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5-fluorouracil (5-fu)
what is '5-fluorouracil (5-fu)'?
Definition for 5-fluorouracil (5-FU)
Fluorouracil (5-FU or f5U) is a pyrimidine analog , which is used as a drug in the treatment of cancer . It belongs to the family of drugs called antimetabolites . It is typically administered with leucovorin .
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Fluorouracil (5-FU or f5U) is a pyrimidine analog , which is used as a drug in the treatment of cancer . It belongs to the family of drugs called antimetabolites . It is typically administered with leucovorin .
The chemotherapy agent 5-FU (fluorouracil), which has been in use against cancer for about 40 years, acts in several ways, but principally as a thymidylate synthase inhibitor . Interrupting the action of this enzyme blocks synthesis of the pyrimidine thymidine , which is a nucleotide required for DNA replication . Thymidylate synthase methylates deoxyuridine monophoshate (dUMP) into thymidine monophosphate (dTMP).
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search results for diagnoses treated with '5-fluorouracil (5-fu)'
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diagnosis
carcinoma tongue
tongue cancer
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5-fluorouracil (5-FU) and carcinoma tongue
esophageal carcinoma
cancer of esophagus
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5-fluorouracil (5-FU) and esophageal carcinoma
renal cell carcinoma
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5-fluorouracil (5-FU) and renal cell carcinoma
gall bladder tumors
tumors of the gall bladder
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5-fluorouracil (5-FU) and gall bladder tumors
metastases
spread of malignant tumors to other body sites
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5-fluorouracil (5-FU) and metastases
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mouth cancer
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5-fluorouracil (5-FU) and oral cancer
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5-fluorouracil (5-FU) and tumors tongue
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5-fluorouracil (5-FU) and malignancy
midline granuloma
rare tumor of nose and paranasal sinuses
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5-fluorouracil (5-FU) and midline granuloma
somatostatinoma
tumor of pancreas
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5-fluorouracil (5-FU) and somatostatinoma
tumors of nose and paranasal sinuses
tumors of nose and sinuses
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5-fluorouracil (5-FU) and tumors of nose and paranasal sinuses
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search results for related procedures when taking '5-fluorouracil (5-fu)'
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procedures
Radiation Therapy
Use of ionizing radiation or xrays for medical imaging or to treat cancer
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5-fluorouracil (5-FU) and Radiation Therapy
Biopsy
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5-fluorouracil (5-FU) and Biopsy
Brachytherapy
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5-fluorouracil (5-FU) and Brachytherapy
CT scan
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5-fluorouracil (5-FU) and CT scan
Complete Blood Count
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5-fluorouracil (5-FU) and Complete Blood Count
Cytodiagnosis
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5-fluorouracil (5-FU) and Cytodiagnosis
External Beam Radiation
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5-fluorouracil (5-FU) and External Beam Radiation
CT chest
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5-fluorouracil (5-FU) and CT chest
Chemotherapy
Use of chemical substances to treat disease
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5-fluorouracil (5-FU) and Chemotherapy
Chest X-ray
Radiological technique to image the chest
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5-fluorouracil (5-FU) and Chest X-ray
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5-fluorouracil (5-FU) and Magnetic Resonance Imaging (MRI)
Incisional Biopsy
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Resection
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Liver Function Tests
elevated liver enzymes
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5-fluorouracil (5-FU) and Liver Function Tests
Endoscopic surgery
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5-fluorouracil (5-FU) and Endoscopic surgery
Fine Needle Aspiration (FNA) biopsy
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5-fluorouracil (5-FU) and Fine Needle Aspiration (FNA) biopsy
Complete metabolic panel
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related medication search results for '5-fluorouracil (5-fu)'
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drugs
bleomycin
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5-fluorouracil (5-FU) and bleomycin
methotrexate
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5-fluorouracil (5-FU) and methotrexate
paclitaxel
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5-fluorouracil (5-FU) and paclitaxel
cisplatin
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5-fluorouracil (5-FU) and cisplatin
cetuximab
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5-fluorouracil (5-FU) and cetuximab
docetaxel
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5-fluorouracil (5-FU) and docetaxel
carboplatin
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5-fluorouracil (5-FU) and carboplatin
ifosfamide
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5-fluorouracil (5-FU) and ifosfamide
doxorubicin
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5-fluorouracil (5-FU) and doxorubicin
fluorouracil(adrucil )
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5-fluorouracil (5-FU) and fluorouracil(adrucil )
gemcitabine(gemzar )
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5-fluorouracil (5-FU) and gemcitabine(gemzar )
vinblastine
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5-fluorouracil (5-FU) and vinblastine
capecitabine
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5-fluorouracil (5-FU) and capecitabine
gemcitabine
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5-fluorouracil (5-FU) and gemcitabine
bleomycin(blenoxane )
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5-fluorouracil (5-FU) and bleomycin(blenoxane )
carboplatin(paraplatin )
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5-fluorouracil (5-FU) and carboplatin(paraplatin )
docetaxel(taxotere )
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5-fluorouracil (5-FU) and docetaxel(taxotere )
paclitaxel(taxol , onxol)
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5-fluorouracil (5-FU) and paclitaxel(taxol , onxol)
cyclophosphamide
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5-fluorouracil (5-FU) and cyclophosphamide
irinotecan
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5-fluorouracil (5-FU) and irinotecan
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The following are types of physicians relevant for '5-fluorouracil (5-FU)'.
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web search results for '5-fluorouracil (5-fu)'?
Results
1 - 50
- 5-fluorouracil (5-FU)
Fluorouracil - Wikipedia, the free encyclopedia
Fluorouracil (5-FU or f5U) is a pyrimidine analog, which is used as a drug in ... The chemotherapy agent 5-FU (fluorouracil), which has been in use against cancer ...
http://en.wikipedia.org/wiki/Fluorouracil
en.wikipedia.org
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summary
Fluorouracil - 5 FU - 5-Fluorouracil ? Chemotherapy for Breast Cancer
... 5-Fluorouracil, and is part of the FAC combination chemo: 5-FU, Adriamycin, and Cytoxan. ... Label Details in Conventional Order for fluorouracil, 5-FU. ...
http://breastcancer.about.com/od/chemotherapydrugs/p/fluorouracil.htm
breastcancer.about.com
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summary
Cellular response to 5-fluorouracil (5-FU) in 5-FU...[Mol Cancer. 2006 ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE and ... drug 5-fluorouracil (5-FU) causes DNA ...
http://www.ncbi.nlm.nih.gov/pubmed/16709241
www.ncbi.nlm.nih.gov
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summary
Fluorouracil (5-FU) for nonmelanoma skin cancer
Drug details for Fluorouracil (5-FU) for nonmelanoma skin cancer. ... Fluorouracil (5-FU) is an anticancer medication that works by slowing or stopping cell growth. ...
http://www.webmd.com/melanoma-skin-cancer/fluorouracil-5-fu-...
www.webmd.com
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summary
metronidazole and 5 fu Drug Interactions
... and 5 fu Drug Interactions. Drug-drug and drug-food interactions between metronidazole and 5 fu ... Interactions between metronidazole and 5 fu (fluorouracil) ...
http://www.drugs.com/drug-interactions/metronidazole_d00108_5-fu_d00235.html
www.drugs.com
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summary
Linking uracil base excision repair and 5-fluorouracil toxicity in yeast
5-fluorouracil (5-FU) is a widely used anticancer drug that disrupts pyrimidine ... The prodrug 5-fluorouracil (5-FU) (Figure 1A) has historically been used to ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pub...
www.pubmedcentral.nih.gov
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summary
Fluorouracil Filtering Surgery Study (FFSS) [NEI Clinical Studies]
Clinical Trials Research Tool Supported by the NEI. ... subconjunctival injections of 5-fluorouracil (5-FU) increase the success ...
http://www.nei.nih.gov/neitrials/static/study21.asp
www.nei.nih.gov
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summary
5-FLUOROURACIL
5-Fluorouracil (5-FU) is a white to almost white odorless crystal-line compound, ... Rapid assay of 5-fluorouracil (5-FU) in plasma by GC-CIMS and stale ...
http://dohs.ors.od.nih.gov/pdf/5-Fluorouracil%20REVISED.pdf
dohs.ors.od.nih.gov
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summary
5-Fluorouracil (5-FU) and leucovorin in platinum-r...[Gynecol Oncol ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from ... 5-Fluorouracil (5-FU) and leucovorin in ...
http://www.ncbi.nlm.nih.gov/pubmed/1526510
www.ncbi.nlm.nih.gov
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summary
5-Fluorouracil-induced cardiotoxicity mimicking myocardial infarction ...
Severe 5-fluorouracil (5-FU) cardiotoxicity is unusual, but documented. ... Repeated exposure to 5-FU following an episode of cardiotoxicity carries a risk ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=60652
www.pubmedcentral.nih.gov
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summary
Fluorouracil
Drug details for Fluorouracil. ... Fluorouracil. Examples. Generic Name. Brand Name. fluorouracil. Adrucil, 5-FU. How It Works ...
http://www.webmd.com/cancer/fluorouracil
www.webmd.com
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summary
Xeloda (Capecitabine) Drug Information: Uses, Side Effects, Drug ...
... was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS) ... XELODA is changed in the body to 5-fluorouracil (5-FU) ...
http://www.rxlist.com/xeloda-drug.htm#cp
www.rxlist.com
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summary
NSC 19893
5-Fluorouracil. Arumel. Carzonal. Effluderm (free base) Efudex. Efudix. Fluoroblastin. Fluoroplex ... Fluorouracil(USAN) Fluracil. Fluri. Fluril. FU. Kecimeton ...
http://dtp.nci.nih.gov/docs/static_pages/compounds/19893.html
dtp.nci.nih.gov
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summary
Metabotropic glutamate receptor 4-mediated 5-Fluorouracil resistance in ...
PURPOSE: 5-Fluorouracil (5-FU) has been the mainstay treatment for colorectal ... Interestingly, 5-FU down-regulated mGluR4 expression, and MAP 4 suppressed ...
http://www.ncbi.nlm.nih.gov/pubmed/15217955
www.ncbi.nlm.nih.gov
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summary
Benefits of adjuvant therapy for rectal cancer
... that a sequential regimen of 5-fluorouracil (5-FU) based chemotherapy and ... LINDBLAD AS, et al. Radiation therapy and 5-fluorouracil (5-FU) with or without ...
http://www.nlm.nih.gov/databases/alerts/rectal_cancer.html
www.nlm.nih.gov
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summary
Irinotecan plus folinic acid/continuous 5-fluorouracil as simplified ...
... irinotecan, folinic acid (FA) and 5-fluorouracil (5-FU) has been proven to be ... 5-Fluorouracil (5-FU)-based chemotherapy, ? usually biomodulated with folinic ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=49...
www.pubmedcentral.nih.gov
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summary
ChemIDPlus/HSDB 51-21-8 Toxicity - National Toxicology Program
CASE REPORTS: Anaphylactic reactions to 5-fluorouracil (5-FU) are uncommon. ... EPIDEMIOLOGY STUDIES: AIM: 5-fluorouracil (5-FU) and its prodrug capecitabine ...
http://ntp.niehs.nih.gov/index.cfm?objectid=D38B5D0F-BDB5-82F8-F89946043B3AC646
ntp.niehs.nih.gov
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summary
Cyclophosphamide Methotrexate Fluorouracil - Wikipedia, the free ...
... anti-cancer agents: cyclophosphamide, methotrexate, and 5-fluorouracil (5-FU).[1] ... On days 1 and 8 methotraxate and 5-FU are given as injections. ...
http://en.wikipedia.org/wiki/CMF_(chemotherapy)
en.wikipedia.org
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summary
Xeloda Official FDA information, side effects and uses.
This drug is enzymatically converted to 5-fluorouracil (5-FU) in vivo. Bioactivation ... non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease ...
http://www.drugs.com/pro/xeloda.html
www.drugs.com
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summary
The relationship between 5-fluorouracil sensitivit...[Oncol Rep. 2006 ...
... playing an important role in exertion of the effect of 5-fluorouracil (5-FU) ... [Correlation between 5-fluorouracil (5-FU) sensitivity as measured by collagen ...
http://www.ncbi.nlm.nih.gov/pubmed/16328050
www.ncbi.nlm.nih.gov
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summary
An intravitreal biodegradable sustained release naproxen and 5 ...
... such as daunomycin and 5-fluorouracil (5-FU), have been suggested as therapy ... release of naproxen and 5-fluorouracil from NA/5-FU codrug pellets placed in 50 ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1772295
www.pubmedcentral.nih.gov
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summary
www.nci.nih.gov/dictionary/db_alpha.aspx?expand=5
5-FU. A drug used in the treatment of cancer. It is a type of antimetabolite. Also called fluorouracil. 5-HT3 receptor antagonist (...reh-SEP-ter an-TAG-uh-nist ) ...
http://www.nci.nih.gov/dictionary/db_alpha.aspx?expand=5
www.nci.nih.gov
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summary
Optimisation of 5-fluorouracil (5-FU)/cisplatin co...[Eur J Cancer ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE and ... of 5-fluorouracil (5-FU)/cisplatin ...
http://www.ncbi.nlm.nih.gov/pubmed/11916548?dopt=Abstract
www.ncbi.nlm.nih.gov
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summary
5-Fluorouracil and Gemcitabine Potentiate the Efficacy of Oncolytic ...
While 5-fluorouracil (5-FU)- and gemcitabine-based regimens have demonstrated ... Doses of 5-fluorouracil (5-FU) and NV1066 needed to kill various fractions (Fa) ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pub...
www.pubmedcentral.nih.gov
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summary
Complete Capecitabine information from Drugs.com
All about Capecitabine. View complete and up to date Capecitabine ... an oral systemic prodrug that is enzymatically converted to 5-fluorouracil (5-FU) ...
http://www.drugs.com/ppa/capecitabine.html
www.drugs.com
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Carcinoid Syndrome Glossary of Terms with Definitions on MedicineNet.com
Carcinoid Syndrome glossary includes a list of Carcinoid Syndrome related medical definitions and ... Full name: 5-fluorouracil. Abbreviation: 5-FU . See the ...
http://www.medicinenet.com/carcinoid_syndrome/glossary.htm
www.medicinenet.com
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summary
Chemoradiotherapy with or without consolidation chemotherapy using ...
CRT with 5-fluorouracil (5-FU) and mitomicin-C (MMC) has also been evaluated in ... RTOG 98-11: A phase III randomized study of 5-fluorouracil (5-FU), mitomycin, ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2245963
www.pubmedcentral.nih.gov
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Living with Cancer Chemotherapy
Leucovorin/5-Fluorouracil ... 5-FU blocks a protein that cancer cells need to copy and repair. DNA. Leucovorin helps 5-FU block this protein. DNA is the ...
http://www.cc.nih.gov/ccc/patient_education/CaTxeng/leucov.pdf
www.cc.nih.gov
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summary
5-fluorouracil activation of p53 involves an MDM2-ribosomal protein ...
5-fluorouracil (5-FU) is a widely used chemotherapeutic drug for the treatment ... The anti-tumor activity of 5-FU has been attributed in part to its ability to ...
http://www.ncbi.nlm.nih.gov/pubmed/17242401
www.ncbi.nlm.nih.gov
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Oxaliplatin Drug Information, Professional
In combination with 5-fluorouracil (5-FU), oxaliplatin exhibits in vitro and in ... 5-Fluorouracil (5-FU) (5-FU plasma concentrations are increased approximately 20 ...
http://www.drugs.com/mmx/oxaliplatin.html
www.drugs.com
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summary
Sorivudine and 5-fluorouracil; a clinically significant drug-drug ...
... 1) and the cancer chemotherapy drug 5-fluorouracil (5-FU) ... Importance of dihydropyrimidine dehydrogenase (DPD) in 5-fluorouracil (5-FU) pharmacology. ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1873978
www.pubmedcentral.nih.gov
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summary
Bioactivation of tegafur to 5-fluorouracil is cata...[Clin Cancer Res ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE and ... of 5-fluorouracil (5-FU) consisting ...
http://www.ncbi.nlm.nih.gov/pubmed/11106261
www.ncbi.nlm.nih.gov
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summary
Schedule-selective biochemical modulation of 5-fluorouracil in advanced ...
5-FU: 5-fluorouracil. PALA: N-phosphonacetyl-L-aspartic acid. IFNa?-2a: ... the synergy between oxaliplatin (LOHP) and 5 fluorouracil (FU)-folinic acid (FA) ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=113263
www.pubmedcentral.nih.gov
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summary
5-Fluorouracil dose escalation enabled with PN401 ...[Cancer Chemother ...
... dose escalation of 5-fluorouracil (5-FU) with consequent improvements in antitumor efficacy. ... II trial of PN401, 5-FU, and leucovorin in unresectable or ...
http://www.ncbi.nlm.nih.gov/pubmed/16187114
www.ncbi.nlm.nih.gov
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Clinical Significance of Dihydropyrimidine Dehydrogenase in Adjuvant 5 ...
... dehydrogenase (DPD) expression and response to 5-fluorouracil (5-FU) liver ... using 250 mg/d/body of 5-fluorouracil (5-FU) via both portal vein and hepatic ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1356490
www.pubmedcentral.nih.gov
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Irinotecan Ineffective After Colon Cancer Surgery - National Cancer ...
Irinotecan should not be added to 5-fluorouracil (5-FU) and leucovorin in the post-surgical treatment of stage III colon cancer, according to the Aug. 10, 2007, ...
http://www.nci.nih.gov/clinicaltrials/results/irinotecan0807
www.nci.nih.gov
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summary
Trabeculectomy - Wikipedia, the free encyclopedia
... C (MMC, 0.5-0.2 mg/ml) or 5-fluorouracil (5-FU, 50 mg/ml) soaked sponges. ... subconjunctival 5-FU injections can prevent conjunctiva from adhering down ...
http://en.wikipedia.org/wiki/Trabeculectomy
en.wikipedia.org
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Leucovorin Official FDA information, side effects and uses.
Accurate, FDA approved Leucovorin information for healthcare ... 5-fluorouracil (5-FU) 370 mg/m2 versus LV 20 mg/m2 and 5-FU 425 mg/m2 versus 5-FU 500 mg/m2. ...
http://www.drugs.com/pro/leucovorin-injection.html
www.drugs.com
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summary
Pharmacokinetics of 5-fluorouracil in the hamster ...[J Pharm Sci. 2006 ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE and ... of 5-fluorouracil (5-FU) in lipid ...
http://www.ncbi.nlm.nih.gov/pubmed/16639722/
www.ncbi.nlm.nih.gov
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Swainsonine reduces 5-fluorouracil tolerance in the multistage ...
... mechanisms of resistance to 5-fluorouracil (5-FU) was established from a ... 5-fluorouracil (5-FU), a fluorinated pyrimidine, is a key anti-colorectal cancer ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pub...
www.pubmedcentral.nih.gov
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Fluorouracil Improves Glaucoma Surgery Outcome [NEI News and Events]
... by injections of the drug, 5-fluorouracil (5-FU), beneath the outer membrane of the eye. ... injections of 5-fluorouracil also called 5-FU, could enhance ...
http://www.nei.nih.gov/news/pressreleases/ffsspressrelease.asp
www.nei.nih.gov
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summary
Phase I/II study of first-line irinotecan combined with 5-fluorouracil ...
Until recently, 5-fluorouracil (5-FU) in combination with folinic acid (FA) has ... colorectal cancer truly resistant to 5-fluorouracil (5-FU). Eur J Cancer. ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=493270
www.pubmedcentral.nih.gov
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Treatment of conjunctival squamous cell carcinoma with topical 5 ...
... the efficacy of topical 5-fluorouracil (5-FU) alone, without concurrent surgery ... Topical 5-fluorouracil in treating epithelial neoplasia of the ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1723406
www.pubmedcentral.nih.gov
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summary
Effects of 5-fluorouracil and leucovorin in the tr...[Am J Clin Oncol ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE and ... 5-Fluorouracil (5-FU) is the most ...
http://www.ncbi.nlm.nih.gov/pubmed/10955877
www.ncbi.nlm.nih.gov
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summary
5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics ...
... the rate-determining enzyme in 5-fluorouracil (5-FU) catabolism. ... pharmacokinetic characteristics of 5-fluorouracil (5-FU) in colorectal cancer patients. ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=47922
www.pubmedcentral.nih.gov
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flagyl-er and Capecitabine Drug Interactions
flagyl-er and Capecitabine Drug Interactions. Drug-drug and drug-food interactions ... with a nitroimidazole may increase the toxicity of 5-fluorouracil (5-FU) ...
http://www.drugs.com/drug-interactions/flagyl-er_d00108_capecitabine_d04311.html
www.drugs.com
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Definition of tegafur-uracil - National Cancer Institute Drug Dictionary
... 5-fluorouracil (5-FU) congener prodrug tegafur (tetrahydrofuranyl-5-fluorouracil) ... Tegafur is bioactivated to 5-FU by liver microsomal cytochrome P450 enzymes. ...
http://www.nci.nih.gov/Templates/drugdictionary.aspx?CdrID=461135
www.nci.nih.gov
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summary
Effects of folylpolyglutamate synthetase modulation on chemosensitivity ...
... not typically considered as antifolates such as 5-fluorouracil (5-FU) ... 5-FU, 5-fluorouracil. GGH, ?-glutamyl hydrolase. LV, leucovorin. MTX, methotrexate ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1774322
www.pubmedcentral.nih.gov
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summary
Breast Cancer
Cyclophosphamide, 5-fluorouracil (5-FU), and methotrexate (CMF) ... that may be a good substitute for 5-FU and when used alone may an effective ...
http://adam.about.com/reports/000006_10.htm
adam.about.com
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summary
Survival after adjuvant 5-FU treatment for stage I...[Int J Cancer ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE ... efficacy of 5-Fluorouracil (5-FU) in MSI ...
http://www.ncbi.nlm.nih.gov/pubmed/14961589
www.ncbi.nlm.nih.gov
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summary
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