 6-mercaptopurine for the treatmen...[J Clin ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE ... or 6-mercaptopurine (6-MP) for ...
http://www.ncbi.nlm.nih.gov/pubmed/10777191
www.ncbi.nlm.nih.gov
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summary
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