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what is 'thalassemia intermedia - genetic disease causing anemia by abnormal hemoglobin production '?
Definition for thalassemia intermedia
Thalassemia (American English) or thalassaemia (British English) is a dominant trait inherited disease of the red blood cells.
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Thalassemia (American English) or thalassaemia (British English) is a dominant trait inherited disease of the red blood cells. In thalassemia, the genetic defect results in reduced rate of synthesis of normal globin chains (c.f. hemoglobinopathy, which is a structural change in a globin chain leading to instability or abnormal oxygen transport). The blood cells are vulnerable to mechanical injury and die easily. Blood transfusions on a regular basis (two to three week intervals) are used by many patients to cope with the disease and maintain a healthier lifestyle than living with no treatment; bone marrow transplants can be performed if the transfusion's main side effect - build-up of iron - itself begins to be a problem. A bone marrow transplant requires careful matching to avoid rejection and further complications.
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do i have 'thalassemia intermedia'?
In addition the following diagnostic tests might be need to help verify the diagnosis:
diagnostic test search results for 'thalassemia intermedia'
1 - 5 of
29
diagnostic tests
Biopsy liver
thalassemia intermedia and Biopsy liver
Hemoglobin electrophoresis
thalassemia intermedia and Hemoglobin electrophoresis
Molecular Genetic Studies
thalassemia intermedia and Molecular Genetic Studies
Thyroid function tests
thalassemia intermedia and Thyroid function tests
globin gene analysis
thalassemia intermedia and globin gene analysis
CT liver
thalassemia intermedia and CT liver
Chest X-ray
Radiological technique to image the chest
thalassemia intermedia and Chest X-ray
Complete Blood Count
thalassemia intermedia and Complete Blood Count
ECHOcardiogram
thalassemia intermedia and ECHOcardiogram
EKG
Electrocardiogram
thalassemia intermedia and EKG
Fasting serum glucose
thalassemia intermedia and Fasting serum glucose
Liver Function Tests
elevated liver enzymes
thalassemia intermedia and Liver Function Tests
Peripheral blood smear
thalassemia intermedia and Peripheral blood smear
RBC distribution width (RDW)
thalassemia intermedia and RBC distribution width (RDW)
Reticulocyte count
thalassemia intermedia and Reticulocyte count
Serum Ferritin
thalassemia intermedia and Serum Ferritin
Serum transferrin saturation
thalassemia intermedia and Serum transferrin saturation
Skeletal radiograph survey
thalassemia intermedia and Skeletal radiograph survey
Serum Cortisol
thalassemia intermedia and Serum Cortisol
Blood, Platelet Count
Platelet Count
thalassemia intermedia and Blood, Platelet Count
Magnetic Resonance Imaging (MRI) Liver
thalassemia intermedia and Magnetic Resonance Imaging (MRI) Liver
ABO Blood Groups
thalassemia intermedia and ABO Blood Groups
CT scan
thalassemia intermedia and CT scan
Fetal hemoglobin (HbF)
thalassemia intermedia and Fetal hemoglobin (HbF)
Iron indices
thalassemia intermedia and Iron indices
Serum iron
thalassemia intermedia and Serum iron
Serum transferrin saturation
thalassemia intermedia and Serum transferrin saturation
serum total iron binding capacity (TIBC)
thalassemia intermedia and serum total iron binding capacity (TIBC)
serum total iron binding capacity (TIBC)
thalassemia intermedia and serum total iron binding capacity (TIBC)
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therapeutic procedures for 'thalassemia intermedia'?
Managing or treating a diseases should always be determined by a patients health care provider. Below is a list of associated therapeutic procedures or medications for thalassemia intermedia:
therapeutic procedure search results for 'thalassemia intermedia'
1 - 5 of
9
therapeutic procedures
rankings are computer generated. please consult your health care provider.
Blood Transfusion
Transfusion of blood through a vein
thalassemia intermedia and Blood Transfusion
Splenectomy
thalassemia intermedia and Splenectomy
ABO Blood Groups
thalassemia intermedia and ABO Blood Groups
Bone Marrow Transplant
thalassemia intermedia and Bone Marrow Transplant
Chelation Therapy
thalassemia intermedia and Chelation Therapy
Histocompatibility testing
thalassemia intermedia and Histocompatibility testing
Hypertransfusion
thalassemia intermedia and Hypertransfusion
Packed red blood cell Transfusion
thalassemia intermedia and Packed red blood cell Transfusion
long-term transfusion therapy
thalassemia intermedia and long-term transfusion therapy
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medications search results for 'thalassemia intermedia'
1 - 5 of
9
medications
rankings are computer generated. please consult your health care provider.
Vitamin E
thalassemia intermedia and Vitamin E
folic acid
thalassemia intermedia and folic acid
Deferasirox
thalassemia intermedia and Deferasirox
Ascorbic acid
thalassemia intermedia and Ascorbic acid
Deferoxamine mesylate
thalassemia intermedia and Deferoxamine mesylate
Pneumococcal vaccine/PS23
thalassemia intermedia and Pneumococcal vaccine/PS23
Meningococcal vaccine
thalassemia intermedia and Meningococcal vaccine
Haemophilus influenzae b conjugate vaccine
thalassemia intermedia and Haemophilus influenzae b conjugate vaccine
Pneumococcal 7-valent conjugate vaccine
thalassemia intermedia and Pneumococcal 7-valent conjugate vaccine
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web search results for 'thalassemia intermedia'?
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1 - 50
- thalassemia intermedia
Quality of life in patients with thalassemia intermedia compared to ...
... life in patients with thalassemia intermedia compared to thalassemia major. ... The impact of thalassemia major and thalassemia intermedia and their associated ...
http://www.ncbi.nlm.nih.gov/pubmed/16339697?dopt=Abstract
www.ncbi.nlm.nih.gov
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summary
Multicenter study of the molecular basis of thalassemia intermedia in ...
We studied 325 thalassemia intermedia patients from Iran, India, Pakistan, ... that in cases of thalassemia intermedia with beta(+) mutations, the common ...
http://www.ncbi.nlm.nih.gov/pubmed/17994378
www.ncbi.nlm.nih.gov
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Beta-thalassemia intermedia due to two novel mutations in the promoter ...
Beta-thalassemia intermedia due to two novel mutations in the promoter region of ... beta-thalassemia intermedia in association with a beta(0)-thalassemia mutations. ...
http://www.ncbi.nlm.nih.gov/pubmed/18081706?ordinalpos=2&ito...
www.ncbi.nlm.nih.gov
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summary
b-thalassemia intermedia resulting from compound heterozigosity for an ...
b-thalassemia intermedia resulting from compound ... beta-Thalassemia/genetics* beta-Thalassemia/therapy. PMID: 10756381 [PubMed - indexed for MEDLINE] ...
http://www.ncbi.nlm.nih.gov/pubmed/10756381
www.ncbi.nlm.nih.gov
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Thalassemia-Topic Overview
Thalassemia is an inherited blood disorder that causes the body to produce less ... People who have beta thalassemia intermedia usually live into adulthood. ...
http://www.webmd.com/a-to-z-guides/thalassemia-topic-overview
www.webmd.com
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Pictorial CME. beta Thalassemia intermedia.
1: J Assoc Physicians India. 1997 Nov;45(11):865. Pictorial CME. beta Thalassemia intermedia. Kulkarni V, Kamath S, Bichile SK. ...
http://www.ncbi.nlm.nih.gov/pubmed/11229188
www.ncbi.nlm.nih.gov
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[Molecular diagnosis of beta-thalassemia intermedia]
... To analyze the molecular abnormalities of beta-thalassemia intermedia and ... 14 patients with beta-thalassemia intermedia, we analyzed the hematologies, ...
http://www.ncbi.nlm.nih.gov/pubmed/9772460
www.ncbi.nlm.nih.gov
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Thalassemia - Wikipedia, the free encyclopedia
In thalassemia, the genetic defect results in reduced rate of synthesis of one ... of India; clinically similar to ? thalassemia major or thalassemia intermedia. ...
http://en.wikipedia.org/wiki/Thalassemia
en.wikipedia.org
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Beta thalassemia - Genetics Home Reference
Signs and symptoms of thalassemia intermedia appear in early childhood or later in life. Individuals with thalassemia intermedia have mild to moderate anemia and may ...
http://ghr.nlm.nih.gov/condition=betathalassemia
ghr.nlm.nih.gov
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Thalassemia - Topic Overview - Yahoo! Health
Alpha thalassemia and beta thalassemia are the two main types of the disease. ... People who have beta thalassemia intermedia usually live into adulthood. ...
http://health.yahoo.com/blood-overview/thalassemia-topic-ove...
health.yahoo.com
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BETA THALASSEMIA - Pedbase.org
Intermedia - 2 beta-thalassemia genes ... 1. Thalassemia Intermedia. 2-10% of ... 2. Thalassemia Major. also called Cooley anemia, Mediterranean anemia, or ...
http://pedbase.org/t/thalassemia_beta-thalassemia/
pedbase.org
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Entrez Gene HBB - GeneRIFs - Genetics Home Reference
Adekile A, Haider M, Kutlar F. Mutations associated with beta-thalassemia intermedia in Kuwait. ... N, Badens C. Beta-thalassemia intermedia due to two novel ...
http://ghr.nlm.nih.gov/ghr/locuslink/3043/show/GeneRIFs
ghr.nlm.nih.gov
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Division of Pathology and Laboratory Medicine Publications, 2003
high-grade prostatic intraepithelial neoplasia from prostatic ... delivery in a patient with Beta thalassemia intermedia. Anesth Analg 2003 Dec;97(6):1808 ...
http://www.clevelandclinic.org/pathology/uploads/2003%20Comp...
www.clevelandclinic.org
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Orphanet: Hemoglobin C disease
The portal for rare diseases ... beta thalassemia, especially with beta+thalassemia (more common ... and can exceptionally mimic beta thalassemia intermedia. ...
http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=2132
www.orpha.net
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delta beta Thalassemia(F thalassaemia) - NextBio
... beta thalassaemia major beta thalassemia beta thalassemia intermedia beta ... thalassaemia intermedia thalassaemia major thalassemia intermedia thalassemias ...
http://www.nextbio.com/b/home/home.nb?q=F+thalassaemia&id=13...
www.nextbio.com
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Beta thalassemia - References - Genetics Home Reference
OMIM: Beta Thalassemia, Dominant Inclusion Body Type ... Rachmilewitz E. Beta-thalassemia. N Engl J ... Thalassemia intermedia: revisited. Blood Cells Mol Dis. ...
http://ghr.nlm.nih.gov/condition=betathalassemia/show/References
ghr.nlm.nih.gov
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delta beta Thalassemia(F thalassemia) - NextBio
... thalassemia thalassemia intermedia thalassemia major ... molecular basis for beta thalassemia intermedia poses new questions about its pathophysiology. ...
http://www.nextbio.com/b/home/home.nb?q=F+thalassemia&id=137...
www.nextbio.com
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Beta-Thalassemia -- GeneReviews -- NCBI Bookshelf
Individuals with thalassemia intermedia present later and have milder anemia ... ?-thalassemia intermedia. ... Thalassemia intermedia. ...
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=b-thal
www.ncbi.nlm.nih.gov
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Statistique d'Usage du Serveur Orphanet orphanet.orpha.net - Aout 2007 ...
Période du résumé: Aout 2007 - Mots-clés. Généré le 01-Sep-2007 23:17 CEST. Hits Mots-clés -444 0.33% dermatomiositis 413 0.31% adrenoleucodistrofia 376 ...
http://orphanet.orpha.net/stat/orphanet/search_200708.html
orphanet.orpha.net
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Beta-Thalassemia
Individuals with thalassemia intermedia ... Thalassemia intermedia: symptomatic ... Thalassemia intermedia is suspected in individuals who present at a later ...
http://www.ncbi.nlm.nih.gov/bookshelf/picrender.fcgi?book=ge...
www.ncbi.nlm.nih.gov
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Entrez Gene SLC40A1 - GeneRIFs - Genetics Home Reference
Altčs A, Bach V, Ruiz A, Esteve A, Remacha AF, Sardā MP, Felez J, ... on iron overload in Greek thalassemia intermedia and beta(s)/beta(thal) anemia patients. ...
http://ghr.nlm.nih.gov/ghr/locuslink/30061/show/GeneRIFs
ghr.nlm.nih.gov
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Hbg Ferrara(HB G Ferrara) - NextBio
Cardiac involvement in beta-thalassemia major and beta-thalassemia intermedia. ... intermedia and thalassemia major by M-mode, bi-dimensional echocardiography ...
http://www.nextbio.com/b/home/home.nb?q=HB+G+Ferrara&id=8061...
www.nextbio.com
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Prevalence of thrombotic risk factors among beta-thalassemia patients ...
... profiles in beta-thalassemia major and intermedia patients from Western Iran. ... old boy with beta-thalassemia intermedia receiving regularly blood transfusion ...
http://www.ncbi.nlm.nih.gov/pubmed/17982733
www.ncbi.nlm.nih.gov
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Entrez Gene HFE - GeneRIFs - Genetics Home Reference
Adams LA, Angulo P, Abraham SC, Torgerson H, Brandhagen D. The ... on iron overload in Greek thalassemia intermedia and beta(s)/beta(thal) anemia patients. ...
http://ghr.nlm.nih.gov/ghr/locuslink/3077/show/GeneRIFs
ghr.nlm.nih.gov
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Hemoglobin Malay(Hb Malay) - NextBio
Molecular characterization of thalassemia intermedia with homozygous Hb Malay ... beta-thalassemia intermedia caused by compound heterozygosity for Hb Malay (beta ...
http://www.nextbio.com/b/home/home.nb?q=Hb+Malay&id=8093838&...
www.nextbio.com
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Thalassemia.
Improved survival of patients with thalassemia has given new importance to adult ... major and thalassemia intermedia, and pulmonary hypertension is now the focus of ...
http://www.ncbi.nlm.nih.gov/pubmed/15561674
www.ncbi.nlm.nih.gov
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G Fiorelli - NextBio
... thalassaemia intermedia beta thalassemia beta thalassemia intermedia cell ... Exercise capacity in patients with beta-thalassaemia intermedia. ...
http://www.nextbio.com/b/literature/literature.nb?author=G+Fiorelli
www.nextbio.com
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Anemia in beta-thalassemia patients targets hepatic hepcidin transcript ...
... expression in 10 thalassemia major and 13 thalassemia intermedia patients. ... were decreased in the thalassemia intermedia group which presented both lower ...
http://www.ncbi.nlm.nih.gov/pubmed/18166793?ordinalpos=2&ito...
www.ncbi.nlm.nih.gov
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Hemoglobin Dhonburi alpha 2 beta 2 126 (H4) Val----Gly: a new unstable ...
... beta-thalassemia intermedia phenotype in association with beta zero-thalassemia. ... the mechanism of a beta-thalassemia intermedia phenotype in a 34 year ...
http://www.ncbi.nlm.nih.gov/pubmed/2399911
www.ncbi.nlm.nih.gov
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Alpha and Beta Thalassemia Causes, Symptoms, Treatment and Diagnosis on ...
Read about thalassemias (alpha, beta), inherited blood disorders with symptoms such as anemia, slowed growth, ... have beta thalassemia intermedia or beta ...
http://www.medicinenet.com/alpha_thalassemia/page3.htm
www.medicinenet.com
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PMID 10926923
Thalassemia, in contrast, results from quantitative reductions in globin ... Thalassemia intermedia (i.e., Hb H disease) is typified by a moderate, variably ...
http://www.ncbi.nlm.nih.gov/pubmed/10926923
www.ncbi.nlm.nih.gov
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summary
A novel beta-globin structural mutant, Hb Brescia (beta 114 Leu-Pro ...
... (beta 114 Leu-Pro), causing a severe beta-thalassemia intermedia phenotype. ... describes a patient with a thalassemia intermedia-like phenotype in whom beta ...
http://www.ncbi.nlm.nih.gov/pubmed/1301199
www.ncbi.nlm.nih.gov
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Agamma delta beta0 Thalassemia(A gamma delta beta0 Thalassaemia) - NextBio
... thalassemia beta thalassaemia beta thalassemia beta thalassemia intermedia beta ... disease to a beta-thalassemia intermedia phenotype and to look for the ...
http://www.nextbio.com/b/home/home.nb?q=A+gamma+delta+beta0+...
www.nextbio.com
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Abstract
... 0006-4971 109 11 2007 Jun 1 Blood Ineffective erythropoiesis in beta-thalassemia ... consistent with both beta-thalassemia intermedia (th3/+) and major (th3/th3) ...
http://www.ncbi.nlm.nih.gov/pubmed/17299088?ordinalpos=1&ito...
www.ncbi.nlm.nih.gov
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Am J Hematol . 2008 Jan 7
Response to hydroxyurea therapy in beta-thalassemia. ... Five thalassemia intermedia (TI) patients receiving occasional blood transfusion ...
http://www.ncbi.nlm.nih.gov/pubmed/18181203?ordinalpos=1&ito...
www.ncbi.nlm.nih.gov
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Acquired pseudoxanthoma elasticum - NextBio
... arteriosclerotic encephalopathy thalassemia intermedia unstable angina ... Loss of vision associated with angioid streaks in beta-thalassemia intermedia. ...
http://www.nextbio.com/b/home/home.nb?q=Acquired+pseudoxanth...
www.nextbio.com
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Thalassemia-Treatment Overview
Treatment for thalassemia depends on the severity of the condition. ... Moderate thalassemia (thalassemia intermedia and more severe hemoglobin H ...
http://www.webmd.com/a-to-z-guides/thalassemia-treatment-overview
www.webmd.com
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Standardized T2* map of a normal human heart to correct T2* segmental ...
... in thalassemia intermedia versus thalassemia major patients and ... thalassemia major (TM) and thalassemia intermedia (TI) patients and of ...
http://www.ncbi.nlm.nih.gov/pubmed/18274987
www.ncbi.nlm.nih.gov
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Genetic modifiers in hemoglobinopathies.
In thalassemia major or intermedia, reduction in the number of alpha globin ... convert beta thalassemia trait to a clinical picture of thalassemia intermedia. ...
http://www.ncbi.nlm.nih.gov/pubmed/18991646?ordinalpos=42&it...
www.ncbi.nlm.nih.gov
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Hemoglobin Bart's hydrops syndrome(Alpha thalassemia major) - NextBio
... thalassaemias beta thalassemia beta thalassemia intermedia beta-globin chronic ... Current status of thalassemia in minority populations in Guangxi, China. ...
http://www.nextbio.com/b/home/home.nb?q=Alpha+thalassemia+ma...
www.nextbio.com
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PMID 2018842
... 28 2008 11 21 0006-4971 77 9 1991 May 1 Blood Thalassemia intermedia: moderate ... A patient with homozygous beta thalassemia of German/Italian descent was ...
http://www.ncbi.nlm.nih.gov/pubmed/2018842
www.ncbi.nlm.nih.gov
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CDC Funding and Procurement
A thalassemia treatment center is defined as a specialty, prevention, diagnostic ... thalassemia major, beta thalassemia intermedia, Hemoglobin H (Hb H) disease, Hb ...
http://www.cdc.gov/od/pgo/funding/DD07-011.htm
www.cdc.gov
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2801854 1989 11 09 1989 11 09 2004 11 17 0002-9394 108 4 1989 Oct 15 Am ...
... and 38 had beta thalassemia intermedia) were examined by ophthalmoscopy for angioid streaks. ... thalassemia major and beta thalassemia intermedia groups ...
http://www.ncbi.nlm.nih.gov/pubmed/2801854
www.ncbi.nlm.nih.gov
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Hemoglobin E/beta thalassemia disease(Haemoglobin E/beta thalassaemia ...
... thalassaemia intermedia beta thalassaemia major beta thalassemia bilirubin bone ... Reticulocyte severity disease sodium SRI thalassaemia thalassemia intermedia ...
http://www.nextbio.com/b/home/home.nb?q=Haemoglobin+E%2Fbeta...
www.nextbio.com
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Genotype-phenotype correlations in beta-thalassemias.
... we review the molecular basis of the marked heterogeneity of the thalassemia ... attenuated forms of thalassemia syndromes referred to as thalassemia intermedia. ...
http://www.ncbi.nlm.nih.gov/pubmed/8205005?ordinalpos=311&it...
www.ncbi.nlm.nih.gov
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Hb Brescia - NextBio
... (beta 114 Leu-Pro), causing a severe beta-thalassemia intermedia phenotype. ... describes a patient with a thalassemia intermedia-like phenotype in whom beta ...
http://www.nextbio.com/b/home/home.nb?q=Hb+Brescia&id=809804...
www.nextbio.com
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Hemoglobin E
trimester in women with ? thalassemia intermedia, to reduce anemia and low weight ... minor through thalassemia intermedia to. thalassemia major. Most patients ...
http://www.orpha.net/data/patho/GB/uk-HbE.pdf
www.orpha.net
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DM Albuquerque - NextBio
... anemia Asn beta thalassemia beta thalassemia intermedia beta-globin bone marrow ... sickle cell anaemia sickle cell anemia TCF12 thalassemia intermedia TP53 TYR ...
http://www.nextbio.com/b/literature/literature.nb?author=DM+Albuquerque
www.nextbio.com
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Alpha-Thalassemia -- GeneReviews -- NCBI Bookshelf
Alphaš-thalassemia results from deletion or dysfunction of two alleles, and ? ... heterozygous ?-thalassemia results in a mild thalassemia intermedia phenotype. ...
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=a-thal
www.ncbi.nlm.nih.gov
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M Saghafi - NextBio
... chest wall beta thalassemia intermedia bone marrow brain ... Extramedullary hematopoiesis with spinal cord compression in beta-thalassemia intermedia. ...
http://www.nextbio.com/b/literature/literature.nb?author=M+Saghafi
www.nextbio.com
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quick facts
category
genetic or congenital
hematological
frequency
uncommon (U.S.)
likelihood by age
likelyhood by duration of symptoms
some common symptoms
anemia
dizziness
fatigue
paleness
some related diagnoses
anemia
iron deficiency anemia
Von Willebrand's disease
drugs and toxins
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hematologist
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