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2-chlorodeoxyadenosine
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what is '2-chlorodeoxyadenosine'?
Definition for 2-chlorodeoxyadenosine
Cladribine (Leustatin) is a drug used to treat hairy cell leukemia (leukemic reticuloendotheliosis) and multiple sclerosis . Its chemical name is 2-chlorodeoxyadenosine (2CDA).
As a purine analog , it is a synthetic anti-cancer agent that also suppresses the immune system.
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Cladribine (Leustatin) is a drug used to treat hairy cell leukemia (leukemic reticuloendotheliosis) and multiple sclerosis . Its chemical name is 2-chlorodeoxyadenosine (2CDA).
As a purine analog , it is a synthetic anti-cancer agent that also suppresses the immune system. Chemically, it mimics the nucleoside adenosine and thus inhibits the enzyme adenosine deaminase , which interferes with the cell's ability to process DNA. It is easily destroyed by normal cells except for blood cells, with the result that it produces relatively few side effects and results in very little non-target cell loss.
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diagnoses treated with '2-chlorodeoxyadenosine'
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1
diagnosis
Sezary's Syndrome
leukemic variant of T cell lymphoma in skin
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2-chlorodeoxyadenosine and Sezary's Syndrome
related procedures when taking '2-chlorodeoxyadenosine'
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16
procedures
CD4 T cells
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2-chlorodeoxyadenosine and CD4 T cells
Biopsy skin
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2-chlorodeoxyadenosine and Biopsy skin
CD3 T cells
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2-chlorodeoxyadenosine and CD3 T cells
CD4 /CD8 cell ratio
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2-chlorodeoxyadenosine and CD4 /CD8 cell ratio
CD8 T cells
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2-chlorodeoxyadenosine and CD8 T cells
CD8 T cells
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2-chlorodeoxyadenosine and CD8 T cells
Flow Cytometry
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2-chlorodeoxyadenosine and Flow Cytometry
Lymph node biopsy
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2-chlorodeoxyadenosine and Lymph node biopsy
Polymerase Chain Reaction (PCR)
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2-chlorodeoxyadenosine and Polymerase Chain Reaction (PCR)
Sézary cell count
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2-chlorodeoxyadenosine and Sézary cell count
T cell clone in blood by Southern blot or PCR
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2-chlorodeoxyadenosine and T cell clone in blood by Southern blot or PCR
T-cell subsets CD3, CD4, CD8
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2-chlorodeoxyadenosine and T-cell subsets CD3, CD4, CD8
Ultrasound lymph node
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2-chlorodeoxyadenosine and Ultrasound lymph node
cDNA arrays
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2-chlorodeoxyadenosine and cDNA arrays
chromosomally abnormal T cell clone
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2-chlorodeoxyadenosine and chromosomally abnormal T cell clone
extracorporeal photochemotherapy
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2-chlorodeoxyadenosine and extracorporeal photochemotherapy
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related medication for '2-chlorodeoxyadenosine'
1 - 5 of
8
drugs
bexarotene trial
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2-chlorodeoxyadenosine and bexarotene trial
chlorambucil
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2-chlorodeoxyadenosine and chlorambucil
deoxycoformycin
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2-chlorodeoxyadenosine and deoxycoformycin
fludarabine monophosphate
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2-chlorodeoxyadenosine and fludarabine monophosphate
mercaptopurine
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2-chlorodeoxyadenosine and mercaptopurine
methotrexate
web search for:
2-chlorodeoxyadenosine and methotrexate
monoclonal antibodies trial
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2-chlorodeoxyadenosine and monoclonal antibodies trial
prednisone
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2-chlorodeoxyadenosine and prednisone
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The following are types of physicians relevant for '2-chlorodeoxyadenosine'.
related types of physicians 'dermatologist, family practitioner, internist, oncologist'
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web search results for '2-chlorodeoxyadenosine'?
Results
1 - 50
- 2-chlorodeoxyadenosine
The 2-chlorodeoxyadenosine-induced cell death signalling pathway in ...
2-Chlorodeoxyadenosine-induced apoptosis did not involve increases in the ... Addition of 2-chlorodeoxyadenosine induced an increase in the amount of p53 in ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1136039
www.pubmedcentral.nih.gov
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summary
Cladribine - Wikipedia, the free encyclopedia
... leukemia with cladribine (2-chlorodeoxyadenosine) by subcutaneous bolus ... Infectious complications after 2-chlorodeoxyadenosine therapy". Eur. J. Haematol. ...
http://en.wikipedia.org/wiki/Cladribine
en.wikipedia.org
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summary
Hairy Cell Leukemia
... of choice are either cladribine (2-chlorodeoxyadenosine,2-CdA) or pentostatin. ... with hairy cell leukemia following treatment with 2-chlorodeoxyadenosine. ...
http://www.webmd.com/cancer/tc/leukemia-hairy-cell-treatment...
www.webmd.com
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summary
Infectious complications after 2-chlorodeoxyadenos...[Eur J Haematol ...
Weekly administration of 2-chlorodeoxyadenosine in patients with hairy-cell ... 2-Chlorodeoxyadenosine treatment in non-Hodgkin's lymphoma and B-cell chronic ...
http://www.ncbi.nlm.nih.gov/pubmed/8641392
www.ncbi.nlm.nih.gov
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summary
Leukemia, hairy cell: Treatment - Health Professional Information [NCI ...
Hairy cell leukemia is a chronic lymphoproliferative disorder that is easily ... Cladribine (2-chlorodeoxyadenosine, 2-CdA) given intravenously by continuous ...
http://health.yahoo.com/leukemia-treatment/leukemia-hairy-ce...
health.yahoo.com
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summary
Cladribine Drug Information, Professional
Cladribine Drug Information from Drugs.com. Includes Cladribine side effects, interactions ... Pentostatin and 2-chlorodeoxyadenosine for hairy-cell leukemia. ...
http://www.drugs.com/MMX/Cladribine.html
www.drugs.com
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summary
Hairy Cell Leukemia Treatment - National Cancer Institute
Expert-reviewed information summary about the treatment of hairy cell leukemia. ... Cladribine (2-chlorodeoxyadenosine, 2-CdA) given intravenously by continuous ...
http://www.nci.nih.gov/cancertopics/pdq/treatment/hairy-cell...
www.nci.nih.gov
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summary
Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to ...
... plus deoxycoformycin, or with 2-chlorodeoxyadenosine (CdA), an ADA resistant ... A. Specific toxicity of 2-chlorodeoxyadenosine toward resting and proliferating ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=2579098
www.pubmedcentral.nih.gov
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summary
Cladribine - PubChem Public Chemical Database
PubChem Compound Summary ... 2-CdA. 2 Chlorodeoxyadenosine. 2-Chloro-2'-deoxy-beta-adenosine ... c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17) ...
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=20279
pubchem.ncbi.nlm.nih.gov
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summary
Gastrointestinal involvement in disseminated Lange...[J Pediatr Hematol ...
Ultimately, two cycles of 2-chlorodeoxyadenosine concomitant with high-dose ... [Results of treatment with 2-chlorodeoxyadenosine in refractory or relapsed ...
http://www.ncbi.nlm.nih.gov/pubmed/12794533
www.ncbi.nlm.nih.gov
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summary
MedlinePlus Drug Information: Drugs beginning with 0-9
0.9% Sodium Chloride see Sodium Chloride (Catheter Flush) Injection. 2-CdA see Cladribine. 2-chlorodeoxyadenosine see Cladribine. 3TC see Lamivudine ...
http://www.nlm.nih.gov/medlineplus/druginfo/drug_00.html
www.nlm.nih.gov
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summary
Hairy Cell Leukemia
Note: Some citations in the text of this section are followed by a level of evidence. ... Cladribine (2-chlorodeoxyadenosine, 2-CdA) and pentostatin are both highly ...
http://www.webmd.com/cancer/tc/leukemia-hairy-cell-treatment...
www.webmd.com
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summary
2 - 29 Professional Drug Info Index
2-CdA. 2-Chlorodeoxyadenosine. 2-PAM. 2-PAM chloride. 2,3-dideoxyinosine. 2.5 Benzagel Acne Gel ... 2'-deoxycoformycin. 2'DCF. 201Tl. 206 Shake. 217. 217 ...
http://www.drugs.com/mmx21.html
www.drugs.com
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summary
Potent toxicity of 2-chlorodeoxyadenosine toward human monocytes in ...
Potent toxicity of 2-chlorodeoxyadenosine toward human monocytes in vitro and in ... 2-Chlorodeoxyadenosine: an effective new agent for the treatment of chronic ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=1700795
www.pubmedcentral.nih.gov
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summary
Clinical Study: 06-C-0150, A Phase II Clinical Trial of Anti-Tac(Fv ...
Clinical Study Summary Sheet for 06-C-0150 ... leukemia-variant treated with 2-chlorodeoxyadenosine--a report of three cases. ...
http://clinicalstudies.info.nih.gov/cgi/detail.cgi?A_06-C-0150.html
clinicalstudies.info.nih.gov
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summary
[Results of treatment with 2-chlorodeoxyadenosine in refractory or ...
[Results of treatment with 2-chlorodeoxyadenosine in refractory or relapsed ... results of the treatment with 2-chlorodeoxyadenosine (2CdA) in 9 patients with ...
http://www.ncbi.nlm.nih.gov/pubmed/11333766
www.ncbi.nlm.nih.gov
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summary
eMedicine - Hairy Cell Leukemia : Article by Emmanuel C Besa
Hairy cell leukemia (HCL) is a chronic lymphoid leukemia that was originally ... Cladribine or 2-chlorodeoxyadenosine (Leustatin) Description ...
http://www.emedicine.com/med/topic937.htm
www.emedicine.com
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summary
Chapter 11: Chemotherapy-Related Nausea & Vomiting: Phases of ...
The Symptom Research interactive clinical research textbook contains over 20 ... 2-Chlorodeoxyadenosine. Fludarabine. Hydroxyurea. Methotrexate < 50 mg/m2 ...
http://symptomresearch.nih.gov/Chapter_11/sec4/cgms4pg5.htm
symptomresearch.nih.gov
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summary
Deoxycytidine kinase - Wikipedia, the free encyclopedia
280 (2): 363?6. PMID 2013338. Yamada Y, Goto H, Ogasawara N (1984) ... kinase and phosphorylation of 2-chlorodeoxyadenosine in human normal and tumour ...
http://en.wikipedia.org/wiki/Deoxycytidine_kinase
en.wikipedia.org
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summary
Adult Non-Hodgkin's Lymphoma
Optimal treatment of advanced stages of low-grade lymphoma is controversial ... such as fludarabine or 2-chlorodeoxyadenosine, oral alkylating agents (with or ...
http://www.webmd.com/cancer/non-hodgkins-lymphoma/tc/ncicdr0...
www.webmd.com
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summary
Definition of cladribine - National Cancer Institute Drug Dictionary
Virtual and Standard Colonoscopy Both Accurate. NCI Responds to Hurricanes ... 2-chloro-2-deoxyadenosine. 2-chlorodeoxyadenosine. Previous: ...
http://www.nci.nih.gov/Templates/drugdictionary.aspx?CdrID=41184
www.nci.nih.gov
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summary
Treatment of Langerhans cell histiocytosis with 2 chlorodeoxyadenosine.
1997 Mar;25(1-2):187-9. ... on the activity of 2 chlorodoxyadenosine in this disease, we ... 2 CdA appears to be effective in patients with resistant ...
http://www.ncbi.nlm.nih.gov/pubmed/9130627
www.ncbi.nlm.nih.gov
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summary
2-Chloro-2'-deoxyadenosine monophosphate residues in DNA enhance ...
Biochemical pharmacology of 2-chlorodeoxyadenosine in malignant human ... 2-Chlorodeoxyadenosine produces a high rate of complete hematologic remission in ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1137265
www.pubmedcentral.nih.gov
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Cladribine consumer information from Drugs.com
Cladribine patient information. ... Other commonly used names are 2-chlorodeoxyadenosine and 2-CdA . Category. Antineoplastic ...
http://www.drugs.com/cons/Cladribine.html
www.drugs.com
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summary
High complete remission rate in hairy cell leukemi...[Leuk Lymphoma ...
Weekly administration of 2-chlorodeoxyadenosine in patients with hairy-cell ... 2-chlorodeoxyadenosine (cladribine) in the treatment of hairy cell leukemia and ...
http://www.ncbi.nlm.nih.gov/pubmed/7907247
www.ncbi.nlm.nih.gov
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summary
Mycosis Fungoides and the Sézary Syndrome Treatment - National Cancer ...
Expert-reviewed information summary about the treatment of mycosis ... CJ, Carson DA, et al.: 2-Chlorodeoxyadenosine: an active agent in the treatment ...
http://www.nci.nih.gov/cancertopics/pdq/treatment/mycosisfun...
www.nci.nih.gov
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summary
eMedicine - Histiocytosis : Article by Cameron K Tebbi
Histiocytosis encompasses a group of diverse disorders with the common primary event of the accumulation and ... 2-chlorodeoxyadenosine (2CdA; ...
http://www.emedicine.com/ped/topic1997.htm
www.emedicine.com
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summary
Adult Non-Hodgkin's Lymphoma
In general, treatment with standard agents rarely produces a cure in patients ... activity for fludarabine and 2-chlorodeoxyadenosine has been demonstrated in ...
http://www.webmd.com/cancer/non-hodgkins-lymphoma/tc/ncicdr0...
www.webmd.com
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summary
Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2 ...
2-Chlorodeoxyadenosine (CdA) is active in chronic lymphocytic leukemia, hairy ... Potent toxicity of 2-chlorodeoxyadenosine toward human monocytes in vitro and in ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=48785
www.pubmedcentral.nih.gov
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summary
Treatment of hairy cell leukemia with cladribine (...[Ann Oncol. 2002 ...
2-chlorodeoxyadenosine (cladribine) in the treatment of hairy cell leukemia and ... Weekly administration of 2-chlorodeoxyadenosine in patients with hairy-cell ...
http://www.ncbi.nlm.nih.gov/pubmed/12377655
www.ncbi.nlm.nih.gov
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summary
Treatment of children with Langerhans cell histioc...[Am J Hematol ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE and ... 2-Chlorodeoxyadenosine (2-CDA) for ...
http://www.ncbi.nlm.nih.gov/pubmed/11891804
www.ncbi.nlm.nih.gov
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summary
Effects of 2-chloroadenine substitution in DNA on restriction ...
... of DNA synthesis by 2-chlorodeoxyadenosine in human lymphoblastic cells. ... 2-Chlorodeoxyadenosine: an effective new agent for the treatment of chronic ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=328283
www.pubmedcentral.nih.gov
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summary
Mycosis Fungoides and the Sézary Syndrome
Treatment options for patients with mycosis fungoides and the Sézary syndrome ... 2-chlorodeoxyadenosine; serotherapy with unlabeled, toxin-labeled, or ...
http://www.webmd.com/cancer/tc/mycosis-fungoides-and-the-sez...
www.webmd.com
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summary
Expression of deoxycytidine kinase and phosphorylation of 2 ...
... kinase and phosphorylation of 2-chlorodeoxyadenosine in human normal and tumour ... the recently developed antileukaemic compound 2-chlorodeoxyadenosine (CdA) ...
http://www.ncbi.nlm.nih.gov/pubmed/7718326
www.ncbi.nlm.nih.gov
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summary
eMedicine - Hypereosinophilic Syndrome : Article by Venkata Samavedi
... with damage to multiple organs.1, 2, 3, 4 Peripheral eosinophilia with tissue ... etoposide, vincristine, and 2-cda (2-chlorodeoxyadenosine) and cytarabine. ...
http://www.emedicine.com/MED/topic1076.htm
www.emedicine.com
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summary
Hairy Cell Leukemia with Unusual Loss of CD103 in a Subset of the ...
Clinical remission was achieved by treatment with 2-chlorodeoxyadenosine. ... leukemia-variant treated with 2-chlorodeoxyadenosine?a report of three cases. ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2480539
www.pubmedcentral.nih.gov
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summary
Chronic Lymphocytic Leukemia
Note: Some citations in the text of this section are followed by a level of evidence. ... Fludarabine, 2-chlorodeoxyadenosine, or pentostatin as seen in the CLB-9011 ...
http://www.webmd.com/cancer/tc/leukemia-chronic-lymphocytic-...
www.webmd.com
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summary
Wikipedia:WikiProject Pharmacology/List of drugs - Wikipedia, the free ...
2-chlorodeoxyadenosine. 2-PAM. 2-propylpentanoic acid. 2-propylvaleric acid. 2-pyridine aldoxime methochloride. 292 MEP. 311C90. 3M Avagard (Discontinued) ...
http://en.wikipedia.org/wiki/Wikipedia:WikiProject_Pharmacology/List_of_drugs
en.wikipedia.org
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summary
Successful treatment of Langerhans cell histiocyto...[Respirology. 2003 ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE and ... with 2-chlorodeoxyadenosine in ...
http://www.ncbi.nlm.nih.gov/pubmed/12856748
www.ncbi.nlm.nih.gov
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summary
Nausea and Vomiting - National Cancer Institute
Expert-reviewed information summary about nausea and vomiting as complications ... 2?5 episodes in 24 h; IV fluids ... 2-chlorodeoxyadenosine (Leustatin) ...
http://www.nci.nih.gov/cancertopics/pdq/supportivecare/nause...
www.nci.nih.gov
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summary
Rituximab in patients with hairy cell leukemia relapsing after ...
... cell leukemia relapsing after treatment with 2-chlorodeoxyadenosine (SAKK 31/98). Zenhäusern R, Simcock M, Gratwohl A, Hess U, Bargetzi M, Tobler A; Swiss Group ...
http://www.ncbi.nlm.nih.gov/pubmed/18603561?ordinalpos=1&ito...
www.ncbi.nlm.nih.gov
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summary
Mycosis Fungoides and the Sézary Syndrome
Note: Some citations in the text of this section are followed by a level of evidence. ... Fludarabine, 2-chlorodeoxyadenosine, and pentostatin are active agents for ...
http://www.webmd.com/cancer/tc/mycosis-fungoides-and-the-sez...
www.webmd.com
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summary
Hairy cell leukemia: A diagnosis by endoscopic ultrasound guided fine ...
... had been treated with 2-chlorodeoxyadenosine (2-Cda) therapy for the past four years. ... Figure 2 ... following 2-chlorodeoxyadenosine (2-Cda) therapy ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pub...
www.pubmedcentral.nih.gov
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summary
eMedicine - Neurosarcoidosis : Article by Gabriel Bucurescu
Sarcoidosis is a multisystem disease process whose pathogenesis involves ... was reported of treatment with antimetabolite cladribine (2-chlorodeoxyadenosine) ...
http://www.emedicine.com/NEURO/topic649.htm
www.emedicine.com
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summary
P53, MDM-2, BAX and BCL-2 and drug resistance in c...[Leuk Lymphoma ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE and ... of 2-chlorodeoxyadenosine activity by ...
http://www.ncbi.nlm.nih.gov/pubmed/9389352?ordinalpos=1&itoo...
www.ncbi.nlm.nih.gov
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summary
Treatment of Erdheim-Chester disease with cladribine: a rational approach
Potent toxicity of 2?chlorodeoxyadenosine towards human monocytes in vitro and ... of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1772168
www.pubmedcentral.nih.gov
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summary
[Treatment of hairy cell leukemia with cladribine] [Lijec Vjesn. 2007 ...
PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE and ... 2-chlorodeoxyadenosine (cladribine) ...
http://www.ncbi.nlm.nih.gov/pubmed/17557550
www.ncbi.nlm.nih.gov
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summary
Mycosis Fungoides and the Sézary Syndrome
The use of single alkylating agents has produced objective responses in 60% of ... Fludarabine, 2-chlorodeoxyadenosine, and pentostatin are active agents for ...
http://www.webmd.com/cancer/tc/mycosis-fungoides-and-the-sez...
www.webmd.com
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summary
2'DCF Drug Information, Professional
2'DCF Drug Information from Drugs.com. Includes 2'DCF side effects, interactions and indications. ... Pentostatin and 2-chlorodeoxyadenosine for hairy-cell leukemia. ...
http://www.drugs.com/mmx/2-dcf.html
www.drugs.com
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summary
Guidelines for Preventing Opportunistic Infections Among Hematopoietic ...
During the first >2 months after HSCT, recipients might experience acute GVHD ... or have recently received fludarabine or 2-chlorodeoxyadenosine (CDA) (CIII) ...
http://www.cdc.gov/MMWR/preview/MMWRhtml/rr4910a1.htm
www.cdc.gov
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summary
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