paroxysmal cold hemoglobinuria - destruction of red blood cells with cold exposure - MEDgle - On-Demand Clinical Case Analysis for Patients and Health Professionals - search your symptoms, diagnoses, drugs, procedures

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hematological
frequency
rare (U.S.) Usually seen in children.

likelihood by age

likelyhood by duration of symptoms

related physician types

hematologist
family practitioner
internist

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paroxysmal cold hemoglobinuria - destruction of red blood cells with cold exposure

Paroxysmal cold hemoglobinuria (PCH) (also known as Donath-Landsteiner syndrome) is a disease of humans that is characterized by the sudden presence of hemoglobin in the urine (called hemoglobinuria), typically after exposure to cold temperatures.

In people with PCH, a polyclonal IgG autoantibody binds to red blood cell surface antigens in the cold. This can occur in a susceptible individual as blood passes through cold extremities in cold weather. When the blood returns to the warmer central circulation, the red blood cells are lysed with complement, causing intravascular hemolysis. Hemoglobinuria and anemia can then occur. The anemia may be mild or severe. less

some common symptoms
dark urine muscle cramps rash yellow color of skin and eyes

some related diagnoses

1 - 7 of 51 diagnoses
	drugs and toxins

	G6PD deficiency

	hemolytic anemia

	hereditary spherocytosis

	cytomegalovirus

	autoimmune hemolytic anemia

	acute viral hepatitis

	more

diagnostic test search results for 'paroxysmal cold hemoglobinuria'

1 - 5 of 31 diagnostic tests

	CMV serology	paroxysmal cold hemoglobinuria and CMV serology
	Coombs test	paroxysmal cold hemoglobinuria and Coombs test
	Donath-Landsteiner IgG autoantibody	paroxysmal cold hemoglobinuria and Donath-Landsteiner IgG autoantibody
	Epstein Barr Virus serology	paroxysmal cold hemoglobinuria and Epstein Barr Virus serology
	Indirect Coombs' test	paroxysmal cold hemoglobinuria and Indirect Coombs' test
	Mumps serology	paroxysmal cold hemoglobinuria and Mumps serology
	Mycoplasma serology	paroxysmal cold hemoglobinuria and Mycoplasma serology
	RPR (rapid plasma reagin)	paroxysmal cold hemoglobinuria and RPR (rapid plasma reagin)
	influenza serology	paroxysmal cold hemoglobinuria and influenza serology
	measles serology	paroxysmal cold hemoglobinuria and measles serology
	varicella-zoster virus serology	paroxysmal cold hemoglobinuria and varicella-zoster virus serology
	Complement levels	paroxysmal cold hemoglobinuria and Complement levels
	Complete Blood Count	paroxysmal cold hemoglobinuria and Complete Blood Count
	Lactate dehydrogenase (LDH)	paroxysmal cold hemoglobinuria and Lactate dehydrogenase (LDH)
	Peripheral blood smear	paroxysmal cold hemoglobinuria and Peripheral blood smear
	Reticulocyte count	paroxysmal cold hemoglobinuria and Reticulocyte count
	Serum haptoglobin	paroxysmal cold hemoglobinuria and Serum haptoglobin
	Total bilirubin	paroxysmal cold hemoglobinuria and Total bilirubin
	Urinalysis	Examination of urine to detect disease paroxysmal cold hemoglobinuria and Urinalysis
	Urinary Hemoglobin	paroxysmal cold hemoglobinuria and Urinary Hemoglobin
	direct bilirubin	paroxysmal cold hemoglobinuria and direct bilirubin
	urinary hemosiderin	paroxysmal cold hemoglobinuria and urinary hemosiderin
	adenovirus serology	paroxysmal cold hemoglobinuria and adenovirus serology
	ABO Blood Groups	paroxysmal cold hemoglobinuria and ABO Blood Groups
	BUN	paroxysmal cold hemoglobinuria and BUN
	Blood, Platelet Count	Platelet Count paroxysmal cold hemoglobinuria and Blood, Platelet Count
	Serum Creatinine	paroxysmal cold hemoglobinuria and Serum Creatinine
	Blood Type and Crossmatch	paroxysmal cold hemoglobinuria and Blood Type and Crossmatch
	Direct Coombs Test	paroxysmal cold hemoglobinuria and Direct Coombs Test
	Intravenous (IV) lactated Ringer (LR) solution	paroxysmal cold hemoglobinuria and Intravenous (IV) lactated Ringer (LR) solution
	urinary urobilinogen	paroxysmal cold hemoglobinuria and urinary urobilinogen
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therapeutic procedure search results for 'paroxysmal cold hemoglobinuria'
1 - 5 of 7 therapeutic procedures
rankings are computer generated. please consult your health care provider.

	Splenectomy	paroxysmal cold hemoglobinuria and Splenectomy
	ABO Blood Groups	paroxysmal cold hemoglobinuria and ABO Blood Groups
	Blood Transfusion	Transfusion of blood through a vein paroxysmal cold hemoglobinuria and Blood Transfusion
	Blood Type and Crossmatch	paroxysmal cold hemoglobinuria and Blood Type and Crossmatch
	Intravenous (IV) fluids	paroxysmal cold hemoglobinuria and Intravenous (IV) fluids
	Intravenous (IV) normal saline (NS)	paroxysmal cold hemoglobinuria and Intravenous (IV) normal saline (NS)
	Packed red blood cell Transfusion	paroxysmal cold hemoglobinuria and Packed red blood cell Transfusion
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medications search results for 'paroxysmal cold hemoglobinuria'
1 - 1 of 1 medications
rankings are computer generated. please consult your health care provider.

Prednisone

paroxysmal cold hemoglobinuria and Prednisone

web search results for paroxysmal cold hemoglobinuria