blister(s) or bump(s) on leg(s), itching leg(s), skin nodule(s)

Dermatofibromas are harmless benign skin growths, found especially on the legs, that range in size from about 0.5 to 1 cm. They are hard papules (rounded bumps) that may appear in a variety of colors, usually brownish to tan. Typical dermatofibromas cause little or no discomfort, although itching and tenderness can occur. Some physicians and researchers believe dermatofibromas form as a reaction to previous injuries such as insect bites or thorn pricks. They are composed of disordered collagen laid down by fibroblasts. Rarely, basal cell carcinoma may develop in a dermatofibroma. ... 

bruises on leg(s), cough, poor appetite, weakness

Metastasis (Greek: change of the state), sometimes abbreviated Mets, is the spread of cancer from its primary site to other places in the body (e.g., brain, liver). ... 

lump or swelling in groin in males, lump(s) in skin, pain in several joints, swollen joint(s)

The hyper-IgM syndrome is actually a family of genetic immunodeficiencies, as compared to the Acquired Immunodeficiency Syndrome (AIDS). In all types, the level of immunoglobulin M (IgM) is elevated or relatively normal. Some hyper-IgM syndromes are actually deficiencies of the other immunoglobulin classes IgA, IgG, and IgE. IgM is the constitutively expressed form of antibody that all B cells produce prior to class-switching after exposure to recognized antigen. Total neutrophil count is also typically low. Treatment includes IV-Ig infusion. Five types have been characterized: ... 

lump(s) in skin, pus draining from skin, rash, scaly patches on skin

is a heterogeneous group of disorders characterized by recurrent staphylococcal infections, unusual eczema-like skin rashes, severe lung infections that result in pneumatoceles (balloon-like lesions that may be filled with air or pus or scar tissue) and very high concentrations of serum IgE. Some patients have an autosomal dominant form of the disease; these patients have problems with their bones including recurrent fractures and scoliosis. Many patients with autosomal dominant hyper IgE syndrome fail to lose their baby teeth and have two sets of teeth simultaneously. ... 

blister(s) or bump(s) on skin, cough, difficulty walking, pain in foot (feet)

Mycetoma, or Madura Foot, is an important disease in arid and semi-arid regions around the globe. It is found in Brazil, Mexico, the Sahel, in pan-Arabia, and in semi-arid areas of India. It is found as far north as Romania. ... 

blister(s) or bump(s) on skin, lump or swelling on leg(s), rash, skin nodule(s)

Pinta is a human skin disease endemic to Mexico, Central America, and South America. It is caused by infection with a spirochete, Treponema carateum, which is morphologically and serologically indistinguishable from the organism that causes syphilis. ... 

blister(s) or bump(s) on finger(s), muscle weakness in arm(s), muscle weakness in leg(s), weakness

Dermatomyositis is connective-tissue disease that is characterized by inflammation of the muscles and the skin. Its cause is unknown, but it may result from either a viral infection or an autoimmune reaction. Up to 50% of the cases may be a paraneoplastic phenomenon, indicating the presence of cancer. ... 

bruises on foot (feet), lumps or swelling in multiple areas, rash, skin nodule(s)

Wiskott-Aldrich syndrome (WAS) is a rare X-linked recessive disease characterized by eczema, thrombocytopenia (low platelet counts), immune deficiency, and bloody diarrhea (due to the low platelet counts). It is also sometimes called the eczema-thrombocytopenia-immunodeficiency syndrome in keeping with Aldrich's original description in 1954. ...