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sly syndrome - accumulation of complex carbodydrates in cells; MPS Type V11
Definition for Sly Syndrome
Mucopolysaccharidosis Type VII or Sly syndrome (named after its discoverer William Sly in 1969) is also sometimes called MPS.
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Mucopolysaccharidosis Type VII or Sly syndrome (named after its discoverer William Sly in 1969) is also sometimes called MPS. The defective gene lies on chromosome 7. MPS is transmitted as an autosomal recessive trait.
It is an extremely rare inherited metabolic disorder characterized by a deficiency of the enzyme β-glucuronidase, a lysosomal enzyme. Sly syndrome belongs to a group of disorders known as the mucopolysaccharidoses, which are lysosomal storage diseases. In Sly syndrome, the deficiency in β-glucuronidase leads to the accumulation of certain complex carbohydrates (mucopolysaccharides) in many tissues and organs of the body.
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some common symptoms
delayed development
enlarged liver
face deformities
stomach swelling
some related diagnoses
1 - 7 of
14
diagnoses
common variable immunodeficiency
human immunodeficiency virus infections
malnutrition
neurofibromatosis type 1
myopathies
Immune Deficiency
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do i have 'Sly Syndrome'?
In addition the following diagnostic tests might be need to help verify the diagnosis:
diagnostic test search results for 'sly syndrome'
1 - 5 of
22
diagnostic tests
CT Cervical Spine
Sly Syndrome and CT Cervical Spine
Granulocyte exam for coarse metachromatic inclusions
Sly Syndrome and Granulocyte exam for coarse metachromatic inclusions
X-ray skull
Sly Syndrome and X-ray skull
X-rays
Sly Syndrome and X-rays
Amniocentesis
Sly Syndrome and Amniocentesis
b-glucuronidase in cultured skin fibroblasts
Sly Syndrome and b-glucuronidase in cultured skin fibroblasts
b-glucuronidase in white blood cells
Sly Syndrome and b-glucuronidase in white blood cells
Chorionic Villus Sampling (CVS)
Sly Syndrome and Chorionic Villus Sampling (CVS)
24 hour urinary acid mucopolysaccharides
Sly Syndrome and 24 hour urinary acid mucopolysaccharides
CT scan
Sly Syndrome and CT scan
Cervical radiography
Sly Syndrome and Cervical radiography
Developmental testing
Sly Syndrome and Developmental testing
Lysosomal enzymes
Sly Syndrome and Lysosomal enzymes
Molecular Genetic Studies
Sly Syndrome and Molecular Genetic Studies
Urine glycosaminoglycan
Sly Syndrome and Urine glycosaminoglycan
Urine spot tests for mucopolysaccharides (GAG)
Sly Syndrome and Urine spot tests for mucopolysaccharides (GAG)
cultured skin fibroblasts for biochemical study
Sly Syndrome and cultured skin fibroblasts for biochemical study
direct enzymatic assay in white blood cells
Sly Syndrome and direct enzymatic assay in white blood cells
urine chondroitin 4 6 sulphate
Sly Syndrome and urine chondroitin 4 6 sulphate
urine dermatan sulfate
Sly Syndrome and urine dermatan sulfate
urine dimethylmethylene blue test
Sly Syndrome and urine dimethylmethylene blue test
urine heparan sulfate
Sly Syndrome and urine heparan sulfate
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therapeutic procedures for 'Sly Syndrome'?
Managing or treating a diseases should always be determined by a patients health care provider. Below is a list of associated therapeutic procedures or medications for Sly Syndrome:
therapeutic procedure search results for 'sly syndrome'
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therapeutic procedures
rankings are computer generated. please consult your health care provider.
Hematopoietic stem cell transplantation
Sly Syndrome and Hematopoietic stem cell transplantation
Histocompatibility testing
Sly Syndrome and Histocompatibility testing
medications search results for 'sly syndrome'
rankings are computer generated. please consult your health care provider.
web search results for sly syndrome
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- Sly Syndrome
Sly Syndrome - Yahoo! Health
Important It is possible that the main title of the report Sly Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name ...
http://health.yahoo.com/other-other/sly-syndrome/healthwise--nord291.html
health.yahoo.com
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Sly syndrome - Wikipedia, the free encyclopedia
In Sly syndrome, the deficiency in ?-glucuronidase leads to the accumulation of ... is a charity that is trying to raise money to find treatment for Sly syndrome. ...
http://en.wikipedia.org/wiki/Sly_syndrome
en.wikipedia.org
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SLY SYNDROME - Pedbase.org
PEDBASE.org - The Pediatric Database - Detailed information of SLY SYNDROME. SLY SYNDROME ... 1994 -2007 Pedbase.org. Powered by Database of Pediatrics- SLY SYNDROME ...
http://pedbase.org/s/sly-syndrome/
pedbase.org
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Four novel mutations in mucopolysaccharidosis type VII including a ...
... type VII (MPS VII), or Sly syndrome, is a lysosomal storage disorder caused ... evidence for the broad molecular heterogeneity in Sly syndrome. Mesh Terms: ...
http://www.ncbi.nlm.nih.gov/pubmed/7633414
www.ncbi.nlm.nih.gov
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WebMD Health A-Z - Find reliable health and medical information on ...
Find a comprehensive index of trusted health and medical information. It is your ultimate guide to ... Sly Syndrome. SMA. SMA 1. SMA I. SMA III. SMA, ...
http://www.webmd.com/a-to-z-guides/health-topics/sk-so.htm
www.webmd.com
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medical terms, dictionary and encyclopedia
... acute respiratory syndrome. Severe combined immunodeficiency ... Sly syndrome. Back to Top. Sm-Sn. SMA. Smad3. SMAD4. SMAD4/DPC4. Small bowel. Small calorie ...
http://www.medicinenet.com/htmlalphaidx/dict_S.htm
www.medicinenet.com
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Encyclopedia S-Sz on Yahoo! Health
Health encyclopedia of diseases and conditions covering symptoms, definitions, alternative names, causes, ... Sly Syndrome. Small intestine cancer: ...
http://health.yahoo.com/ency/s/
health.yahoo.com
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Correction of murine mucopolysaccharidosis VII by a human beta ...
Kyle JW, Birkenmeier EH, Gwynn B, Vogler C, Hoppe PC, Hoffmann JW, Sly WS. ... mucopolysaccharidosis VII (Sly syndrome) and are shown here to have secondary ...
http://www.ncbi.nlm.nih.gov/pubmed/2111021?dopt=Abstract
www.ncbi.nlm.nih.gov
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PMID 8348154
Correction of lysosomal storage in the liver and spleen of MPS VII mice by ... a disease homologous to human mucopolysaccharidosis type VII (Sly syndrome) ...
http://www.ncbi.nlm.nih.gov/pubmed/8348154
www.ncbi.nlm.nih.gov
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Mucopolysaccharidoses - Yahoo! Health
Important It is possible that the main title of the report Mucopolysaccharidoses ... MPS VII (Sly Syndrome) MPS VIII (obsolete) MPS II-(Hunter Syndrome) ...
http://health.yahoo.com/digestive-overview/mucopolysaccharid...
health.yahoo.com
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Genomics|HuGENet|Fact sheets|FMR1 and the Fragile X Syndrome
The mission of the National Office of Public Health Genomics is to integrate advances in human genetics into ... C, Beaudet A, Sly W, Valle D, editors. ...
http://www.cdc.gov/genomics/hugenet/factsheets/FS_FragileX.htm
www.cdc.gov
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Kaufman oculocerebrofacial syndrome - Wikipedia, the free encyclopedia
Kaufman R, Rimoin D, Prensky A, Sly W (1971). " An oculocerebrofacial syndrome. ... Kaufman oculocerebrofacial syndrome at NIH's Office of Rare Diseases ...
http://en.wikipedia.org/wiki/Kaufman_oculocerebrofacial_syndrome
en.wikipedia.org
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Site Map od Pedbase.org - The Pediatric Database
Pedbase Site Map. Pediatric. Site Map. Resources. Contact. PEDBASE.org - The Pediatric Database. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. R. S. T. U. V. W. X ...
http://pedbase.org/sitemap.html
pedbase.org
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253220
http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=253220
www.ncbi.nlm.nih.gov
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Hurler Syndrome - Wikipedia
User-edited article about the genetic disorder Hurler Syndrome.
http://en.wikipedia.org/wiki/Hurler_Syndrome
en.wikipedia.org
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Genomics|HuGENet|Reviews|References|FMR1 and the Fragile X Syndrome ...
The mission of the National Office of Public Health Genomics is to integrate advances ... The fragile X syndrome. In: Scriver CR, Beaudet AL, Sly WS, editors. ...
http://www.cdc.gov/genomics/hugenet/reviews/tables/FragileX_Ref.htm
www.cdc.gov
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Morquio syndrome - Wikipedia, the free encyclopedia
Morquio's syndrome (referred to as mucopolysaccharidosis IV or ... 1:Hurler/Scheie ˇ 2:Hunter ˇ 3:Sanfilippo ABCD ˇ 4:Morquio ˇ 6:Maroteaux-Lamy ˇ 7:Sly ...
http://en.wikipedia.org/wiki/Morquio_syndrome
en.wikipedia.org
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An oculocerebrofacial syndrome.
... Artic Ser. 1971 Feb;7(1):135-8. An oculocerebrofacial syndrome. ... RL, Rimoin DL, Prensky AL, Sly WS. A syndrome of mental retardation, microcephaly, a ...
http://www.ncbi.nlm.nih.gov/pubmed/5006210
www.ncbi.nlm.nih.gov
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Stanley Jablonski: 1976-2004- Retirement
"Syndrome ? le mot de jour" in Bulletin of the Medical Library Association (1991) ... Displaying a sly sense of humor, Stanley slipped these two imaginary syndromes ...
http://www.nlm.nih.gov/hmd/jablonski/retirement.html
www.nlm.nih.gov
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Birt-Hogg-Dubé Syndrome -- GeneReviews -- NCBI Bookshelf
Hornstein-Knickenberg syndrome (HK), which describes familial multiple ... In: Scriver CR, Beaudet AL, Sly WS, Valle D, Vogelstein B (eds) The Metabolic ...
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=bhd
www.ncbi.nlm.nih.gov
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Crigler-Najjar syndrome - Wikipedia, the free encyclopedia
Explains this rare disorder, including the two types, diagnosis, experimental ... metabolism.In: Scriver, C. R.; Beaudet, A. L.; Sly, W. S.; Valle, D. (eds. ...
http://en.wikipedia.org/wiki/Crigler-Najjar_syndrome
en.wikipedia.org
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Kallmann Syndrome -- GeneReviews -- NCBI Bookshelf
Kallmann syndrome 1 (KS1), caused by mutations in KAL1, is inherited in an ... In: Scriver CR, Beaudet AL, Sly WS, Valle D, Vogelstein B (eds) The Metabolic ...
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=kms
www.ncbi.nlm.nih.gov
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Genomics|Training|Books|HuGE|Part 4, Chapter 23
The fragile X syndrome, an X-linked dominant disorder with reduced penetrance, ... In: Scriver CR, Beaudet AL, Sly WS, editors. ...
http://www.cdc.gov/genomics/training/books/huge/chap23.htm
www.cdc.gov
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Sanfilippo Syndrome - Wikipedia
User-edited article about the rare genetic disease Sanfilippo Syndrome.
http://en.wikipedia.org/wiki/Sanfilippo_syndrome
en.wikipedia.org
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Marfan Syndrome -- GeneReviews -- NCBI Bookshelf
Marfan syndrome is inherited in an autosomal dominant manner. ... In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The Metabolic and Molecular ...
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=marfan
www.ncbi.nlm.nih.gov
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Human Streptococcus suis Outbreak, China | CDC EID
Sixty-one (28%) of the farmers had streptococcal toxic shock syndrome; 38 (62%) of them died. ... These isolates (mrp+, ef+, sly+) are related to European ...
http://www.cdc.gov/ncidod/eid/vol12no06/05-1194.htm
www.cdc.gov
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Reiter's Disease, Rotavirus Enteritis, Scabies, Sinusitis, Strabismus ...
Pediatric Database - Reiter's Disease, Rotavirus Enteritis, ... pedbase - The Pediatric Database ... 1994 -2007 Pedbase.org. Powered by Database of Pediatrics ...
http://www.pedbase.org/r-s
www.pedbase.org
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Hunter syndrome - Wikipedia, the free encyclopedia
Hunter syndrome, or mucopolysaccharoidosis Type II, is a lysosomal storage ... 1:Hurler/Scheie ˇ 2:Hunter ˇ 3:Sanfilippo ABCD ˇ 4:Morquio ˇ 6:Maroteaux-Lamy ˇ 7:Sly ...
http://en.wikipedia.org/wiki/Hunter_syndrome
en.wikipedia.org
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Primary Ciliary Dyskinesia -- GeneReviews -- NCBI Bookshelf
( 2) Classic Kartagener syndrome with situs inversus, chronic sinusitis, and ... In: Scriver CR, Beaudet AL, Sly WS, Valle D, Vogelstein B (eds) The Metabolic ...
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=pcd
www.ncbi.nlm.nih.gov
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Rubinstein-Taybi Syndrome -- GeneReviews -- NCBI Bookshelf
All but Muenke syndrome and FGFR2-related isolated coronal synostosis are ... In: Scriver CR, Beaudet AL, Sly WS, Valle D, Vogelstein B (eds) The Metabolic ...
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=rsts
www.ncbi.nlm.nih.gov
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Treacher Collins Syndrome -- GeneReviews -- NCBI Bookshelf
Treacher Collins syndrome (TCS) is characterized by hypoplasia of the zygomatic ... In: Scriver CR, Beaudet AL, Sly WS, Valle D, Vogelstein B (eds) The Metabolic ...
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=tcs
www.ncbi.nlm.nih.gov
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MERCK MANUALS
Clinical features: Similar to Hurler's syndrome but milder and no corneal ... MPS VII (Sly's. syndrome; 253220) ?-Glucuronidase. GUSB (7q21.11)* Onset: 1?4 yr ...
http://www.merck.com/media/mmpe/pdf/Table_296-4w.pdf
www.merck.com
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Werner Syndrome -- GeneReviews -- NCBI Bookshelf
Werner syndrome is inherited in an autosomal recessive manner. ... In: Scriver CR, Beaudet AL, Sly WS, Valle D, Vogelstein B (eds) The Metabolic ...
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=werner
www.ncbi.nlm.nih.gov
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Genomics|HuGENet|Fact sheets|MCAD Deficiency Medium-chain acyl-CoA ...
Chap 45 in: Scriver C, Beaudet A, Sly W, Valle D, editors. ... between the G985A MCAD allelic variant and sudden infant death syndrome (SIDS) ...
http://www.cdc.gov/genomics/hugenet/factsheets/FS_MCAD.htm
www.cdc.gov
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Birt-Hogg-Dubé Syndrome
The clinical characteristics of Birt-Hogg-Dubé syndrome (BHDS) ... Individuals with VHL syndrome are also at ... In: Scriver CR, Beaudet AL, Sly WS, Valle D, ...
http://www.ncbi.nlm.nih.gov/bookshelf/picrender.fcgi?book=ge...
www.ncbi.nlm.nih.gov
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Carbonic anhydrase II deficiency syndrome: recessive osteopetrosis with ...
... WA, Paul A, Sly WS. ... This autosomal recessive syndrome includes osteopetrosis with ... Syndrome. Tooth Abnormalities/complications. Substances: ...
http://www.ncbi.nlm.nih.gov/pubmed/3081869
www.ncbi.nlm.nih.gov
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Coarse facial features - Wikipedia, the free encyclopedia
Mucopolysaccharidosis type 2 Hunter syndrome- mild form, ... Mucopolysaccharidosis type 7 Sly syndrome, Mucopolysaccharidosis type I Hurler syndrome, ...
http://en.wikipedia.org/wiki/Coarse_facial_features
en.wikipedia.org
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Bloom's Syndrome -- GeneReviews -- NCBI Bookshelf
Bloom's syndrome is inherited in an autosomal recessive manner. ... In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The Metabolic and Molecular ...
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=bloom
www.ncbi.nlm.nih.gov
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Brugada Syndrome -- GeneReviews -- NCBI Bookshelf
Figure 1. Characteristic ECG in Brugada syndrome. ( more... In: Scriver CR, Beaudet AL, Sly WS, Valle D, Vogelstein B (eds) The Metabolic ...
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=brugada
www.ncbi.nlm.nih.gov
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Beta-glucuronidase - Wikipedia, the free encyclopedia
3 Sly Syndrome. 4 Molecular Applications: Use as a Reporter Gene. 5 References. 6 External links ... disease known as Sly syndrome or Mucopolysaccharidosis VII. ...
http://en.wikipedia.org/wiki/Glucuronidase
en.wikipedia.org
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Ehlers-Danlos Syndrome, Hypermobility Type -- GeneReviews -- NCBI Bookshelf
Most individuals diagnosed with the syndrome have an affected parent. ... In: Scriver CR, Beaudet AL, Sly WS, Valle D, Vogelstein B (eds) The Metabolic ...
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=eds3
www.ncbi.nlm.nih.gov
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Lowe Syndrome -- GeneReviews -- NCBI Bookshelf
Fanconi syndrome is usually not clinically ... Males with Lowe syndrome. ... In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The Metabolic and Molecular ...
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=lowe
www.ncbi.nlm.nih.gov
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List of incurable diseases - Wikipedia, the free encyclopedia
Scheie syndrome. Schindler disease. Schizophrenia. Sialidosis (mucolipidosis I) Sly syndrome. Spherocytosis. Spinocerebellar ataxia. Spreading adenocarcinoma ...
http://en.wikipedia.org/wiki/List_of_incurable_diseases
en.wikipedia.org
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Kallmann Syndrome
Kallmann syndrome (KS) is characterized by ... mutations in FGFR1 is Pfeiffer syndrome type 1. However, of the ... CR, Beaudet AL, Sly WS, Valle D, ...
http://www.ncbi.nlm.nih.gov/bookshelf/picrender.fcgi?book=ge...
www.ncbi.nlm.nih.gov
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Bloom's Syndrome
Bloom's syndrome is characterized by severe prenatal and postnatal ... In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The Metabolic ...
http://www.ncbi.nlm.nih.gov/bookshelf/picrender.fcgi?book=ge...
www.ncbi.nlm.nih.gov
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Chromosome 7 (human) - Wikipedia, the free encyclopedia
Ehlers-Danlos syndrome, classical type. hemochromatosis ... mucopolysaccharidosis type VII or Sly syndrome. myelodysplastic syndrome. nonsyndromic deafness ...
http://en.wikipedia.org/wiki/Chromosome_7_(human)
en.wikipedia.org
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List of diseases (S) - Wikipedia, the free encyclopedia
Sackey Sakati Aur syndrome. Sacral agenesis. Sacral defect anterior sacral ... Sly syndrome. Small cell lung cancer. Small non-cleaved cell lymphoma. Smallpox ...
http://en.wikipedia.org/wiki/List_of_diseases_(S)
en.wikipedia.org
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Lysosomal storage disease - Wikipedia, the free encyclopedia
... (including Hunter syndrome and Hurler disease) ... MPS VII Sly Syndrome. Mucolipidosis I/Sialidosis. Mucolipidosis IIIC. Mucolipidosis type IV ...
http://en.wikipedia.org/wiki/Lysosomal_storage_disease
en.wikipedia.org
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Cohen Syndrome -- GeneReviews -- NCBI Bookshelf
Cohen syndrome is inherited in an autosomal recessive manner. ... In: Scriver CR, Beaudet AL, Sly WS, Valle D, Vogelstein B (eds) The Metabolic ...
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=cohen
www.ncbi.nlm.nih.gov
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Pectus carinatum - Wikipedia, the free encyclopedia
... Osteogenesis imperfecta, multiple lentigines syndrome, and Sly syndrome. ... Omphalocele ˇ Gastroschisis ˇ Prune belly syndrome. see also non-congenital, ...
http://en.wikipedia.org/wiki/Pectus_carinatum
en.wikipedia.org
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